In rats and mice with endotoxin-induced inflammation, high thymulin doses significantly reduced mechanical hyperalgesia in a dose-dependent manner.
In plain wordsIn rats and mice with endotoxin-induced inflammation, high thymulin doses reduced sensitivity to pressure pain.
- Outcome
- DecreaseMechanical hyperalgesia
- Study
rats and micen: not reported in source
intraplantar endotoxin-induced localized inflammation- Outcome group
- Pain · Nervous system and cognition
- Studied dose
- High dosesAs given in this study (rats and mice).
Source sentences
High doses of thymulin reduced significantly, and in a dose-dependent manner, mechanical hyperalgesia as assessed by the paw pressure test and thermal hyperalgesia as assessed by the hot plate test and tail immersion test.
1 context sentence(design, population, supporting numbers)
In a new model of peripheral localized inflammation, induced by intraplantar endotoxin (1.25 micrograms) injection in the hind paw of rats and mice, thymulin, a hormone of the thymus gland involved in immunomodulation, reduced inflammatory pain.