In mice infected with influenza A PR8 virus, amantadine plus thymosin alpha‑1 followed by IFN gave significantly better long-term survival than single agents with chemotherapy or chemotherapy alone.
In plain wordsIn infected mice, a combination of amantadine, thymosin alpha‑1 and interferon improved long-term survival compared with single agents plus amantadine or amantadine alone.
- Peptide
- Thymosin alpha-1
- Outcome
- IncreaseLong-term survival
- Study
mousen: not reported in source
mice infected with influenza A PR8 virus- Comparator
- Single agents with chemotherapy, chemotherapy alone
- Outcome group
- Mortality · Infection
Source sentences
The effectiveness of this new chemoimmunotherapy protocol was seen in the long-term survival of a high percentage of animals and was statistically significant when compared to treatment with single agents in conjunction with chemotherapy or to chemotherapy alone.
2 context sentences(design, population, supporting numbers)
The aim of this study was to examine the effects of the antiviral drug amantadine (AMN) administered in combination with thymosin alpha 1 (T alpha 1) and murine alpha/beta interferon (IFN) on mice infected with influenza A PR8 virus.
Combined treatment with AMN and T alpha 1, for 4 days, followed by a single injection of IFN, was initiated 1 h after intranasal viral inoculation.
In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.