In rat hypothalamic tissue, results suggested that simultaneous activation of both IGF receptor types was needed for IGF inhibition of GHRH release.
In plain wordsIn lab tests with rat tissue, results suggested that IGF inhibition of GHRH release required activation of both IGF receptor types.
- Peptide
- IGF-1 DES (des(1-3)IGF-I)
- Outcome
- DecreaseGHRH release
- Study
ratn: not reported in source
In vitro hypothalamic tissue- Outcome group
- Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Our results suggest that the simultaneous activation of type 1 and type 2 IGF receptors is needed for the negative feedback effect of IGFs on GHRH release in this in vitro system, in agreement with earlier findings in vivo.
1 context sentence(design, population, supporting numbers)
This study was designed to investigate the feedback loop between insulin-like growth factor-I (IGF-I) and IGF-II and the hypothalamic hormones growth hormone-releasing hormone (GHRH) and somatostatin (SS) using an in vitro rat hypothalamic model.
In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).