In conformational calculations, the oxytocin-selective antagonist penicilide probably mimics the Tyr2 residue and the Ile3 or Leu8 residues of oxytocin, which links to its affinity and selectivity.
In plain wordsIn computer models, a drug that blocks the oxytocin receptor probably copies parts of the oxytocin shape.
- Peptide
- Oxytocin
- Outcome
- Not applicableMimicry of oxytocin residues by a non-peptide antagonist
- Study
n: not reported in source
Conformational energy calculations- Outcome group
- Receptor activity and mechanism · Pharmacology
Source sentences
with mimicking the Tyr2 residue and the Ile3 or Leu8 residues of OT by the outer benzene ring and the isobutyl group of compound 1.
1 context sentence(design, population, supporting numbers)
The obtained low-energy conformations of compound 1 were compared with low-energy conformations of oxytocin (OT)
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.