In cultured rat sciatic nerve segments, long R3IGF-I at nM concentrations increased [3H]thymidine incorporation compared with control segments.
In plain wordsIn cultured rat nerve segments, long R3IGF-I increased DNA synthesis compared with control segments.
- Peptide
- IGF-1 LR3
- Outcome
- Increase[3H]thymidine incorporation in nerve segments
- Study
ratn: not reported in source
cultured sciatic nerve segments- Comparator
- Control segments
- Outcome group
- Cell proliferation and differentiation · Nervous system and cognition
- Studied dose
- 0.1-1.7 nMAs given in this study (rat).
Source sentences
Segments cultured in nM (0.1-1.7 nM) concentrations of insulin, truncated IGF-I (tIGF-I), long R3IGF-I, or IGF-II exhibited an increase in [3H]thymidine incorporation compared with control segments.
1 context sentence(design, population, supporting numbers)
In this study we investigated the effects of insulin, insulin-like growth factor I and II (IGF-I and IGF-II), IGF-I analogues, and factors that interfere with their respective receptors, on [3H]thymidine incorporation into cultured nerve segments from the rat sciatic nerve.