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Study · In vitro (cells) · mouse · 1996

4 results

Differential expression of vasoactive intestinal peptide receptors 1 and 2 (VIP-R1 and VIP-R2) mRNA in murine lymphocytes.

Delgado M, Martinez C, Johnson MC, Gomariz RP, Ganea D

Journal of neuroimmunology1 Aug 1996Cited by 84 (Europe PMC)

PMID8784257 (opens in a new tab)DOI10.1016/0165-5728(96)00063-x (opens in a new tab)PepBankPUB-08784257
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In murine T lymphocytes, VIP induced the expression of the VIP-R2 gene without additional stimuli.

    In plain wordsIn mouse immune cells, VIP switched on the gene for its second receptor type without other stimuli.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseVIP-R2 gene expression induced by VIP
    Study

    mousen: not reported in source

    lymphocytes and thymocytes
    Outcome group
    Receptor activity and mechanism · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    VIP induces the expression of the VIP-R2 gene in the absence of additional stimuli.
    1 context sentence
    Summary · context
    In this study, we investigate the expression of VIP-R1 and VIP-R2 mRNA in unstimulated and stimulated lymphocytes and thymocytes, and in various lymphocyte subpopulations.

Studies that did not test the peptide alone3

In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

  1. 02LabNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneIn vitro (cells)Mechanism

    In murine lymphocytes and thymocytes, VIP-R1 mRNA was constitutively expressed, but VIP-R2 mRNA was induced only after stimulation through the TCR-associated CD3 complex.

    In plain wordsIn mouse immune cells, one VIP receptor was always present, but the second appeared only after the cells were stimulated.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicableVIP-R1 and VIP-R2 mRNA expression pattern
    Study

    mousen: not reported in source

    lymphocytes and thymocytes
    Outcome group
    Receptor activity and mechanism · Immune and inflammation

    Source sentences

    Summary
    In contrast to VIP-R1 which is constitutively expressed, the expression of VIP-R2 is induced only following stimulation through the TCR-associated CD3 complex.
    1 context sentence
    Summary · context
    In this study, we investigate the expression of VIP-R1 and VIP-R2 mRNA in unstimulated and stimulated lymphocytes and thymocytes, and in various lymphocyte subpopulations.

    In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

  2. 03LabNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneIn vitro (cells)Mechanism

    In murine T cells, both CD4+ and CD8+ T cells expressed VIP-R1 and VIP-R2.

    In plain wordsIn mouse immune cells, both major T cell types carried both VIP receptor types.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicableVIP-R1 and VIP-R2 expression in CD4+ and CD8+ T cells
    Study

    mousen: not reported in source

    lymphocytes and thymocytes
    Outcome group
    Receptor activity and mechanism · Immune and inflammation

    Source sentences

    Summary
    Both CD4+ and CD8+ T cells express VIP-R1 and VIP-R2.
    1 context sentence
    Summary · context
    In this study, we investigate the expression of VIP-R1 and VIP-R2 mRNA in unstimulated and stimulated lymphocytes and thymocytes, and in various lymphocyte subpopulations.

    In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

  3. 04LabNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneIn vitro (cells)Mechanism

    Two murine T cell lines, EL-4.IL-2 and D10.G4.1, expressed exclusively VIP-R2.

    In plain wordsIn mouse cell lines, two T cell lines carried only the second type of VIP receptor.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicableVIP receptor expression in T cell lines
    Study

    mousen: not reported in source

    lymphocytes and thymocytes
    Outcome group
    Receptor activity and mechanism · Immune and inflammation

    Source sentences

    Summary
    Two T cell lines, EL-4.IL-2 and D10.G4.1 express exclusively VIP-R2.
    1 context sentence
    Summary · context
    In this study, we investigate the expression of VIP-R1 and VIP-R2 mRNA in unstimulated and stimulated lymphocytes and thymocytes, and in various lymphocyte subpopulations.

    In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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