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Study · Animal study (in vivo) · rat · 1996

5 results

Effect of dermorphin on thermoregulation in rats at selected ambient temperatures.

Emel'yanova TG, Usenko AB, Deigin VI, Yarova EP, Kamensky AA

Peptides1 Jan 1996Cited by 9 (Europe PMC)

PMID8801528 (opens in a new tab)DOI10.1016/0196-9781(95)02132-9 (opens in a new tab)PepBankPUB-08801528
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Activity measurement

    In rats, dermorphin caused dose-dependent changes in tail skin temperature.

    In plain wordsIn rats, dermorphin changed tail skin temperature in a dose-dependent manner.

    Peptide
    Dermorphin
    Outcome
    Direction not reportedDose-dependent tail skin temperature changes
    Study

    ratn: not reported in source

    Rats at selected ambient temperatures
    Outcome group
    Body temperature · Whole body
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Intraperitoneal administration of dermorphin caused dose-dependent changes in rats core temperature and tail skin temperature (indicative of compensatory thermoregulatory vasoreactions in rats).
  2. 02AnimalAnimal study (in vivo)Activity measurement

    In rats at 4-7 degrees C, dermorphin caused significant stable dose-dependent hypothermia.

    In plain wordsIn rats at 4-7 degrees C, dermorphin caused significant stable cooling that depended on dose.

    Peptide
    Dermorphin
    Outcome
    DecreaseCore temperature in cold environment
    Study

    ratn: not reported in source

    Rats in a cold environment
    Outcome group
    Body temperature · Whole body
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    In the cold environment (4-7 degrees C) dermorphin caused a significant, stable, dose-dependent hypothermia.
  3. 03AnimalAnimal study (in vivo)Activity measurement

    In rats at 27-28 degrees C, dermorphin caused less pronounced hypothermia than in the cold environment.

    In plain wordsIn rats at 27-28 degrees C, dermorphin caused less cooling than in the cold environment.

    Peptide
    Dermorphin
    Outcome
    DecreaseCore temperature in thermoneutral environment
    Study

    ratn: not reported in source

    Rats in a thermoneutral environment
    Comparator
    Cold environment at 4-7 degrees C
    Outcome group
    Body temperature · Whole body
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    In the thermoneutral environment (27-28 degrees C) dermorphin also caused hypothermia, but this effect was less pronounced.
    1 context sentence
    Summary · context
    In the cold environment (4-7 degrees C) dermorphin caused a significant, stable, dose-dependent hypothermia.
  4. 04AnimalAnimal study (in vivo)Activity measurement

    In rats at 31-32 degrees C, dermorphin caused hyperthermia.

    In plain wordsIn rats at 31-32 degrees C, dermorphin increased body temperature.

    Peptide
    Dermorphin
    Outcome
    IncreaseCore temperature in hot environment
    Study

    ratn: not reported in source

    Rats in a hot environment
    Outcome group
    Body temperature · Whole body
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    In the hot environment (31-32 degrees C) dermorphin caused hyperthermia.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats, dermorphin-related tail skin temperature changes indicated suppression of peripheral compensatory vasomotor reactions.

    In plain wordsIn rats, tail skin temperature changes indicated that dermorphin suppressed compensatory blood vessel responses.

    Peptide
    Dermorphin
    Outcome
    DecreasePeripheral compensatory vasomotor reactions
    Study

    ratn: not reported in source

    Rats at selected ambient temperatures
    Outcome group
    Body temperature · Whole body
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Dermorphin-induced changes in tail skin temperature indicate that dermorphin suppresses the thermoregulatory peripheral compensatory vasomotor reactions.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

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