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Study · Not a test of the peptide alone · 1996

3 results

Modulation of insulin-like growth factor (IGF) action by IGF-binding proteins in normal, benign, and malignant smooth muscle tissues.

van der Ven LT, Van Buul-Offers SC, Gloudemans T, Bloemen RJ, Roholl PJ, Sussenbach JS, Den Otter W

The Journal of clinical endocrinology and metabolism1 Oct 1996Cited by 11 (Europe PMC)

PMID8855813 (opens in a new tab)DOI10.1210/jcem.81.10.8855813 (opens in a new tab)PepBankPUB-08855813
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

  1. 01LabNot a test of IGF-1 LR3 aloneIn vitro (cells)Mechanism

    In cultured smooth muscle cells, comparison of IGF-I with the analogs long-R3IGF-I and des(1-3)-IGF-I showed a facilitating effect of IGFBPs on the growth-stimulating activity of a high concentration of IGF-I in cell lines with high IGFBP-3.

    In plain wordsIn cultured muscle cells, IGF-binding proteins helped a high dose of IGF-I stimulate growth when cells made a lot of IGFBP-3.

    Peptide
    IGF-1 LR3
    Outcome
    Not applicableFacilitating effect of IGFBPs on IGF-I growth stimulation
    Study

    humann: not reported in source

    cultured smooth muscle cells from myometrium and leiomyoma
    Outcome group
    Receptor activity and mechanism · Cancer

    Source sentences

    Summary
    Incubation of SMC cultures with IGF-I and the IGF-I analogs long-R3IGF-I and des(1-3)-IGF-I, which have decreased affinity for IGFBPs, revealed a facilitating effect of IGFBPs on the growth-stimulating activity of a high concentration of IGF-I in cell lines with high IGFBP-3 levels.
    1 context sentence
    Summary · context
    Here we investigate a possible modulating role of the binding proteins for the IGFs (IGFBPs) on the actions of IGFs.

    In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.

  2. 02LabNot a test of IGF-1 LR3 aloneIn vitro (cells)Mechanism

    In cultured smooth muscle cells, a lower IGFBP-3 level and a low concentration of added growth factors were a disadvantage for the facilitating effect.

    In plain wordsIn cultured muscle cells, less IGFBP-3 or a low dose of growth factor weakened the helping effect of binding proteins.

    Peptide
    IGF-1 LR3
    Outcome
    Not applicableConditions that reduce the IGFBP facilitating effect
    Study

    humann: not reported in source

    cultured smooth muscle cells from myometrium and leiomyoma
    Outcome group
    Receptor activity and mechanism · Cancer

    Source sentences

    Summary
    Both a decreased level of IGFBP-3 and a low concentration of the growth factors added were a disadvantage for the facilitating effect.
    1 context sentence
    Summary · context
    Here we investigate a possible modulating role of the binding proteins for the IGFs (IGFBPs) on the actions of IGFs.

    In this study, IGF-1 LR3 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 LR3.

  3. 03LabNot a test of IGF-1 DES (des(1-3)IGF-I) aloneIn vitro (cells)Mechanism

    In smooth muscle cell cultures, experiments with IGF-I and analogs including des(1‑3)-IGF-I revealed IGFBP facilitation of high-concentration IGF-I growth activity.

    In plain wordsIn cells with high IGFBP-3 levels, tests with IGF-I and its analogs showed that IGFBPs enhanced high-concentration IGF-I growth activity.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseIGFBP facilitation of IGF-I growth activity
    Study

    n: not reported in source

    Smooth muscle cell cultures with high IGFBP-3 levels
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health

    Source sentences

    Summary
    Incubation of SMC cultures with IGF-I and the IGF-I analogs long-R3IGF-I and des(1-3)-IGF-I, which have decreased affinity for IGFBPs, revealed a facilitating effect of IGFBPs on the growth-stimulating activity of a high concentration of IGF-I in cell lines with high IGFBP-3 levels.

    In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 3 to 4Current

    21 Oct 2026, 13:52 UTC

    The same notice was added 2 times, first on 21 Oct 2026, 12:50 UTC. The status did not change between them.

    Study data updated · source update from Europe PMC

  2. Version 2

    13 Oct 2026, 21:44 UTC

    Study results updated

  3. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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