Skip to content

Study · In vitro (cells) · 1996

2 results

Interrelationships between follicle stimulating hormone and the growth hormone--insulin-like growth factor--IGF-binding proteins axes in human granulosa cells in culture.

Barreca A, Artini PG, Cesarone A, Arvigo M, D'Ambrogio G, Genazzani AR, Giordano G, Minuto F

Journal of endocrinological investigation1 Jan 1996Cited by 15 (Europe PMC)

PMID8851690 (opens in a new tab)DOI10.1007/bf03347856 (opens in a new tab)PepBankPUB-08851690
Publisher pagePubMedAsk about this study
Jump to 2 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In cultured human granulosa cells, des(1‑3)IGF-I significantly stimulated E2 production, comparably to FSH in the tested dose range.

    In plain wordsIn cells, des(1‑3)IGF-I increased E2 production, comparably to FSH at the tested doses.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseE2 production
    Study

    humann: not reported in source

    Human luteinizing granulosa cells
    Comparator
    FSH in the tested dose range
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both IGF-I and des(1-3)IGF-I significantly (p < 0.001) stimulate E2 production by human GC in culture in a manner comparable to that of FSH in the dose range used.

Studies that did not test the peptide alone1

In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking IGF-1 DES (des(1-3)IGF-I).

  1. 02LabNot a test of IGF-1 DES (des(1-3)IGF-I) aloneIn vitro (cells)Mechanism

    In human granulosa cells, IGFBP-3 preincubation did not reduce the stimulatory effect of des(1‑3)IGF-I.

    In plain wordsIn cells, IGFBP-3 preincubation did not reduce the des(1‑3)IGF-I effect compared with no preincubation.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    No significant changeE2 response after IGFBP-3 preincubation
    Study

    humann: not reported in source

    Human luteinizing granulosa cells
    Comparator
    Without IGFBP-3 preincubation
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Preincubation for 2 h at 22 C with IGFBP-3, to allow the formation of the IGF-IGFBP complex, drastically reduced the stimulatory effect of IGF-I but not that of des(1-3)IGF-I.
    1 context sentence
    Summary · context
    Both IGF-I and des(1-3)IGF-I significantly (p < 0.001) stimulate E2 production by human GC in culture in a manner comparable to that of FSH in the dose range used.

    In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.