Different effects of visual deprivation on vasoactive intestinal polypeptide (VIP)-containing cells in the retinas of juvenile and adult rats.

Herbst H, Thier P

Experimental brain research1 Oct 1996Cited by 9 (Europe PMC)

PMID8911929DOI10.1007/bf00228724PepBankPUB-08911929

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01AnimalEndogenous levelAnimal study (in vivo)Other
In adult rats, visual deprivation suppressed retinal VIP-like immunoreactivity and reduced VIP+ cells to about 30% of control after about 50 days.
In plain wordsIn adult rats, keeping the eyes without visual input lowered the retina's own VIP strongly over about 50 days.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseVIP-like immunoreactivity after visual deprivation, adult rats
Study
ratn: not reported in source
Retinal immunohistochemistry after visual deprivation
Comparator
Control
Outcome group
Endogenous peptide levels · Eye
Measurements
VIP+ cell number
≈ 30 % of control
adult rats, about 50 days of deprivation
Source sentences
Summary
In adult rats visual deprivation caused a marked suppression of VIP-like immunoreactivity (IR) in both somata and processes of VIP+ cells which increased linearly over time, reducing the number of VIP+ cells to about 30% of the control value after approximately 50 days of deprivation.
1 context sentence(design, population, supporting numbers)
Summary · context
Reasoning that a careful analysis of the exact conditions of this interaction and its time course might offer clues to the functional role of retinal VIP, we performed a quantitative immunohistochemical analysis of the effects of visual deprivation on the retinal VIP+ system in adult and in visually…
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0891192901
02AnimalEndogenous levelAnimal study (in vivo)Other
In juvenile rats without previous visual experience, visual deprivation decreased VIP+ cells and fibers much less and much more slowly than in adult rats.
In plain wordsIn young rats, lack of visual input lowered the retina's own VIP much less and more slowly than in adult rats.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseVIP+ cells after visual deprivation, juvenile rats
Study
ratn: not reported in source
Retinal immunohistochemistry after visual deprivation
Outcome group
Endogenous peptide levels · Eye
Source sentences
Summary
However, the effects of visual deprivation were dependent on the developmental state of the rats, since juvenile rats without previous visual experience exhibited a decrease in VIP+ cells and fibers which was much smaller and occurred significantly slower than in adult rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Reasoning that a careful analysis of the exact conditions of this interaction and its time course might offer clues to the functional role of retinal VIP, we performed a quantitative immunohistochemical analysis of the effects of visual deprivation on the retinal VIP+ system in adult and in visually…
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0891192902
03AnimalEndogenous levelAnimal study (in vivo)Other
In juvenile and adult rats, the suppression of retinal VIP-like immunoreactivity was completely reversible after return to a normal visual environment.
In plain wordsIn young and adult rats, the retina's own VIP returned fully when the rats went back to normal visual surroundings.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseReversibility of VIP suppression
Study
ratn: not reported in source
Retinal immunohistochemistry after visual deprivation
Outcome group
Endogenous peptide levels · Eye
Source sentences
Summary
The suppression of VIP-like IR was completely reversible in both juvenile and adult rats when previously deprived rats were returned to a normal visual environment.
1 context sentence(design, population, supporting numbers)
Summary · context
Reasoning that a careful analysis of the exact conditions of this interaction and its time course might offer clues to the functional role of retinal VIP, we performed a quantitative immunohistochemical analysis of the effects of visual deprivation on the retinal VIP+ system in adult and in visually…
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0891192903
04AnimalEndogenous levelAnimal study (in vivo)Other
In adult rats, the changes were specific for VIP and did not depend on monocular lid suture versus constant darkness.
In plain wordsIn rats, the drop in the retina's own VIP did not depend on closing one eye or keeping rats in the dark.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseSpecificity of VIP suppression and form of deprivation
Study
ratn: not reported in source
Retinal immunohistochemistry after visual deprivation
Outcome group
Endogenous peptide levels · Eye
Source sentences
Summary
The observed changes were specific for VIP and were independent of the form of deprivation used (monocular lid suture versus keeping rats in constant darkness).
1 context sentence(design, population, supporting numbers)
Summary · context
Reasoning that a careful analysis of the exact conditions of this interaction and its time course might offer clues to the functional role of retinal VIP, we performed a quantitative immunohistochemical analysis of the effects of visual deprivation on the retinal VIP+ system in adult and in visually…
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0891192904

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Version history

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Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

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