GHRP6-stimulated hormone secretion in somatotrophs: involvement of intracellular and extracellular calcium sources.

Bresson-Bepoldin L, Dufy-Barbe L

Journal of neuroendocrinology1 Apr 1996Cited by 16 (Europe PMC)

PMID8861287DOI10.1046/j.1365-2826.1996.04608.xPepBankPUB-08861287

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

01LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism
In somatotrophs, thapsigargin inhibition of intracellular calcium mobilization reduced the hormone response to GHRP6.
In plain wordsIn cells, thapsigargin reduced the hormone response to GHRP6.
Peptide
GHRP-6
Outcome
DecreaseGH response with thapsigargin
Study
n: not reported in source
somatotrophs
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
We found that inhibition by thapsigargin of the intracellular Ca2+ mobilization phase significantly inhibited the hormone response to the peptide during 30 min incubations.
1 context sentence(design, population, supporting numbers)
Summary · context
In these experiments, we investigated the specific role of each of these two phases in the hormone response to GHRP6.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0886128701
02LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism
In somatotrophs, nifedipine reduced the secretory response to GHRP6 by 53 percent.
In plain wordsIn cells, nifedipine reduced the secretory response to GHRP6 by 53 percent.
Peptide
GHRP-6
Outcome
DecreaseGH response with nifedipine
Study
n: not reported in source
somatotrophs
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Measurements
Secretory response reduction
53 percent
nifedipine
Source sentences
Summary
Inhibition of the extracellular Ca2+ influx phase by nifedipine, a blocker of voltage-sensitive Ca2+ channels, resulted in a 53 percent reduction of the secretory response to 10(-5)M GHRP6.
1 context sentence(design, population, supporting numbers)
Summary · context
In these experiments, we investigated the specific role of each of these two phases in the hormone response to GHRP6.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0886128702
03LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism
In somatotrophs, phloretin antagonism of PKC completely inhibited the response to GHRP6.
In plain wordsIn cells, phloretin completely inhibited the response to GHRP6.
Peptide
GHRP-6
Outcome
DecreaseGH response with PKC antagonism
Study
n: not reported in source
somatotrophs
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
Antagonism of PKC by phloretin, a flavonoid which prevents PKC activation, and PKC depletion induced by a 24 h treatment with 10(-6)M PMA, completely inhibited the response to GHRP6.
1 context sentence(design, population, supporting numbers)
Summary · context
In these experiments, we investigated the specific role of each of these two phases in the hormone response to GHRP6.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0886128703
04LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism
In somatotrophs, PMA-induced PKC depletion completely inhibited the response to GHRP6.
In plain wordsIn cells, PKC depletion completely inhibited the response to GHRP6.
Peptide
GHRP-6
Outcome
DecreaseGH response with PKC depletion
Study
n: not reported in source
somatotrophs
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
Antagonism of PKC by phloretin, a flavonoid which prevents PKC activation, and PKC depletion induced by a 24 h treatment with 10(-6)M PMA, completely inhibited the response to GHRP6.
1 context sentence(design, population, supporting numbers)
Summary · context
In these experiments, we investigated the specific role of each of these two phases in the hormone response to GHRP6.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0886128704
05LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism
In somatotrophs, somatostatin suppressed the secretory response to GHRP6.
In plain wordsIn cells, somatostatin suppressed the secretory response to GHRP6.
Peptide
GHRP-6
Outcome
DecreaseGH response with somatostatin
Study
n: not reported in source
somatotrophs
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
Somatostatin, which also inhibits the second phase of the Ca2+ response, suppressed the secretory response to GHRP6.
1 context sentence(design, population, supporting numbers)
Summary · context
In these experiments, we investigated the specific role of each of these two phases in the hormone response to GHRP6.
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0886128705

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

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