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Study · Measured the body's own peptide · 1996

4 results

Anterior pituitary vasoactive intestinal peptide mRNA is colocalised with prolactin mRNA in hyperoestrogenised rats.

Chew LJ, Seah V, Murphy D, Carter D

Journal of molecular endocrinology1 Jun 1996Cited by 7 (Europe PMC)

PMID8782079 (opens in a new tab)DOI10.1677/jme.0.0160211 (opens in a new tab)PepBankPUB-08782079
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In chronically hyperoestrogenised rats, VIP RNA was detected in the anterior pituitary but not in untreated animals.

    In plain wordsIn rats, the body's own VIP message was found in the pituitary after long oestrogen treatment, but not in untreated rats.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    IncreaseVIP RNA in anterior pituitary
    Study

    ratn: not reported in source

    Comparator
    Untreated animals
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    In these studies, we have demonstrated by in situ hybridisation that VIP RNA is detected in the anterior pituitaries of chronically hyperoestrogenised rats, but not in those of untreated animals.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In the rat anterior pituitary, VIP RNA was present in a subpopulation of prolactin-producing cells.

    In plain wordsIn rats, the body's own VIP message was found inside some pituitary cells that make prolactin.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicableVIP RNA colocalisation with prolactin-producing cells
    Study

    ratn: not reported in source

    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Using a double-probe labelling procedure, VIP RNA has been shown to be present in a subpopulation of PRL-producing cells, while colocalisation of VIP and GH RNA was not observed.
    1 context sentence
    Summary · context
    We have generated a probe specific for the 1.7 kb transcript and double-labelling studies also showed definitive colocalisation with PRL mRNA.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In the rat anterior pituitary, VIP RNA did not colocalise with growth hormone RNA.

    In plain wordsIn rats, the body's own VIP message was not found in the same pituitary cells as growth hormone message.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    No significant changeVIP RNA colocalisation with growth hormone RNA
    Study

    ratn: not reported in source

    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    while colocalisation of VIP and GH RNA was not observed.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

  4. 04AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In the rat anterior pituitary, VIP gene expression showed two alternatively polyadenylated transcripts, 1.7 kb and 1.0 kb in size.

    In plain wordsIn rats, the body's own VIP gene in the pituitary made two message forms of different length.

    Peptide
    Vasoactive intestinal peptide (VIP, aviptadil)
    Outcome
    Not applicableVIP transcript sizes in anterior pituitary
    Study

    ratn: not reported in source

    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Measurements

    Transcript size
    1.7 kb
    VIP transcript 1
    Transcript size
    1 kb
    VIP transcript 2

    Source sentences

    Summary
    VIP gene expression in the rat anterior pituitary gland was characterised by the presence of two alternatively polyadenylated transcripts, 1.7 kb and 1.0 kb in size.

    This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 12:58 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 12:41 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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