Vascular effects of oxytocin on human middle cerebral artery determined by transcranial Doppler sonography.

Stolz-Born G, Widder B, Born J

Regulatory peptides1 Apr 1996Cited by 7 (Europe PMC)

PMID8738880DOI10.1016/0167-0115(95)00168-9PepBankPUB-08738880

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

01HumanOther designEfficacy outcome
In six healthy participants in a double-blind crossover study, intravenous oxytocin reduced middle cerebral artery blood-flow velocity versus placebo within 10 min (P < 0.05).
In plain wordsIn six healthy people, oxytocin reduced brain-artery blood-flow velocity compared with placebo.
Peptide
Oxytocin
Outcome
DecreaseMiddle cerebral artery blood flow velocity
Study
n = 6
Comparator
Placebo
Outcome group
Cerebral blood flow · Cardiovascular
Studied dose
0.5 IU · intravenous infusion · 2.5 minAs given in this study (human).
Source sentences
Summary
Compared to placebo, intravenous infusion of OX (0.5 IU, within 2.5 min via a forearm catheter) reduced blood flow velocity (V) within 10 min after the start of the infusion (P < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
This double-blind cross-over study in healthy humans (n = 6) examined effects of oxytocin (OX) on blood flow in the middle cerebral artery (MCA) by transcranial Doppler sonography.
Report a problemFND-0873888001
02HumanOther designEfficacy outcome
In six healthy participants, the middle cerebral artery pulsatility index increased after intravenous oxytocin (P < 0.05).
In plain wordsIn six healthy people, a brain-artery pulsing measure increased after oxytocin infusion.
Peptide
Oxytocin
Outcome
IncreasePulsatility index of the middle cerebral artery
Study
n = 6
Outcome group
Cerebral blood flow · Cardiovascular
Studied dose
0.5 IU · intravenous infusion · 2.5 minAs given in this study (human).
Source sentences
Summary
The pulsatility index (PI) was at the same time increased following OX (P < 0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
Compared to placebo, intravenous infusion of OX (0.5 IU, within 2.5 min via a forearm catheter) reduced blood flow velocity (V) within 10 min after the start of the infusion (P < 0.05).
Summary · context
This double-blind cross-over study in healthy humans (n = 6) examined effects of oxytocin (OX) on blood flow in the middle cerebral artery (MCA) by transcranial Doppler sonography.
Report a problemFND-0873888002
03HumanOther designSafety outcome
In six healthy participants, oxytocin infusion was not accompanied by changes in expiratory endtidal pCO2.
In plain wordsIn six healthy people, oxytocin infusion was not accompanied by a change in breath carbon dioxide levels.
Peptide
Oxytocin
Outcome
No significant changeExpiratory endtidal pCO2
Study
n = 6
Outcome group
Adverse events · Cardiovascular
Studied dose
0.5 IU · intravenous infusion · 2.5 minAs given in this study (human).
Source sentences
Summary
The effects of OX were not accompanied by changes in expiratory endtidal pCO2
1 context sentence(design, population, supporting numbers)
Summary · context
This double-blind cross-over study in healthy humans (n = 6) examined effects of oxytocin (OX) on blood flow in the middle cerebral artery (MCA) by transcranial Doppler sonography.
Report a problemFND-0873888003
04HumanOther designSafety outcome
In six healthy participants, oxytocin infusion was not accompanied by changes in blood pressure.
In plain wordsIn six healthy people, oxytocin infusion was not accompanied by a change in blood pressure.
Peptide
Oxytocin
Outcome
No significant changeBlood pressure
Study
n = 6
Outcome group
Blood pressure · Cardiovascular
Studied dose
0.5 IU · intravenous infusion · 2.5 minAs given in this study (human).
Source sentences
Summary
The effects of OX were not accompanied by changes in expiratory endtidal pCO2 or blood pressure.
1 context sentence(design, population, supporting numbers)
Summary · context
This double-blind cross-over study in healthy humans (n = 6) examined effects of oxytocin (OX) on blood flow in the middle cerebral artery (MCA) by transcranial Doppler sonography.
Report a problemFND-0873888004
05HumanOther designSafety outcome
In six healthy participants, heart rate was slightly enhanced immediately after oxytocin infusion (P < 0.05).
In plain wordsIn six healthy people, heart rate rose slightly immediately after oxytocin infusion.
Peptide
Oxytocin
Outcome
IncreaseHeart rate
Study
n = 6
Outcome group
Heart function · Cardiovascular
Studied dose
0.5 IU · intravenous infusion · 2.5 minAs given in this study (human).
Source sentences
Summary
But, heart rate was slightly enhanced immediately after infusion of OX (P < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
This double-blind cross-over study in healthy humans (n = 6) examined effects of oxytocin (OX) on blood flow in the middle cerebral artery (MCA) by transcranial Doppler sonography.
Report a problemFND-0873888005

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:52 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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