Skip to content

Study · Animal study (in vivo) · rat · 1996

2 results

Effects of chronic renal failure on plasma clearance of insulin-like growth factor I, des-(1-3)IGF-I, and LR3IGF-I.

Gillespie CM, Hazel SJ, Walton PE, Martin AA

The American journal of physiology1 Oct 1996Cited by 3 (Europe PMC)

PMID8897852 (opens in a new tab)DOI10.1152/ajpendo.1996.271.4.e649 (opens in a new tab)PepBankPUB-08897852
Publisher pagePubMedAsk about this study
Jump to 2 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In rats with chronic renal failure, total plasma clearance of LR3IGF-I was significantly increased.

    In plain wordsIn rats with chronic renal failure, LR3IGF-I cleared from the plasma faster.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseLR3IGF-I total clearance in chronic renal failure
    Study

    ratn: not reported in source

    Rat model of chronic renal failure
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Total clearance of LR3IGF-I was significantly increased.
    1 context sentence
    Summary · context
    Using a rat model of chronic renal failure (CRF), we examined insulin-like growth factor I (IGF-I) clearance, degradation, organ distribution, and IGF binding profiles in plasma.
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    In rats with chronic renal failure, degradation of LR3IGF-I was increased, which was linked to reduced IGF binding in the 150-kDa complex.

    In plain wordsIn rats with chronic renal failure, LR3IGF-I broke down more, linked to less binding in the large IGF complex.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseLR3IGF-I degradation in chronic renal failure
    Study

    ratn: not reported in source

    Rat model of chronic renal failure
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Increased degradation of both IGF-I and LR3IGF-I was associated with reduced IGF binding in the 150-kDa complex.
    1 context sentence
    Summary · context
    Using a rat model of chronic renal failure (CRF), we examined insulin-like growth factor I (IGF-I) clearance, degradation, organ distribution, and IGF binding profiles in plasma.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 3 to 4Current

    21 Oct 2026, 13:52 UTC

    The same notice was added 2 times, first on 21 Oct 2026, 12:50 UTC. The status did not change between them.

    Study data updated · source update from Europe PMC

  2. Version 2

    13 Oct 2026, 21:44 UTC

    Study results updated

  3. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.