In binding assays, des(1‑3)-IGF-I did not facilitate IGFBP-2 binding to human fibroblast extracellular matrix.
In plain wordsIn lab tests, des(1‑3)-IGF-I did not help IGFBP-2 bind to human fibroblast extracellular matrix.
- Peptide
- IGF-1 DES (des(1-3)IGF-I)
- Outcome
- No significant changeFacilitation of IGFBP-2 binding to extracellular matrix
- Study
n: not reported in source
IGFBP-2 binding assays- Outcome group
- Receptor activity and mechanism · Pharmacology
- Studied dose
- Dose not stated
Source sentences
IGF-II was more potent than IGF-I in facilitating the binding interaction, and des(1-3)-IGF-I or insulin had no effect, suggesting that IGF binding to IGFBP-2 is required for this effect to be detected.
1 context sentence(design, population, supporting numbers)
Binding appeared to be physiologically significant, as IGFBP-2 bound to human fibroblast ECM if IGF-I or IGF-II was added.