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Study · Randomized controlled trial · n = 350 · 1996

3 results

A prospective, randomised study to compare goserelin acetate (Zoladex) versus cyproterone acetate (Cyprostat) versus a combination of the two in the treatment of metastatic prostatic carcinoma.

Thorpe SC, Azmatullah S, Fellows GJ, Gingell JC, O'Boyle PJ

European urology1 Jan 1996Cited by 36 (Europe PMC)

PMID8821690 (opens in a new tab)DOI10.1159/000473717 (opens in a new tab)PepBankPUB-08821690
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In metastatic prostate cancer, goserelin alone prolonged median time to progression versus cyproterone acetate alone, p = 0.016.

    In plain wordsGoserelin alone prolonged time to progression versus cyproterone acetate alone in metastatic prostate cancer.

    Peptide
    Goserelin
    Outcome
    IncreaseMedian time to progression
    Study

    n = 350

    Comparator
    Cyproterone acetate alone
    Outcome group
    Tumor growth · Cancer
    Studied dose
    3.6 mg every 28 daysAs given in this study (human).

    Measurements

    P value
    0.016 p
    goserelin acetate alone vs cyproterone acetate alone

    Source sentences

    Summary
    although there was a statistically significant difference between goserelin acetate alone and cyproterone acetate alone, in favour of goserelin acetate (p = 0.016).
    2 context sentences
    Summary · context
    A prospective randomised study was performed to test the hypothesis that total androgen ablation, achieved by combining an LHRH analogue, goserelin acetate (Zoladex), with an antiandrogen, cyproterone acetate (Cyprostat), is more effective than conventional monotherapy in delaying the time to progre…
    Summary · context
    525 patients were recruited at 18 UK centres between May 1986 and January 1989, 175 patients being allocated to each arm.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In metastatic prostate cancer, adding goserelin to cyproterone acetate did not significantly change median time to progression versus cyproterone acetate alone.

    In plain wordsAdding goserelin to cyproterone acetate did not significantly change time to progression versus cyproterone acetate alone.

    Peptide
    Goserelin
    Outcome
    No significant changeMedian time to progression
    Study

    n = 350

    Comparator
    Cyproterone acetate alone
    Outcome group
    Tumor growth · Cancer
    Studied dose
    3.6 mg every 28 daysAs given in this study (human).

    Source sentences

    Summary
    There was no statistically significant difference in terms of median time to progression between the combination treatment arm and either monotherapy arm
    2 context sentences
    Summary · context
    A prospective randomised study was performed to test the hypothesis that total androgen ablation, achieved by combining an LHRH analogue, goserelin acetate (Zoladex), with an antiandrogen, cyproterone acetate (Cyprostat), is more effective than conventional monotherapy in delaying the time to progre…
    Summary · context
    525 patients were recruited at 18 UK centres between May 1986 and January 1989, 175 patients being allocated to each arm.
  3. 03HumanNon-randomized trialSafety outcome

    In metastatic prostate cancer, goserelin monotherapy was well tolerated, as were the other regimens.

    In plain wordsGoserelin monotherapy was well tolerated in metastatic prostate cancer.

    Peptide
    Goserelin
    Outcome
    Not applicableTolerability
    Study

    n = 175

    Outcome group
    Adverse events · Cancer
    Studied dose
    3.6 mg every 28 daysAs given in this study (human).

    Source sentences

    Summary
    All treatment regimens were well tolerated
    2 context sentences
    Summary · context
    A prospective randomised study was performed to test the hypothesis that total androgen ablation, achieved by combining an LHRH analogue, goserelin acetate (Zoladex), with an antiandrogen, cyproterone acetate (Cyprostat), is more effective than conventional monotherapy in delaying the time to progre…
    Summary · context
    525 patients were recruited at 18 UK centres between May 1986 and January 1989, 175 patients being allocated to each arm.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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