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Study · Animal study (in vivo) · rat · 1996

4 results

Effects of two protein-free peptide derivatives on passive avoidance behaviour of 24-month-old rats.

Hutter-Paier B, Eggenreich U, Windisch M

Arzneimittel-Forschung1 Mar 1996Cited by 8 (Europe PMC)

PMID8901141 (opens in a new tab)PepBankPUB-08901141
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In old rats, Cerebrolysin improved passive avoidance extinction performance compared with saline controls.

    In plain wordsIn rats, Cerebrolysin improved passive avoidance extinction performance compared with saline controls.

    Peptide
    Cerebrolysin
    Outcome
    IncreasePassive avoidance extinction performance
    Study

    ratn: not reported in source

    24-month-old rats in passive avoidance task
    Comparator
    Saline
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    100 mg/kg b.wt. · subcutaneous injection · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    PAR-extinction testing showed that PAR latencies were treatment dependent (p < 0.001) due to the fact that PD and PD-exp treated animals displayed better performance.
    3 context sentences
    Summary · context
    The present study investigated the behavioural effects of this peptide derivative PD (100 mg/kg b.wt.), a related experimental peptide derivative PD-exp (1 mg/kg b.wt.) and a 0.9% saline control, on passive avoidance reaction (PAR) of 24-month-old male and female rats.
    Summary · context
    Rats were pre-treated chronically for 7 days.
    Summary · context
    Passive avoidance procedure started one day after the last subcutaneous injection with a single PAR-acquisition training session.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In old rats, Cerebrolysin improved other observed behavioural elements compared with saline controls; the abstract does not name them.

    In plain wordsIn rats, Cerebrolysin improved other observed behaviours compared with saline controls.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseOther observed behavioural elements
    Study

    ratn: not reported in source

    24-month-old rats in passive avoidance task
    Comparator
    Saline
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    100 mg/kg b.wt. · subcutaneous injection · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    The same was true for all other behavioural elements observed.
    4 context sentences
    Summary · context
    PAR-extinction testing showed that PAR latencies were treatment dependent (p < 0.001) due to the fact that PD and PD-exp treated animals displayed better performance.
    Summary · context
    The present study investigated the behavioural effects of this peptide derivative PD (100 mg/kg b.wt.), a related experimental peptide derivative PD-exp (1 mg/kg b.wt.) and a 0.9% saline control, on passive avoidance reaction (PAR) of 24-month-old male and female rats.
    Summary · context
    Rats were pre-treated chronically for 7 days.
    Summary · context
    Passive avoidance procedure started one day after the last subcutaneous injection with a single PAR-acquisition training session.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In old female rats, Cerebrolysin changed the capability to extinguish step-through behaviour compared with saline controls.

    In plain wordsIn female rats, Cerebrolysin changed step-through behaviour extinction compared with saline controls.

    Peptide
    Cerebrolysin
    Outcome
    Direction not reportedFemale step-through extinction
    Study

    ratn: not reported in source

    24-month-old rats in passive avoidance task
    Comparator
    Saline
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    100 mg/kg b.wt. · subcutaneous injection · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    In this study we were able to demonstrate that s.c. administration of PD and PD-exp changes the capability of old female but not of old male rats to extinguish step-through behaviour.
    3 context sentences
    Summary · context
    The present study investigated the behavioural effects of this peptide derivative PD (100 mg/kg b.wt.), a related experimental peptide derivative PD-exp (1 mg/kg b.wt.) and a 0.9% saline control, on passive avoidance reaction (PAR) of 24-month-old male and female rats.
    Summary · context
    Rats were pre-treated chronically for 7 days.
    Summary · context
    Passive avoidance procedure started one day after the last subcutaneous injection with a single PAR-acquisition training session.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In old male rats, Cerebrolysin did not change the capability to extinguish step-through behaviour compared with saline controls.

    In plain wordsIn male rats, Cerebrolysin did not change step-through behaviour extinction compared with saline controls.

    Peptide
    Cerebrolysin
    Outcome
    No significant changeMale step-through extinction
    Study

    ratn: not reported in source

    24-month-old rats in passive avoidance task
    Comparator
    Saline
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    100 mg/kg b.wt. · subcutaneous injection · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    In this study we were able to demonstrate that s.c. administration of PD and PD-exp changes the capability of old female but not of old male rats to extinguish step-through behaviour.
    3 context sentences
    Summary · context
    The present study investigated the behavioural effects of this peptide derivative PD (100 mg/kg b.wt.), a related experimental peptide derivative PD-exp (1 mg/kg b.wt.) and a 0.9% saline control, on passive avoidance reaction (PAR) of 24-month-old male and female rats.
    Summary · context
    Rats were pre-treated chronically for 7 days.
    Summary · context
    Passive avoidance procedure started one day after the last subcutaneous injection with a single PAR-acquisition training session.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

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