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Study · In vitro (cells) · chick embryo · 1996

4 results

Death of cultured telencephalon neurons induced by glutamate is reduced by the peptide derivative Cerebrolysin.

Hutter-Paier B, Grygar E, Windisch M

Journal of neural transmission. Supplementum1 Jan 1996Cited by 24 (Europe PMC)

PMID8841972 (opens in a new tab)DOI10.1007/978-3-7091-6892-9_19 (opens in a new tab)PepBankPUB-08841972
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In chick embryo neuron cultures, Cerebrolysin prevented acute glutamate toxicity in a concentration-dependent manner.

    In plain wordsIn cells from chick embryos, Cerebrolysin reduced glutamate toxicity compared with untreated cells.

    Peptide
    Cerebrolysin
    Outcome
    DecreaseGlutamate neurotoxicity
    Study

    chick embryon: not reported in source

    Cultured telencephalon neurons exposed to glutamate
    Comparator
    Untreated control cells
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · 8 days of precultureAs given in this study (chick embryo).

    Source sentences

    Summary
    Toxic effects of acute glutamate exposure were prevented by Cerebrolysin in a concentration-dependent manner.
    1 context sentence
    Summary · context
    We have studied the effects of exogenous glutamate on survival of neurons from chick embryo telencephalon, precultured with a peptide derivative for 8 days.
  2. 02LabIn vitro (cells)Efficacy outcome

    In chick embryo neuron cultures exposed to glutamate, 20 microliters Cerebrolysin produced neuroprotective effects compared with untreated cells.

    In plain wordsIn cells from chick embryos, 20 microliters Cerebrolysin produced neuroprotective effects compared with untreated cells.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseNeuroprotection at lower concentration
    Study

    chick embryon: not reported in source

    Cultured telencephalon neurons exposed to glutamate
    Comparator
    Untreated control cells
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    20 microliters · 8 days of precultureAs given in this study (chick embryo).

    Source sentences

    Summary
    20 and 40 microliters Cerebrolysin produce distinct neuroprotective effects.
    1 context sentence
    Summary · context
    We have studied the effects of exogenous glutamate on survival of neurons from chick embryo telencephalon, precultured with a peptide derivative for 8 days.
  3. 03LabIn vitro (cells)Efficacy outcome

    In chick embryo neuron cultures exposed to glutamate, 40 microliters Cerebrolysin produced neuroprotective effects compared with untreated cells.

    In plain wordsIn cells from chick embryos, 40 microliters Cerebrolysin produced neuroprotective effects compared with untreated cells.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseNeuroprotection at intermediate concentration
    Study

    chick embryon: not reported in source

    Cultured telencephalon neurons exposed to glutamate
    Comparator
    Untreated control cells
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    40 microliters · 8 days of precultureAs given in this study (chick embryo).

    Source sentences

    Summary
    20 and 40 microliters Cerebrolysin produce distinct neuroprotective effects.
    1 context sentence
    Summary · context
    We have studied the effects of exogenous glutamate on survival of neurons from chick embryo telencephalon, precultured with a peptide derivative for 8 days.
  4. 04LabIn vitro (cells)Efficacy outcome

    In chick embryo neuron cultures, 80 microliters Cerebrolysin/ml medium more than doubled viability compared with untreated control cells.

    In plain wordsIn cells from chick embryos, Cerebrolysin more than doubled neuronal viability compared with untreated control cells.

    Peptide
    Cerebrolysin
    Outcome
    IncreaseNeuronal viability
    Study

    chick embryon: not reported in source

    Cultured telencephalon neurons exposed to glutamate
    Comparator
    Untreated control cells
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    80 microliters/ml nutrition medium · 8 days of precultureAs given in this study (chick embryo).

    Source sentences

    Summary
    However, 80 microliters Cerebrolysin/ml nutrition medium more than doubles neuronal viability compared to untreated control cells.
    1 context sentence
    Summary · context
    We have studied the effects of exogenous glutamate on survival of neurons from chick embryo telencephalon, precultured with a peptide derivative for 8 days.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

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