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Study · Animal study (in vivo) · cattle (holstein calves) · 1996

8 results

Characteristics of growth hormone secretion responsiveness to growth hormone-releasing peptide-2 (GHRP-2 or KP102) in calves.

Roh SG, Matsunaga N, Hidaka S, Hidari H

Endocrine journal1 Jun 1996Cited by 13 (Europe PMC)

PMID8886623 (opens in a new tab)DOI10.1507/endocrj.43.291 (opens in a new tab)PepBankPUB-08886623
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In calves, 14 days of chronic KP102 significantly increased average daily gain by 36.4% over the control.

    In plain wordsIn calves, 14 days of continuous KP102 raised daily weight gain compared with control calves.

    Peptide
    GHRP-2
    Outcome
    IncreaseAverage daily gain during chronic KP102
    Study

    cattle (Holstein calves)n = 8

    Comparator
    Control calves
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    12.5 micrograms/kgBW per hour · subcutaneous osmotic pump · 14 daysAs given in this study (cattle (Holstein calves)).

    Measurements

    Average daily gain increase
    36.4%
    versus control

    Source sentences

    Summary
    During the 14 day period, average daily gain was significantly increased (36.4%) over the control (P < 0.05).
    2 context sentences
    Summary · context
    Each of the 4 calves was given with 12.5 micrograms/kgBW per hour KP102 and the other 4 calves served as the control.
    Summary · context
    In the chronic administration, 8 calves were implanted subcutaneously with osmotic pumps (Alzet pump).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In calves, chronic KP102 did not significantly change food efficiency, which was numerically 29.4% higher than the control.

    In plain wordsIn calves, continuous KP102 did not significantly change food efficiency compared with control calves.

    Peptide
    GHRP-2
    Outcome
    No significant changeFood efficiency during chronic KP102
    Study

    cattle (Holstein calves)n = 8

    Comparator
    Control calves
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    12.5 micrograms/kgBW per hour · subcutaneous osmotic pump · 14 daysAs given in this study (cattle (Holstein calves)).

    Measurements

    Food efficiency difference
    29.4%
    versus control, not significant

    Source sentences

    Summary
    Food efficiency was not significant, but numerically higher (29.4%) than the control.
    2 context sentences
    Summary · context
    Each of the 4 calves was given with 12.5 micrograms/kgBW per hour KP102 and the other 4 calves served as the control.
    Summary · context
    In the chronic administration, 8 calves were implanted subcutaneously with osmotic pumps (Alzet pump).
  3. 03AnimalAnimal study (in vivo)Activity measurement

    In calves, chronic administration of KP102 did not increase plasma GH concentration.

    In plain wordsIn calves, continuous KP102 did not raise growth hormone levels in the blood compared with control calves.

    Peptide
    GHRP-2
    Outcome
    No significant changePlasma GH concentration during chronic KP102
    Study

    cattle (Holstein calves)n = 8

    Comparator
    Control calves
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    12.5 micrograms/kgBW per hour · subcutaneous osmotic pump · 14 daysAs given in this study (cattle (Holstein calves)).

    Source sentences

    Summary
    The plasma GH concentration was not increased by chronic administration of KP102
    2 context sentences
    Summary · context
    Each of the 4 calves was given with 12.5 micrograms/kgBW per hour KP102 and the other 4 calves served as the control.
    Summary · context
    In the chronic administration, 8 calves were implanted subcutaneously with osmotic pumps (Alzet pump).
  4. 04AnimalAnimal study (in vivo)Activity measurement

    In calves, IGF-I appeared to increase more with chronic KP102 than in the control; no statistic is given.

    In plain wordsIn calves, IGF-I seemed to rise more with continuous KP102 than in control calves, but the abstract gives no test.

    Peptide
    GHRP-2
    Outcome
    IncreaseIGF-I during chronic KP102
    Study

    cattle (Holstein calves)n = 8

    Comparator
    Control calves
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    12.5 micrograms/kgBW per hour · subcutaneous osmotic pump · 14 daysAs given in this study (cattle (Holstein calves)).

    Source sentences

    Summary
    IGF-I appeared to increase in KP102-treated calves more than the control.
    2 context sentences
    Summary · context
    Each of the 4 calves was given with 12.5 micrograms/kgBW per hour KP102 and the other 4 calves served as the control.
    Summary · context
    In the chronic administration, 8 calves were implanted subcutaneously with osmotic pumps (Alzet pump).
  5. 05AnimalAnimal study (in vivo)Activity measurement

    In male Holstein calves, i.v. KP102 at 6.25 micrograms/kg BW significantly increased the 60-min GH AUC versus saline.

    In plain wordsIn calves, a single KP102 injection at 6.25 micrograms/kg raised growth hormone release more than saline.

    Peptide
    GHRP-2
    Outcome
    IncreaseGH AUC (60 min) after 6.25 micrograms/kg KP102
    Study

    cattle (Holstein calves)n = 6

    Comparator
    Saline
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    6.25 micrograms/kg BW · intravenousAs given in this study (cattle (Holstein calves)).

    Measurements

    GH AUC (60 min)
    676.3 ng/ml.min
    6.25 micrograms/kgBW KP102
    GH AUC (60 min)
    78.6 ng/ml.min
    saline

    Source sentences

    Summary
    The GH AUC (area under curve, ng/ml.min, mean +/- SEM) for 60 min was significantly increased with 6.25 (676.3 +/- 125.6), 12.5 (1574.8 +/- 318.0) and 25.0 (1578.7 +/- 214.6) micrograms/kgBW of KP102 than with saline (78.6 +/- 36.1) (P < 0.01).
    2 context sentences
    Summary · context
    This study was conducted to determine the effects of acute and chronic administration of GH-releasing peptide-2 (D-Ala-D-beta Nal-Ala-Trp-D-Phe-Lys-NH2, GHRP-2 or KP102) on GH responsiveness in male Holstein calves.
    Summary · context
    In the dose response study of acute administration, six calves were injected iv with saline or 6.25, 12.5 and 25.0 micrograms/kg body weight (BW) of KP102.
  6. 06AnimalAnimal study (in vivo)Activity measurement

    In male Holstein calves, i.v. KP102 at 12.5 micrograms/kg BW significantly increased the 60-min GH AUC versus saline.

    In plain wordsIn calves, a single KP102 injection at 12.5 micrograms/kg raised growth hormone release more than saline.

    Peptide
    GHRP-2
    Outcome
    IncreaseGH AUC (60 min) after 12.5 micrograms/kg KP102
    Study

    cattle (Holstein calves)n = 6

    Comparator
    Saline
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    12.5 micrograms/kg BW · intravenousAs given in this study (cattle (Holstein calves)).

    Measurements

    GH AUC (60 min)
    1574.8 ng/ml.min
    12.5 micrograms/kgBW KP102
    GH AUC (60 min)
    78.6 ng/ml.min
    saline

    Source sentences

    Summary
    The GH AUC (area under curve, ng/ml.min, mean +/- SEM) for 60 min was significantly increased with 6.25 (676.3 +/- 125.6), 12.5 (1574.8 +/- 318.0) and 25.0 (1578.7 +/- 214.6) micrograms/kgBW of KP102 than with saline (78.6 +/- 36.1) (P < 0.01).
    2 context sentences
    Summary · context
    This study was conducted to determine the effects of acute and chronic administration of GH-releasing peptide-2 (D-Ala-D-beta Nal-Ala-Trp-D-Phe-Lys-NH2, GHRP-2 or KP102) on GH responsiveness in male Holstein calves.
    Summary · context
    In the dose response study of acute administration, six calves were injected iv with saline or 6.25, 12.5 and 25.0 micrograms/kg body weight (BW) of KP102.
  7. 07AnimalAnimal study (in vivo)Activity measurement

    In male Holstein calves, i.v. KP102 at 25.0 micrograms/kg BW significantly increased the 60-min GH AUC versus saline.

    In plain wordsIn calves, a single KP102 injection at 25.0 micrograms/kg raised growth hormone release more than saline.

    Peptide
    GHRP-2
    Outcome
    IncreaseGH AUC (60 min) after 25.0 micrograms/kg KP102
    Study

    cattle (Holstein calves)n = 6

    Comparator
    Saline
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    25.0 micrograms/kg BW · intravenousAs given in this study (cattle (Holstein calves)).

    Measurements

    GH AUC (60 min)
    1578.7 ng/ml.min
    25.0 micrograms/kgBW KP102
    GH AUC (60 min)
    78.6 ng/ml.min
    saline

    Source sentences

    Summary
    The GH AUC (area under curve, ng/ml.min, mean +/- SEM) for 60 min was significantly increased with 6.25 (676.3 +/- 125.6), 12.5 (1574.8 +/- 318.0) and 25.0 (1578.7 +/- 214.6) micrograms/kgBW of KP102 than with saline (78.6 +/- 36.1) (P < 0.01).
    2 context sentences
    Summary · context
    This study was conducted to determine the effects of acute and chronic administration of GH-releasing peptide-2 (D-Ala-D-beta Nal-Ala-Trp-D-Phe-Lys-NH2, GHRP-2 or KP102) on GH responsiveness in male Holstein calves.
    Summary · context
    In the dose response study of acute administration, six calves were injected iv with saline or 6.25, 12.5 and 25.0 micrograms/kg body weight (BW) of KP102.
  8. 08AnimalAnimal study (in vivo)Activity measurement

    In calves, the GH response fell with repeated KP102 injections every 2 h, with the first and second responses higher than the third and fourth.

    In plain wordsIn calves, growth hormone responses to KP102 got smaller with repeated injections every 2 hours.

    Peptide
    GHRP-2
    Outcome
    DecreaseGH response to repeated KP102 injections
    Study

    cattle (Holstein calves)n: not reported in source

    Comparator
    First injection
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    12.5 micrograms/kgBW every 2 h · 8 hAs given in this study (cattle (Holstein calves)).

    Measurements

    GH AUC (60 min), first injection
    1162.9 ng/ml.min
    12.5 micrograms/kgBW KP102
    GH AUC (60 min), second injection
    604.7 ng/ml.min
    12.5 micrograms/kgBW KP102
    GH AUC (60 min), third injection
    304.4 ng/ml.min
    12.5 micrograms/kgBW KP102
    GH AUC (60 min), fourth injection
    320.7 ng/ml.min
    12.5 micrograms/kgBW KP102

    Source sentences

    Summary
    GH responses were decreased by multiple injections of 12.5 micrograms/kgBW KP102 at every 2 h for 8 h. The GH AUC for 60 min was decreased from the first injection (1162.9 +/- 313.3) to the second injection (604.7 +/- 131.9), but the response was significantly higher for the first and second injecti…

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

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