Skip to content

Study · Animal study (in vivo) · rat · 1996

6 results

Facilitation and attenuation of social recognition in rats by different oxytocin-related peptides.

Popik P, Vetulani J, Van Ree JM

European journal of pharmacology1 Jul 1996Cited by 31 (Europe PMC)

PMID8840121 (opens in a new tab)DOI10.1016/0014-2999(96)00215-4 (opens in a new tab)PepBankPUB-08840121
Publisher pagePubMedAsk about this study
Jump to 6 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, subcutaneous oxytocin at 0.6 and 6 micrograms/kg attenuated social recognition.

    In plain wordsIn rats, oxytocin at microgram doses weakened social recognition memory.

    Peptide
    Oxytocin
    Outcome
    DecreaseSocial recognition (attenuation)
    Study

    ratn: not reported in source

    social recognition paradigm
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    0.6 and 6 micrograms/kg · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    The attenuation of social recognition by 0.6 and 6 micrograms/kg of oxytocin was mimicked
    1 context sentence
    Summary · context
    The memory-modulating effects of subcutaneously administered oxytocin and related peptides were investigated in the social recognition paradigm in rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, subcutaneous oxytocin at 0.6 and 6 ng/kg facilitated social recognition.

    In plain wordsIn rats, oxytocin at much lower nanogram doses improved social recognition memory.

    Peptide
    Oxytocin
    Outcome
    IncreaseSocial recognition (facilitation)
    Study

    ratn: not reported in source

    social recognition paradigm
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    0.6 and 6 ng/kg · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    The facilitation of social recognition by 0.6 and 6 ng/kg of oxytocin was mimicked
    1 context sentence
    Summary · context
    The memory-modulating effects of subcutaneously administered oxytocin and related peptides were investigated in the social recognition paradigm in rats.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PLG at 0.6 micrograms/kg attenuated social recognition, mimicking oxytocin at the same dose.

    In plain wordsIn rats, PLG at 0.6 micrograms/kg weakened social recognition, as oxytocin did at the same dose.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    DecreaseSocial recognition
    Study

    ratn: not reported in source

    social recognition paradigm
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    0.6 micrograms/kg · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    The attenuation of social recognition by 0.6 and 6 micrograms/kg of oxytocin was mimicked by the same doses of des-Gly8-oxytocin, [pGlu4, Cyt6]oxytocin-(4-9) and prolyl-leucyl-glycinamide (PLG) and by 0.6 micrograms/kg of oxytocin-(1-6) and [pGlu4,Cyt6]oxytocin-(4-8).
    1 context sentence
    Summary · context
    The memory-modulating effects of subcutaneously administered oxytocin and related peptides were investigated in the social recognition paradigm in rats.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PLG at 6 micrograms/kg attenuated social recognition, mimicking oxytocin at the same dose.

    In plain wordsIn rats, PLG at 6 micrograms/kg weakened social recognition, as oxytocin did at the same dose.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    DecreaseSocial recognition
    Study

    ratn: not reported in source

    social recognition paradigm
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    6 micrograms/kg · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    The attenuation of social recognition by 0.6 and 6 micrograms/kg of oxytocin was mimicked by the same doses of des-Gly8-oxytocin, [pGlu4, Cyt6]oxytocin-(4-9) and prolyl-leucyl-glycinamide (PLG) and by 0.6 micrograms/kg of oxytocin-(1-6) and [pGlu4,Cyt6]oxytocin-(4-8).
    1 context sentence
    Summary · context
    The memory-modulating effects of subcutaneously administered oxytocin and related peptides were investigated in the social recognition paradigm in rats.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PLG at 0.6 ng/kg facilitated social recognition, mimicking oxytocin at the same dose.

    In plain wordsIn rats, PLG at 0.6 ng/kg improved social recognition, as oxytocin did at the same dose.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    IncreaseSocial recognition
    Study

    ratn: not reported in source

    social recognition paradigm
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    0.6 ng/kg · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    The facilitation of social recognition by 0.6 and 6 ng/kg of oxytocin was mimicked by the same doses of PLG and LG but not by the other peptides and the amino acid glycine.
    1 context sentence
    Summary · context
    The memory-modulating effects of subcutaneously administered oxytocin and related peptides were investigated in the social recognition paradigm in rats.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PLG at 6 ng/kg facilitated social recognition, mimicking oxytocin at the same dose.

    In plain wordsIn rats, PLG at 6 ng/kg improved social recognition, as oxytocin did at the same dose.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    IncreaseSocial recognition
    Study

    ratn: not reported in source

    social recognition paradigm
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    6 ng/kg · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    The facilitation of social recognition by 0.6 and 6 ng/kg of oxytocin was mimicked by the same doses of PLG and LG but not by the other peptides and the amino acid glycine.
    1 context sentence
    Summary · context
    The memory-modulating effects of subcutaneously administered oxytocin and related peptides were investigated in the social recognition paradigm in rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 4 to 9Current

    28 Oct 2026, 02:03 UTC

    The same notice was added 6 times, first on 22 Oct 2026, 02:26 UTC. The status did not change between them.

    Study results updated

  2. Version 3

    21 Oct 2026, 18:59 UTC

    Study data updated · source update from Europe PMC

  3. Version 2

    11 Oct 2026, 20:03 UTC

    Study results updated

  4. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.