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Study · Animal study (in vivo) · mouse and rat · 1996

5 results

A study of antitumor effects of thymosin on rat and mouse urinary bladder carcinoma induced by N-butyl-N-(4-hydroxybutyl)-nitrosamine.

Wada S, Kinoshita Y, Kamizuru M, Asai Y, Iwata H, Ikemoto S, Hato F, Kishimoto T, Fukushima S

Oncology research1 Jan 1996Cited by 1 (Europe PMC)

PMID8823810 (opens in a new tab)PepBankPUB-08823810
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats given BBN, bladder weights did not differ significantly between thymosin alpha‑1-treated and saline-treated groups at week 30.

    In plain wordsIn rats with induced bladder cancer, thymosin alpha‑1 did not change bladder weight compared with saline.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeBladder weight in BBN-treated rats
    Study

    ratn: not reported in source

    BBN-induced bladder carcinoma, female Wistar rats
    Comparator
    Normal saline (control)
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated · intramuscularAs given in this study (rat).

    Source sentences

    Summary
    However, these parameters were not significantly different between the T alpha 1-treated group and control saline-treated group.
    3 context sentences
    Summary · context
    At the 30th week of BBN oral administration, weights of urinary bladder were different among the three groups.
    Summary · context
    N-Butyl-N-(4-hydroxybutyl)-nitrosamine (BBN), which induces bladder carcinoma in female Wistar rats and female C3H/HeJ mice, was given as 0.025% (w/v) solution to rats and 0.05% to mice in the drinking water.
    Summary · context
    Thymosin fraction 5 (TF5) or thymosin alpha 1 (T alpha 1) dissolved in normal saline, and normal saline (control) respectively were injected into the right thigh IM twice a week in the experimental rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats given BBN, the incidence of bladder carcinoma did not differ significantly between thymosin alpha‑1-treated and saline-treated groups.

    In plain wordsIn rats with induced bladder cancer, thymosin alpha‑1 did not change how many developed bladder cancer compared with saline.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeIncidence of bladder carcinoma in BBN-treated rats
    Study

    ratn: not reported in source

    BBN-induced bladder carcinoma, female Wistar rats
    Comparator
    Normal saline (control)
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated · intramuscularAs given in this study (rat).

    Source sentences

    Summary
    However, these parameters were not significantly different between the T alpha 1-treated group and control saline-treated group.
    3 context sentences
    Summary · context
    Bladder weights and incidence of bladder carcinoma were significantly lower in the TF5-treated group as compared with control group.
    Summary · context
    N-Butyl-N-(4-hydroxybutyl)-nitrosamine (BBN), which induces bladder carcinoma in female Wistar rats and female C3H/HeJ mice, was given as 0.025% (w/v) solution to rats and 0.05% to mice in the drinking water.
    Summary · context
    Thymosin fraction 5 (TF5) or thymosin alpha 1 (T alpha 1) dissolved in normal saline, and normal saline (control) respectively were injected into the right thigh IM twice a week in the experimental rats.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats given BBN, natural killer cell activity of splenic lymphoid cells did not differ significantly between thymosin alpha‑1-treated and saline-treated groups.

    In plain wordsIn rats with induced bladder cancer, thymosin alpha‑1 did not change natural killer cell activity compared with saline.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeNatural killer cell activity of splenic lymphoid cells in rats
    Study

    ratn: not reported in source

    BBN-induced bladder carcinoma, female Wistar rats
    Comparator
    Normal saline (control)
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · intramuscularAs given in this study (rat).

    Source sentences

    Summary
    However, these parameters were not significantly different between the T alpha 1-treated group and control saline-treated group.
    3 context sentences
    Summary · context
    Natural killer cell activity of splenic lymphoid cells was significantly elevated in the TF5-treated group as compared with the control group.
    Summary · context
    N-Butyl-N-(4-hydroxybutyl)-nitrosamine (BBN), which induces bladder carcinoma in female Wistar rats and female C3H/HeJ mice, was given as 0.025% (w/v) solution to rats and 0.05% to mice in the drinking water.
    Summary · context
    Thymosin fraction 5 (TF5) or thymosin alpha 1 (T alpha 1) dissolved in normal saline, and normal saline (control) respectively were injected into the right thigh IM twice a week in the experimental rats.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice given BBN, bladder weights did not differ significantly among thymosin fraction 5, thymosin alpha‑1 and saline groups at 10, 15, 20 and 25 weeks.

    In plain wordsIn mice with induced bladder cancer, thymosin alpha‑1 did not change bladder weight compared with saline.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeBladder weight in BBN-treated mice
    Study

    mousen: not reported in source

    BBN-induced bladder carcinoma, female C3H/HeJ mice
    Comparator
    Normal saline (control)
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    On the other hand, bladder weights and incidence of bladder carcinoma were not significantly different among TF5-, T alpha 1- and saline-treated groups at 10, 15, 20, and 25 weeks of BBN administration in mice according to the same protocol as rats.
    2 context sentences
    Summary · context
    N-Butyl-N-(4-hydroxybutyl)-nitrosamine (BBN), which induces bladder carcinoma in female Wistar rats and female C3H/HeJ mice, was given as 0.025% (w/v) solution to rats and 0.05% to mice in the drinking water.
    Summary · context
    Thymosin fraction 5 (TF5) or thymosin alpha 1 (T alpha 1) dissolved in normal saline, and normal saline (control) respectively were injected into the right thigh IM twice a week in the experimental rats.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice given BBN, the incidence of bladder carcinoma did not differ significantly among thymosin fraction 5, thymosin alpha‑1 and saline groups at 10, 15, 20 and 25 weeks.

    In plain wordsIn mice with induced bladder cancer, thymosin alpha‑1 did not change how many developed bladder cancer compared with saline.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeIncidence of bladder carcinoma in BBN-treated mice
    Study

    mousen: not reported in source

    BBN-induced bladder carcinoma, female C3H/HeJ mice
    Comparator
    Normal saline (control)
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    On the other hand, bladder weights and incidence of bladder carcinoma were not significantly different among TF5-, T alpha 1- and saline-treated groups at 10, 15, 20, and 25 weeks of BBN administration in mice according to the same protocol as rats.
    2 context sentences
    Summary · context
    N-Butyl-N-(4-hydroxybutyl)-nitrosamine (BBN), which induces bladder carcinoma in female Wistar rats and female C3H/HeJ mice, was given as 0.025% (w/v) solution to rats and 0.05% to mice in the drinking water.
    Summary · context
    Thymosin fraction 5 (TF5) or thymosin alpha 1 (T alpha 1) dissolved in normal saline, and normal saline (control) respectively were injected into the right thigh IM twice a week in the experimental rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

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