Growth hormone-releasing hormone and somatostatin concentrations in the hypophysial portal blood of conscious sheep during the infusion of growth hormone-releasing peptide-6.

Fletcher TP, Thomas GB, Clarke IJ

Domestic animal endocrinology1 May 1996Cited by 38 (Europe PMC)

PMID8738866DOI10.1016/0739-7240(96)00017-3PepBankPUB-08738866

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In conscious ewes, GH concentration increased after GHRP‑6 bolus injection in six of nine animals.
In plain wordsIn sheep, growth hormone increased after GHRP‑6 injection in six of nine animals.
Peptide
GHRP-6
Outcome
IncreaseGH concentration after bolus
Study
sheepn = 9
conscious ewes
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
10 micrograms/kg bolus followed by 0.1 microgram/kg.hr infusion · 2 hr infusionAs given in this study (sheep).
Source sentences
Summary
An increase in plasma GH concentration was observed in the jugular samples of six of the nine ewes (1.4 +/- 0.3 vs 7.4 +/- 2.0 ng/ml, P < 0.05) 5-10 min after the GHRP-6 bolus injection, but in no case did we observe a significant coincident release of GHRH.
2 context sentences(design, population, supporting numbers)
Summary · context
Paired blood samples were collected from the hypophysial portal vessels and from the jugular vein of nine ewes for at least 2 hr.
Summary · context
The sheep were then given a bolus injection of 10 micrograms of GHRP-6 per kg followed by a 2-hr infusion of GHRP-6 (0.1 microgram/kg.hr).
Report a problemFND-0873886601
02AnimalAnimal study (in vivo)Mechanism
In conscious ewes, GHRP‑6 bolus injection produced no significant coincident GHRH release.
In plain wordsIn sheep, GHRP‑6 injection produced no significant coincident GHRH release.
Peptide
GHRP-6
Outcome
No significant changeCoincident GHRH release after bolus
Study
sheepn = 9
conscious ewes
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
10 micrograms/kg bolus followed by 0.1 microgram/kg.hr infusion · 2 hr infusionAs given in this study (sheep).
Source sentences
Summary
An increase in plasma GH concentration was observed in the jugular samples of six of the nine ewes (1.4 +/- 0.3 vs 7.4 +/- 2.0 ng/ml, P < 0.05) 5-10 min after the GHRP-6 bolus injection, but in no case did we observe a significant coincident release of GHRH.
2 context sentences(design, population, supporting numbers)
Summary · context
Paired blood samples were collected from the hypophysial portal vessels and from the jugular vein of nine ewes for at least 2 hr.
Summary · context
The sheep were then given a bolus injection of 10 micrograms of GHRP-6 per kg followed by a 2-hr infusion of GHRP-6 (0.1 microgram/kg.hr).
Report a problemFND-0873886602
03AnimalAnimal study (in vivo)Mechanism
In conscious ewes, mean GHRH levels did not significantly increase during GHRP‑6 infusion.
In plain wordsIn sheep, mean GHRH levels did not significantly increase during GHRP‑6 infusion.
Peptide
GHRP-6
Outcome
No significant changeMean GHRH during infusion
Study
sheepn = 9
conscious ewes
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
10 micrograms/kg bolus followed by 0.1 microgram/kg.hr infusion · 2 hr infusionAs given in this study (sheep).
Source sentences
Summary
During the infusion period, mean plasma GHRH levels were not significantly increased but there was a 50% increase (P < 0.05) in GHRH pulse frequency; GHRH pulse amplitude was not changed.
2 context sentences(design, population, supporting numbers)
Summary · context
Paired blood samples were collected from the hypophysial portal vessels and from the jugular vein of nine ewes for at least 2 hr.
Summary · context
The sheep were then given a bolus injection of 10 micrograms of GHRP-6 per kg followed by a 2-hr infusion of GHRP-6 (0.1 microgram/kg.hr).
Report a problemFND-0873886603
04AnimalAnimal study (in vivo)Mechanism
In conscious ewes, GHRH pulse frequency increased by 50% during GHRP‑6 infusion.
In plain wordsIn sheep, GHRH pulse frequency increased by 50% during GHRP‑6 infusion.
Peptide
GHRP-6
Outcome
IncreaseGHRH pulse frequency
Study
sheepn = 9
conscious ewes
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
10 micrograms/kg bolus followed by 0.1 microgram/kg.hr infusion · 2 hr infusionAs given in this study (sheep).
Measurements
GHRH pulse frequency increase
50%
during infusion
Source sentences
Summary
During the infusion period, mean plasma GHRH levels were not significantly increased but there was a 50% increase (P < 0.05) in GHRH pulse frequency; GHRH pulse amplitude was not changed.
2 context sentences(design, population, supporting numbers)
Summary · context
Paired blood samples were collected from the hypophysial portal vessels and from the jugular vein of nine ewes for at least 2 hr.
Summary · context
The sheep were then given a bolus injection of 10 micrograms of GHRP-6 per kg followed by a 2-hr infusion of GHRP-6 (0.1 microgram/kg.hr).
Report a problemFND-0873886604
05AnimalAnimal study (in vivo)Mechanism
In conscious ewes, GHRH pulse amplitude did not change during GHRP‑6 infusion.
In plain wordsIn sheep, GHRH pulse amplitude did not change during GHRP‑6 infusion.
Peptide
GHRP-6
Outcome
No significant changeGHRH pulse amplitude
Study
sheepn = 9
conscious ewes
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
10 micrograms/kg bolus followed by 0.1 microgram/kg.hr infusion · 2 hr infusionAs given in this study (sheep).
Source sentences
Summary
During the infusion period, mean plasma GHRH levels were not significantly increased but there was a 50% increase (P < 0.05) in GHRH pulse frequency; GHRH pulse amplitude was not changed.
2 context sentences(design, population, supporting numbers)
Summary · context
Paired blood samples were collected from the hypophysial portal vessels and from the jugular vein of nine ewes for at least 2 hr.
Summary · context
The sheep were then given a bolus injection of 10 micrograms of GHRP-6 per kg followed by a 2-hr infusion of GHRP-6 (0.1 microgram/kg.hr).
Report a problemFND-0873886605
06AnimalAnimal study (in vivo)Mechanism
In conscious ewes, GHRP‑6 did not change mean SRIF concentration.
In plain wordsIn sheep, GHRP‑6 did not change mean somatostatin concentration.
Peptide
GHRP-6
Outcome
No significant changeMean SRIF concentration
Study
sheepn = 9
conscious ewes
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
10 micrograms/kg bolus followed by 0.1 microgram/kg.hr infusion · 2 hr infusionAs given in this study (sheep).
Source sentences
Summary
Mean SRIF concentration, pulse frequency, and pulse amplitude were unchanged by GHRP-6 treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
Paired blood samples were collected from the hypophysial portal vessels and from the jugular vein of nine ewes for at least 2 hr.
Summary · context
The sheep were then given a bolus injection of 10 micrograms of GHRP-6 per kg followed by a 2-hr infusion of GHRP-6 (0.1 microgram/kg.hr).
Report a problemFND-0873886606
07AnimalAnimal study (in vivo)Mechanism
In conscious ewes, GHRP‑6 did not change SRIF pulse frequency.
In plain wordsIn sheep, GHRP‑6 did not change somatostatin pulse frequency.
Peptide
GHRP-6
Outcome
No significant changeSRIF pulse frequency
Study
sheepn = 9
conscious ewes
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
10 micrograms/kg bolus followed by 0.1 microgram/kg.hr infusion · 2 hr infusionAs given in this study (sheep).
Source sentences
Summary
Mean SRIF concentration, pulse frequency, and pulse amplitude were unchanged by GHRP-6 treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
Paired blood samples were collected from the hypophysial portal vessels and from the jugular vein of nine ewes for at least 2 hr.
Summary · context
The sheep were then given a bolus injection of 10 micrograms of GHRP-6 per kg followed by a 2-hr infusion of GHRP-6 (0.1 microgram/kg.hr).
Report a problemFND-0873886607
08AnimalAnimal study (in vivo)Mechanism
In conscious ewes, GHRP‑6 did not change SRIF pulse amplitude.
In plain wordsIn sheep, GHRP‑6 did not change somatostatin pulse amplitude.
Peptide
GHRP-6
Outcome
No significant changeSRIF pulse amplitude
Study
sheepn = 9
conscious ewes
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
10 micrograms/kg bolus followed by 0.1 microgram/kg.hr infusion · 2 hr infusionAs given in this study (sheep).
Source sentences
Summary
Mean SRIF concentration, pulse frequency, and pulse amplitude were unchanged by GHRP-6 treatment.
2 context sentences(design, population, supporting numbers)
Summary · context
Paired blood samples were collected from the hypophysial portal vessels and from the jugular vein of nine ewes for at least 2 hr.
Summary · context
The sheep were then given a bolus injection of 10 micrograms of GHRP-6 per kg followed by a 2-hr infusion of GHRP-6 (0.1 microgram/kg.hr).
Report a problemFND-0873886608

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PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

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