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Study · Non-randomized trial · 1996

6 results

Acute hormonal responses to the gonadotropin releasing hormone agonist leuprolide: dose-response studies and comparison to nafarelin--a clinical research center study.

Rosenfield RL, Perovic N, Ehrmann DA, Barnes RB

The Journal of clinical endocrinology and metabolism1 Sept 1996Cited by 26 (Europe PMC)

PMID8784105 (opens in a new tab)DOI10.1210/jcem.81.9.8784105 (opens in a new tab)PepBankPUB-08784105
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanNon-randomized trialActivity measurement

    In normal adults, leuprolide 10 micrograms/kg yielded LH responses similar to previously studied nafarelin 1-1.5 micrograms/kg.

    In plain wordsIn normal adults, leuprolide 10 micrograms/kg produced LH responses similar to previously studied nafarelin.

    Peptide
    Leuprolide
    Outcome
    No significant changeLH response
    Study

    n: not reported in source

    Comparator
    Previously obtained nafarelin responses
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    10 micrograms/kgAs given in this study (human).

    Source sentences

    Summary
    Leuprolide dose of 10 micrograms/kg yielded LH responses similar to 1-1.5 micrograms/kg nafarelin.
    2 context sentences
    Summary · context
    Normal adult men and women were randomized to receive leuprolide doses of 0.1, 1.0, or 10 micrograms/kg; a study extension evaluated doses up to 20 micrograms/kg in men.
    Summary · context
    The responses of LH, FSH, testosterone, and estradiol were monitored for 24 h, and the data were compared to those previously obtained on nafarelin.
  2. 02HumanNon-randomized trialActivity measurement

    In normal adults, leuprolide 10 micrograms/kg released less FSH than previously studied nafarelin.

    In plain wordsIn normal adults, leuprolide 10 micrograms/kg released less FSH than previously studied nafarelin.

    Peptide
    Leuprolide
    Outcome
    DecreaseFSH response
    Study

    n: not reported in source

    Comparator
    Previously obtained nafarelin responses
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    10 micrograms/kgAs given in this study (human).

    Source sentences

    Summary
    However, this leuprolide dose unexpectedly released less FSH than nafarelin.
    3 context sentences
    Summary · context
    Leuprolide dose of 10 micrograms/kg yielded LH responses similar to 1-1.5 micrograms/kg nafarelin.
    Summary · context
    Normal adult men and women were randomized to receive leuprolide doses of 0.1, 1.0, or 10 micrograms/kg; a study extension evaluated doses up to 20 micrograms/kg in men.
    Summary · context
    The responses of LH, FSH, testosterone, and estradiol were monitored for 24 h, and the data were compared to those previously obtained on nafarelin.
  3. 03HumanNon-randomized trialActivity measurement

    In normal adults, sex steroid responses to leuprolide were equivalent to or greater than those to previously studied nafarelin.

    In plain wordsIn normal adults, sex steroid responses to leuprolide were similar to or greater than those to previously studied nafarelin.

    Peptide
    Leuprolide
    Outcome
    MixedSex steroid responses
    Study

    n: not reported in source

    Comparator
    Previously obtained nafarelin responses
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Nevertheless, the gonadotropin responses were sufficient to elicit equivalent or greater sex steroid responses to leuprolide.
    2 context sentences
    Summary · context
    Normal adult men and women were randomized to receive leuprolide doses of 0.1, 1.0, or 10 micrograms/kg; a study extension evaluated doses up to 20 micrograms/kg in men.
    Summary · context
    The responses of LH, FSH, testosterone, and estradiol were monitored for 24 h, and the data were compared to those previously obtained on nafarelin.

Studies that did not test the peptide alone3

In this study, Leuprolide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Leuprolide.

  1. 04HumanNot a test of Leuprolide aloneObservational studyActivity measurement

    In adults challenged with GnRH agonists, men had greater LH release within the first hour than women.

    In plain wordsIn adults given GnRH agonists, including leuprolide, men released more LH within the first hour than women.

    Peptide
    Leuprolide
    Outcome
    IncreaseLH release within the first hour by sex
    Study

    n: not reported in source

    Comparator
    Women
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    These studies also further delineated sex-specific differences in pituitary responsiveness to challenge with GnRH agonists: men had a significantly lower baseline FSH level, greater LH release within the first hour, and lesser secretion of LH and FSH over the 24-h period.
    1 context sentence
    Summary · context
    Normal adult men and women were randomized to receive leuprolide doses of 0.1, 1.0, or 10 micrograms/kg; a study extension evaluated doses up to 20 micrograms/kg in men.

    In this study, Leuprolide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Leuprolide.

  2. 05HumanNot a test of Leuprolide aloneObservational studyActivity measurement

    In adults challenged with GnRH agonists, men had less LH secretion over 24 hours than women.

    In plain wordsIn adults given GnRH agonists, including leuprolide, men released less LH over 24 hours than women.

    Peptide
    Leuprolide
    Outcome
    DecreaseLH secretion over 24 hours by sex
    Study

    n: not reported in source

    Comparator
    Women
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    These studies also further delineated sex-specific differences in pituitary responsiveness to challenge with GnRH agonists: men had a significantly lower baseline FSH level, greater LH release within the first hour, and lesser secretion of LH and FSH over the 24-h period.
    1 context sentence
    Summary · context
    Normal adult men and women were randomized to receive leuprolide doses of 0.1, 1.0, or 10 micrograms/kg; a study extension evaluated doses up to 20 micrograms/kg in men.

    In this study, Leuprolide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Leuprolide.

  3. 06HumanNot a test of Leuprolide aloneObservational studyActivity measurement

    In adults challenged with GnRH agonists, men had less FSH secretion over 24 hours than women.

    In plain wordsIn adults given GnRH agonists, including leuprolide, men released less FSH over 24 hours than women.

    Peptide
    Leuprolide
    Outcome
    DecreaseFSH secretion over 24 hours by sex
    Study

    n: not reported in source

    Comparator
    Women
    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    These studies also further delineated sex-specific differences in pituitary responsiveness to challenge with GnRH agonists: men had a significantly lower baseline FSH level, greater LH release within the first hour, and lesser secretion of LH and FSH over the 24-h period.
    1 context sentence
    Summary · context
    Normal adult men and women were randomized to receive leuprolide doses of 0.1, 1.0, or 10 micrograms/kg; a study extension evaluated doses up to 20 micrograms/kg in men.

    In this study, Leuprolide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Leuprolide.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 2

    27 Oct 2026, 16:37 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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