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Study · Measured the body's own peptide · 1996

3 results

Psychological disturbance alters thymic and adrenal hormone secretion in a parallel but independent manner.

Coe CL, Hall NR

Psychoneuroendocrinology1 Feb 1996Cited by 7 (Europe PMC)

PMID8774065 (opens in a new tab)DOI10.1016/0306-4530(95)00044-5 (opens in a new tab)PepBankPUB-08774065
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    In juvenile squirrel monkeys, circulating thymosin alpha‑1 fell significantly after social separation, together with increased adrenocortical activity.

    In plain wordsIn juvenile squirrel monkeys, the body's own thymosin alpha‑1 fell after separation from their social group.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseThymosin alpha 1 level after social separation
    Study

    squirrel monkeyn: not reported in source

    juvenile squirrel monkeys, social separation
    Outcome group
    Stress hormones · Endocrine and hormones

    Source sentences

    Summary
    Thymosin alpha 1 was significantly decreased after social separation in association with increased adrenocortical activity, especially during the first day after being housed alone.
    1 context sentence
    Summary · context
    Thymosin-alpha 1 (thymosin alpha 1) and cortisol levels were evaluated in juvenile squirrel monkeys to investigate the influence of psychological disturbance on thymic and adrenal hormone activity.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In a second study in squirrel monkeys, the fall in thymosin alpha‑1 levels was replicated and depended on psychosocial factors that changed the level of disturbance.

    In plain wordsIn squirrel monkeys, a second study again showed a fall in the body's own thymosin alpha‑1, linked to stress level.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseReplication of thymosin alpha 1 decrease in second study
    Study

    squirrel monkeyn: not reported in source

    juvenile squirrel monkeys, social separation
    Outcome group
    Stress hormones · Endocrine and hormones

    Source sentences

    Summary
    A second study verified that the decrement in thymosin alpha 1 levels was replicable and also sensitive to psychosocial factors that influence the level of induced disturbance.
    1 context sentence
    Summary · context
    Thymosin-alpha 1 (thymosin alpha 1) and cortisol levels were evaluated in juvenile squirrel monkeys to investigate the influence of psychological disturbance on thymic and adrenal hormone activity.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Other

    In squirrel monkeys, pharmacological inhibition of the cortisol response and of opiate hormone action partly attenuated the change in thymosin alpha‑1 secretion.

    In plain wordsIn squirrel monkeys, blocking cortisol or opiate action partly reduced the change in the body's own thymosin alpha‑1.

    Peptide
    Thymosin alpha-1
    Outcome
    MixedThymosin alpha 1 change after cortisol or opiate inhibition
    Study

    squirrel monkeyn: not reported in source

    juvenile squirrel monkeys, social separation
    Outcome group
    Stress hormones · Endocrine and hormones

    Source sentences

    Summary
    In addition, changes in thymosin secretion could be attenuated partially by pharmacological inhibition of the cortisol response and opiate hormone action.
    1 context sentence
    Summary · context
    Thymosin-alpha 1 (thymosin alpha 1) and cortisol levels were evaluated in juvenile squirrel monkeys to investigate the influence of psychological disturbance on thymic and adrenal hormone activity.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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