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Study · Animal study (in vivo) · guinea-pigs · 1996

5 results

Morphological features of bone healing under the effect of collagen-graft-glycosaminoglycan copolymer supplemented with the tripeptide Gly-His-Lys.

Pohunková H, Stehlík J, Váchal J, Cech O, Adam M

Biomaterials1 Aug 1996Cited by 19 (Europe PMC)

PMID8842360 (opens in a new tab)DOI10.1016/0142-9612(95)00310-x (opens in a new tab)PepBankPUB-08842360
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In guinea-pig bone defects, complete Colladel accelerated healing more than Colladel without GHK.

    In plain wordsIn guinea-pigs, complete Colladel accelerated bone healing more than Colladel without GHK.

    Peptide
    GHK (glycyl-L-histidyl-L-lysine)
    Outcome
    IncreaseBone defect healing
    Study

    guinea-pigsn: not reported in source

    femoral diaphysis bone defects
    Comparator
    Colladel without GHK
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Defects filled with Colladel without GHK healed substantially more quickly, and the most accelerated healing was connected with complete Colladel application.
    1 context sentence
    Summary · context
    The collagen gel supplemented with GHK, pefloxacine and HSGAG was named Colladel, and was used in a model experiment in guinea-pigs for filling artificially created bone defects in diaphyses of femurs, and with cementless endoprostheses.

Studies that did not test the peptide alone4

In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHK (glycyl-L-histidyl-L-lysine).

  1. 02AnimalNot a test of GHK (glycyl-L-histidyl-L-lysine) aloneAnimal study (in vivo)Other

    In rats, absorption of the supplemented collagen gel was slower than absorption of gel without HSGAG.

    In plain wordsIn rats, the supplemented collagen gel absorbed more slowly than gel without HSGAG.

    Peptide
    GHK (glycyl-L-histidyl-L-lysine)
    Outcome
    DecreaseGel absorption
    Study

    ratsn: not reported in source

    subcutaneous collagen gel sponges
    Comparator
    Gel without HSGAG
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    The absorption of gel without HSGAG was found to be faster.
    1 context sentence
    Summary · context
    The authors prepared 7.5% and 12.5% collagen gel, and supplemented it with the tripeptide Gly-His-Lys (GHK), perfloxacine and hypersulphated glycosaminoglycan (HSGAG). By means of 125l marking, its absorption was followed from small polyurethane sponges placed under the skin of rats.

    In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK (glycyl-L-histidyl-L-lysine).

  2. 03AnimalNot a test of GHK (glycyl-L-histidyl-L-lysine) aloneAnimal study (in vivo)Efficacy outcome

    In guinea-pig bone defects, complete Colladel had the most accelerated healing, while unfilled defects had the slowest healing.

    In plain wordsIn guinea-pigs, complete Colladel accelerated bone healing compared with unfilled defects.

    Peptide
    GHK (glycyl-L-histidyl-L-lysine)
    Outcome
    IncreaseBone defect healing
    Study

    guinea-pigsn: not reported in source

    femoral diaphysis bone defects
    Comparator
    Unfilled bone defects
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    The slowest healing process was found in unfilled bone defects. Defects filled with Colladel without GHK healed substantially more quickly, and the most accelerated healing was connected with complete Colladel application.
    1 context sentence
    Summary · context
    The collagen gel supplemented with GHK, pefloxacine and HSGAG was named Colladel, and was used in a model experiment in guinea-pigs for filling artificially created bone defects in diaphyses of femurs, and with cementless endoprostheses.

    In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK (glycyl-L-histidyl-L-lysine).

  3. 04AnimalNot a test of GHK (glycyl-L-histidyl-L-lysine) aloneAnimal study (in vivo)Efficacy outcome

    In guinea-pigs with cementless endoprostheses, Colladel showed vivid osteogenic activity at the trabecular bone-metal stem interface.

    In plain wordsIn guinea-pigs with cementless endoprostheses, Colladel showed bone-forming activity at the bone-metal interface.

    Peptide
    GHK (glycyl-L-histidyl-L-lysine)
    Outcome
    Not applicableInterface osteogenic activity
    Study

    guinea-pigsn: not reported in source

    cementless endoprostheses
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    When Colladel was used with cementless endoprostheses, vivid osteogenic activity at the interface of trabecular bone and metal stem was detectable in the course of the experiment.
    1 context sentence
    Summary · context
    The collagen gel supplemented with GHK, pefloxacine and HSGAG was named Colladel, and was used in a model experiment in guinea-pigs for filling artificially created bone defects in diaphyses of femurs, and with cementless endoprostheses.

    In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK (glycyl-L-histidyl-L-lysine).

  4. 05LabNot a test of GHK (glycyl-L-histidyl-L-lysine) aloneIn vitro (cell-free)Activity measurement

    In microbiological tests, the supplemented collagen gel was sterile.

    In plain wordsIn lab tests, the supplemented collagen gel was sterile.

    Peptide
    GHK (glycyl-L-histidyl-L-lysine)
    Outcome
    Not applicableGel sterility
    Study

    n: not reported in source

    collagen gel microbiological tests
    Outcome group
    Infection and antimicrobial activity · Infection

    Source sentences

    Summary
    Microbiological tests proved the sterility of the collagen gel.
    1 context sentence
    Summary · context
    The authors prepared 7.5% and 12.5% collagen gel, and supplemented it with the tripeptide Gly-His-Lys (GHK), perfloxacine and hypersulphated glycosaminoglycan (HSGAG).

    In this study, GHK (glycyl-L-histidyl-L-lysine) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHK (glycyl-L-histidyl-L-lysine).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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