Potentiation of GABAA receptor in cultured mouse hippocampal cells by brain-derived peptide mixture cerebrolysin.

Zemková H, Krůĕk J, Vyskocil F

Physiological research1 Jan 1995Cited by 3 (Europe PMC)

PMID8869271PepBankPUB-08869271

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

3 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Mechanism
In newborn mouse hippocampal neurons held at -30 mV, Cerebrolysin induced inward currents of 0.2 to 1 nA in all neurons.
In plain wordsIn cells from newborn mouse brains, Cerebrolysin induced inward currents of 0.2 to 1 nA.
Peptide
Cerebrolysin
Outcome
IncreaseInward current
Study
mousen: not reported in source
Cultured hippocampal neurons from newborn mice
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
0.1 microgram per 1 ml · fast microperfusionAs given in this study (mouse).
Measurements
Inward current
0.2 to 1 nA
neurons held at -30 mV
Source sentences
Summary
Application of Cerebrolysin (0.1 microgram per 1 ml) by a fast microperfusion system induced an inward current of 0.2 to 1 nA in all neurones from newborn mouse hippocampi held at -30 mV membrane potential.
Report a problemFND-0886927101
02LabIn vitro (cells)Mechanism
In mouse hippocampal neurons, Cerebrolysin dialyzed through a 3.6 kD gut did not induce transmembrane current.
In plain wordsIn cells from mouse brains, dialyzed Cerebrolysin did not induce transmembrane current.
Peptide
Cerebrolysin
Outcome
Not applicableTransmembrane current after dialysis
Study
mousen: not reported in source
Cultured hippocampal neurons from newborn mice
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Cerebrolysin dialyzed through a 3.6 kD gut did not induce any transmembrane current but potentiated the response induced by GABA (10 microM) to 135%.
1 context sentence(design, population, supporting numbers)
Summary · context
Application of Cerebrolysin (0.1 microgram per 1 ml) by a fast microperfusion system induced an inward current of 0.2 to 1 nA in all neurones from newborn mouse hippocampi held at -30 mV membrane potential.
Report a problemFND-0886927105
03LabIn vitro (cells)Mechanism
In mouse hippocampal neurons, dialyzed Cerebrolysin potentiated the response induced by GABA to 135%.
In plain wordsIn cells from mouse brains, dialyzed Cerebrolysin increased the GABA-induced response to 135%.
Peptide
Cerebrolysin
Outcome
IncreaseGABA-induced response after dialysis
Study
mousen: not reported in source
Cultured hippocampal neurons from newborn mice
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Measurements
GABA-induced response
135%
dialyzed Cerebrolysin
Source sentences
Summary
Cerebrolysin dialyzed through a 3.6 kD gut did not induce any transmembrane current but potentiated the response induced by GABA (10 microM) to 135%.
1 context sentence(design, population, supporting numbers)
Summary · context
Application of Cerebrolysin (0.1 microgram per 1 ml) by a fast microperfusion system induced an inward current of 0.2 to 1 nA in all neurones from newborn mouse hippocampi held at -30 mV membrane potential.
Report a problemFND-0886927106

Studies that did not test the peptide alone3

In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Cerebrolysin.

04LabNot a test of Cerebrolysin aloneIn vitro (cells)Mechanism
In mouse hippocampal neurons, bicuculline reduced Cerebrolysin-induced currents by 65%.
In plain wordsIn cells from mouse brains, bicuculline reduced Cerebrolysin-induced currents by 65%.
Peptide
Cerebrolysin
Outcome
DecreaseBicuculline inhibition of Cerebrolysin-induced current
Study
mousen: not reported in source
Cultured hippocampal neurons from newborn mice
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Measurements
Current reduction
65%
bicuculline
Source sentences
Summary
Cerebrolysin-induced currents were reduced by the GABAA antagonist bicuculline (2 microM) by 65%, by the NMDA antagonist aminophosphovaleric acid (APV, 10 microM) by 27% and by the non-NMDA antagonist cyanonitriquinoxalinedione (CNQX, 10 microM) by 20%.
1 context sentence(design, population, supporting numbers)
Summary · context
Application of Cerebrolysin (0.1 microgram per 1 ml) by a fast microperfusion system induced an inward current of 0.2 to 1 nA in all neurones from newborn mouse hippocampi held at -30 mV membrane potential.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-0886927102
05LabNot a test of Cerebrolysin aloneIn vitro (cells)Mechanism
In mouse hippocampal neurons, APV reduced Cerebrolysin-induced currents by 27%.
In plain wordsIn cells from mouse brains, APV reduced Cerebrolysin-induced currents by 27%.
Peptide
Cerebrolysin
Outcome
DecreaseAPV inhibition of Cerebrolysin-induced current
Study
mousen: not reported in source
Cultured hippocampal neurons from newborn mice
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Measurements
Current reduction
27%
APV
Source sentences
Summary
Cerebrolysin-induced currents were reduced by the GABAA antagonist bicuculline (2 microM) by 65%, by the NMDA antagonist aminophosphovaleric acid (APV, 10 microM) by 27% and by the non-NMDA antagonist cyanonitriquinoxalinedione (CNQX, 10 microM) by 20%.
1 context sentence(design, population, supporting numbers)
Summary · context
Application of Cerebrolysin (0.1 microgram per 1 ml) by a fast microperfusion system induced an inward current of 0.2 to 1 nA in all neurones from newborn mouse hippocampi held at -30 mV membrane potential.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-0886927103
06LabNot a test of Cerebrolysin aloneIn vitro (cells)Mechanism
In mouse hippocampal neurons, CNQX reduced Cerebrolysin-induced currents by 20%.
In plain wordsIn cells from mouse brains, CNQX reduced Cerebrolysin-induced currents by 20%.
Peptide
Cerebrolysin
Outcome
DecreaseCNQX inhibition of Cerebrolysin-induced current
Study
mousen: not reported in source
Cultured hippocampal neurons from newborn mice
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Measurements
Current reduction
20%
CNQX
Source sentences
Summary
Cerebrolysin-induced currents were reduced by the GABAA antagonist bicuculline (2 microM) by 65%, by the NMDA antagonist aminophosphovaleric acid (APV, 10 microM) by 27% and by the non-NMDA antagonist cyanonitriquinoxalinedione (CNQX, 10 microM) by 20%.
1 context sentence(design, population, supporting numbers)
Summary · context
Application of Cerebrolysin (0.1 microgram per 1 ml) by a fast microperfusion system induced an inward current of 0.2 to 1 nA in all neurones from newborn mouse hippocampi held at -30 mV membrane potential.
In this study, Cerebrolysin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cerebrolysin.
Report a problemFND-0886927104

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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