The effect of vasoactive intestinal peptide (VIP) on mast cell invasion/degranulation in testicular interstitium of immobilized + cold stressed and beta-endorphin-treated rats.

Tunçel N, Gürer F, Aral E, Uzuner K, Aydin Y, Bayçu C

Peptides1 Jan 1996Cited by 23 (Europe PMC)

PMID8844772DOI10.1016/0196-9781(96)00083-6PepBankPUB-08844772

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In stressed rats, VIP inhibited the proliferation of mast cells in the testicular interstitium.
In plain wordsIn stressed rats, VIP reduced the growth in number of mast cells in the testis.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseMast cell proliferation in testicular interstitium
Study
ratn: not reported in source
Outcome group
Immune response · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
VIP inhibited proliferation and degranulation of mast cells
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of VIP on mast cell invasion/degranulation in testicular interstitium of stressed (immobilization and cold) and beta-endorphin-treated rats were investigated.
Summary · context
Because the most obvious effect of the stress on mast cell invasion/degranulation in testicular interstitium was observed in 45-day-old rats, the action of VIP in stressed and beta-endorphin-treated rats was only investigated at this age group.
Report a problemFND-0884477201
02AnimalAnimal study (in vivo)Efficacy outcome
In stressed rats, VIP inhibited the degranulation of mast cells in the testicular interstitium.
In plain wordsIn stressed rats, VIP reduced the release of granules from mast cells in the testis.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseMast cell degranulation in testicular interstitium
Study
ratn: not reported in source
Outcome group
Immune response · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
VIP inhibited proliferation and degranulation of mast cells
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of VIP on mast cell invasion/degranulation in testicular interstitium of stressed (immobilization and cold) and beta-endorphin-treated rats were investigated.
Summary · context
Because the most obvious effect of the stress on mast cell invasion/degranulation in testicular interstitium was observed in 45-day-old rats, the action of VIP in stressed and beta-endorphin-treated rats was only investigated at this age group.
Report a problemFND-0884477202
03AnimalAnimal study (in vivo)Efficacy outcome
In stressed rats, VIP increased the heparin content of mast cells in the testicular interstitium.
In plain wordsIn stressed rats, VIP raised the heparin content of testis mast cells.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseHeparin content of mast cells
Study
ratn: not reported in source
Outcome group
Immune response · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
increased heparin content of the cells
2 context sentences(design, population, supporting numbers)
Summary · context
The effect of VIP on mast cell invasion/degranulation in testicular interstitium of stressed (immobilization and cold) and beta-endorphin-treated rats were investigated.
Summary · context
Because the most obvious effect of the stress on mast cell invasion/degranulation in testicular interstitium was observed in 45-day-old rats, the action of VIP in stressed and beta-endorphin-treated rats was only investigated at this age group.
Report a problemFND-0884477203
04AnimalAnimal study (in vivo)Efficacy outcome
In stressed rats, VIP protected Leydig cells from stress-related damage.
In plain wordsIn stressed rats, VIP protected Leydig cells in the testis from stress damage.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseLeydig cell damage under stress
Study
ratn: not reported in source
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated
Source sentences
Summary
protected Leydig cells.
3 context sentences(design, population, supporting numbers)
Summary · context
In some areas of testicular interstitium of stressed rats, there were aplasic and/or inactive Leydig cells.
Summary · context
The effect of VIP on mast cell invasion/degranulation in testicular interstitium of stressed (immobilization and cold) and beta-endorphin-treated rats were investigated.
Summary · context
Because the most obvious effect of the stress on mast cell invasion/degranulation in testicular interstitium was observed in 45-day-old rats, the action of VIP in stressed and beta-endorphin-treated rats was only investigated at this age group.
Report a problemFND-0884477204

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

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