Intracerebroventricular administration of the growth hormone-releasing peptide KP-102 increases food intake in free-feeding rats.

Okada K, Ishii S, Minami S, Sugihara H, Shibasaki T, Wakabayashi I

Endocrinology1 Nov 1996Cited by 55 (Europe PMC)

PMID8895390DOI10.1210/endo.137.11.8895390PepBankPUB-08895390

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In free-feeding rats, intracerebroventricular KP-102 at picomole doses stimulated food intake.
In plain wordsIn rats, a tiny dose of KP-102 injected into the brain made the animals eat more.
Peptide
GHRP-2
Outcome
IncreaseFood intake after ICV KP-102
Study
ratn: not reported in source
Free-feeding rats
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
picomole doses · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Intracerebroventricular (ICV) administration of picomole doses of a newly developed GHRP, KP-102, or human GHRH stimulated feeding
1 context sentence(design, population, supporting numbers)
Summary · context
The present studies were conducted to test the hypothesis that GHRPs may also potentiate the central effect of GHRH on feeding in free-feeding rats.
Report a problemFND-0889539001
02AnimalAnimal study (in vivo)Efficacy outcome
In free-feeding rats, the feeding increase seen with ICV KP-102 was not reproduced by systemic injection.
In plain wordsIn rats, KP-102 given by injection into the body did not raise food intake the way a brain injection did.
Peptide
GHRP-2
Outcome
No significant changeFood intake after systemic KP-102
Study
ratn: not reported in source
Free-feeding rats
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · systemic injectionAs given in this study (rat).
Source sentences
Summary
but the phenomenon was not reproduced by systemic injection.
1 context sentence(design, population, supporting numbers)
Summary · context
The present studies were conducted to test the hypothesis that GHRPs may also potentiate the central effect of GHRH on feeding in free-feeding rats.
Report a problemFND-0889539002
03AnimalAnimal study (in vivo)Mechanism
In free-feeding rats, prior ICV injection of a GHRH antagonist did not influence the increase in food intake induced by KP-102.
In plain wordsIn rats, blocking the GHRH receptor in the brain did not stop the extra eating caused by KP-102.
Peptide
GHRP-2
Outcome
No significant changeEffect of GHRH antagonist pretreatment on KP-102-induced food intake
Study
ratn: not reported in source
Free-feeding rats
Comparator
GHRH antagonist pretreatment
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
Dose not stated · intracerebroventricularAs given in this study (rat).
Source sentences
Summary
A prior ICV injection of a GHRH antagonist completely prevented the increase of food intake evoked by GHRH, but this pretreatment did not influence the increase in food intake induced by KP-102.
1 context sentence(design, population, supporting numbers)
Summary · context
The present studies were conducted to test the hypothesis that GHRPs may also potentiate the central effect of GHRH on feeding in free-feeding rats.
Report a problemFND-0889539003

Studies that did not test the peptide alone1

In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-2.

04AnimalNot a test of GHRP-2 aloneAnimal study (in vivo)Efficacy outcome
In free-feeding rats, ICV co-administration of maximally effective doses of GHRH and KP-102 increased food intake more than either peptide alone.
In plain wordsIn rats, GHRH and KP-102 together in the brain increased food intake more than either peptide alone.
Peptide
GHRP-2
Outcome
IncreaseFood intake after co-administration of GHRH and KP-102
Study
ratn: not reported in source
Free-feeding rats
Comparator
Maximum dose of either peptide alone
Outcome group
Appetite and food intake · Metabolic and weight
Source sentences
Summary
When maximally effective doses of GHRH and KP-102 were co-administered ICV, the amount of food intake increased significantly compared with after ICV injection of a maximum dose of either peptide alone.
1 context sentence(design, population, supporting numbers)
Summary · context
The present studies were conducted to test the hypothesis that GHRPs may also potentiate the central effect of GHRH on feeding in free-feeding rats.
In this study, GHRP-2 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-2.
Report a problemFND-0889539004

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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