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Study · Not a test of the peptide alone · 1996

1 result

Conjugation of glutathione with a toxic metabolite of valproic acid, (E)-2-propyl-2,4-pentadienoic acid, catalyzed by rat hepatic glutathione-S-transferases.

Tang W, Borel AG, Abbott FS

Drug metabolism and disposition: the biological fate of chemicals1 Apr 1996Cited by 29 (Europe PMC)

PMID8801059 (opens in a new tab)DOI10.1016/s0090-9556(25)07371-4 (opens in a new tab)PepBankPUB-08801059
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone1

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01LabNot a test of Oxytocin aloneIn vitro (cell-free)Mechanism

    In a separate experiment, the valproic acid metabolite mimic 2,4-diene VPA-NACA alkylated reduced oxytocin through one or both cysteine residues.

    In plain wordsIn lab tests, a mimic of a toxic valproic acid metabolite chemically attached to reduced oxytocin at its cysteine residues.

    Peptide
    Oxytocin
    Outcome
    Not applicableAlkylation of reduced oxytocin by 2,4-diene VPA-NACA
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    In a separate experiment, 2,4-diene VPA-NACA was observed to alkylate reduced oxytocin through one or both cysteine residues.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:54 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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