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Study · In vitro (cells) · 1996

3 results

Oxytocin receptors expressed and coupled to Ca2+ signalling in a human vascular smooth muscle cell line.

Yazawa H, Hirasawa A, Horie K, Saita Y, Iida E, Honda K, Tsujimoto G

British journal of pharmacology1 Mar 1996Cited by 27 (Europe PMC)

PMID8851493 (opens in a new tab)PMCIDPMC1909422 (opens in a new tab)DOI10.1111/j.1476-5381.1996.tb15263.x (opens in a new tab)PepBankPUB-08851493
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In a human vascular smooth muscle cell line, oxytocin competed for [3H]-AVP binding with the highest potency of the compounds tested.

    In plain wordsIn cells, oxytocin competed for vasopressin binding sites more strongly than the other compounds tested.

    Peptide
    Oxytocin
    Outcome
    Not applicableCompetition for [3H]-AVP binding
    Study

    humann: not reported in source

    human vascular smooth muscle cell line (HVSMC)
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Nonlabelled compounds compete for [3H]-AVP binding in the HVSMC membrane with an order of potency of oxytocin > lyspressin > or = AVP > Thr4, Gly7-oxytocin > (beta-mercapto-beta-beta-cyclopentamethylenepropionyl-O-Me Tyr2, Arg8) vasopressin > desmopressin > OPC21268 > OPC31260.
    1 context sentence
    Summary · context
    In a human vascular smooth muscle cell line (HVSMC), binding experiments with [3H]-arginine8-vasopressin (AVP) have shown the existence of a homogeneous population of binding sites with affinity (Kd value) of 0.65 nM and a maximum number of binding sites (Bmax) of 122 fmol mg-1 protein.
  2. 02LabIn vitro (cells)Mechanism

    In a human vascular smooth muscle cell line, oxytocin increased IP3 production, with greater efficacy than AVP.

    In plain wordsIn cells, oxytocin raised IP3 production more than vasopressin did.

    Peptide
    Oxytocin
    Outcome
    IncreaseIP3 production
    Study

    humann: not reported in source

    human vascular smooth muscle cell line (HVSMC)
    Comparator
    AVP
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In HVSMC both oxytocin and AVP increased inositol 1,4,5-trisphosphate (IP3) production and [Ca2+]i response, but the efficacy of the responses was greater for oxytocin than AVP.
    1 context sentence
    Summary · context
    In a human vascular smooth muscle cell line (HVSMC), binding experiments with [3H]-arginine8-vasopressin (AVP) have shown the existence of a homogeneous population of binding sites with affinity (Kd value) of 0.65 nM and a maximum number of binding sites (Bmax) of 122 fmol mg-1 protein.
  3. 03LabIn vitro (cells)Mechanism

    In a human vascular smooth muscle cell line, oxytocin increased the [Ca2+]i response, with greater efficacy than AVP.

    In plain wordsIn cells, oxytocin raised the intracellular calcium response more than vasopressin did.

    Peptide
    Oxytocin
    Outcome
    Increase[Ca2+]i response
    Study

    humann: not reported in source

    human vascular smooth muscle cell line (HVSMC)
    Comparator
    AVP
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In HVSMC both oxytocin and AVP increased inositol 1,4,5-trisphosphate (IP3) production and [Ca2+]i response, but the efficacy of the responses was greater for oxytocin than AVP.
    1 context sentence
    Summary · context
    In a human vascular smooth muscle cell line (HVSMC), binding experiments with [3H]-arginine8-vasopressin (AVP) have shown the existence of a homogeneous population of binding sites with affinity (Kd value) of 0.65 nM and a maximum number of binding sites (Bmax) of 122 fmol mg-1 protein.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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