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Study · In vitro (cell-free) · rat · 1996

1 result

Characterization of an insulin-like growth factor binding protein-5 protease produced by rat articular chondrocytes and a neuroblastoma cell line.

Matsumoto T, Gargosky SE, Kelley K, Rosenfeld RG

Growth regulation1 Sept 1996Cited by 9 (Europe PMC)

PMID8894652 (opens in a new tab)PepBankPUB-08894652
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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cell-free)Mechanism

    In cell-free conditioned medium, des(1‑3)IGF-I inhibited IGFBP-5 proteolysis less effectively than IGF-I and IGF-II.

    In plain wordsIn lab tests, des(1‑3)IGF-I inhibited IGFBP-5 breakdown less effectively than IGF-I and IGF-II.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    DecreaseIGFBP-5 proteolysis inhibition
    Study

    ratn: not reported in source

    Cell-free conditioned medium from articular chondrocytes and B104 cells
    Comparator
    IGF-I and IGF-II
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We also examined the effect of IGFs on IGFBP-5 protease activity, and found that IGF-I and -II inhibited the proteolysis in cell-free conditioned medium, while des(1-3) IGF-I was less effective.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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