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Study · Non-randomized trial · n = 24 · 1996

7 results

Growth hormone treatment affects brain neurotransmitters and thyroxine [see comment].

Burman P, Hetta J, Wide L, Månsson JE, Ekman R, Karlsson FA

Clinical endocrinology1 Mar 1996Cited by 81 (Europe PMC)

PMID8729530 (opens in a new tab)DOI10.1046/j.1365-2265.1996.617439.x (opens in a new tab)PepBankPUB-08729530
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

  1. 01HumanNon-randomized trialPharmacokinetics

    In adults with acquired GH deficiency, CSF GH concentration correlated with administered rhGH dose (r = 0.56, P = 0.0044).

    In plain wordsIn adults with acquired GH deficiency, higher rhGH doses were linked to higher GH concentrations in cerebrospinal fluid.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseCSF GH concentration and administered dose
    Study

    n = 24

    Outcome group
    Pharmacokinetics · Nervous system and cognition
    Studied dose
    Dose not stated · 9 monthsAs given in this study (human).

    Measurements

    Correlation coefficient
    0.56 r
    CSF GH and administered dose

    Source sentences

    Summary
    Analysis of CSF collected at the end of the two treatment periods showed that the GH concentration was related to the administered dose of rhGH (r = 0.56, P = 0.0044).
    2 context sentences
    Summary · context
    In a double-blind, placebo-controlled 21-month trial with a cross-over design, with each treatment period lasting for 9 months, we investigated the long-term effect of GH on the cerebrospinal fluid (CSF) concentrations of some brain neurotransmitters and thyroid hormones of importance for mood and cognition.
    Summary · context
    Twenty-four patients with documented GH deficiency acquired in adult life took part.
  2. 02HumanNon-randomized trialEfficacy outcome

    In adults with acquired GH deficiency, rhGH reduced CSF homovanillic acid from 218 +/- 80 to 193 +/- 82 nmol/l (P = 0.002).

    In plain wordsIn adults with acquired GH deficiency, cerebrospinal fluid homovanillic acid decreased after rhGH treatment.

    Peptide
    HGH (somatotropin)
    Outcome
    DecreaseCSF homovanillic acid
    Study

    n = 24

    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    Dose not stated · 9 monthsAs given in this study (human).

    Measurements

    Homovanillic acid
    218 nmol/l
    before
    Homovanillic acid
    193 nmol/l
    after rhGH

    Source sentences

    Summary
    After rhGH treatment the concentration of the dopamine metabolite homovanillic acid (HVA) had decreased from 218 +/- 80 to 193 +/- 82 nmol/l (P = 0.002)
    2 context sentences
    Summary · context
    In a double-blind, placebo-controlled 21-month trial with a cross-over design, with each treatment period lasting for 9 months, we investigated the long-term effect of GH on the cerebrospinal fluid (CSF) concentrations of some brain neurotransmitters and thyroid hormones of importance for mood and cognition.
    Summary · context
    Twenty-four patients with documented GH deficiency acquired in adult life took part.
  3. 03HumanNon-randomized trialEfficacy outcome

    In adults with acquired GH deficiency, CSF aspartate increased from 233 +/- 81 to 313 +/- 116 nmol/l after rhGH (P = 0.032).

    In plain wordsIn adults with acquired GH deficiency, cerebrospinal fluid aspartate increased after rhGH treatment.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseCSF aspartate
    Study

    n = 24

    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    Dose not stated · 9 monthsAs given in this study (human).

    Measurements

    Aspartate
    233 nmol/l
    before
    Aspartate
    313 nmol/l
    after rhGH

    Source sentences

    Summary
    After rhGH treatment the concentration of the dopamine metabolite homovanillic acid (HVA) had decreased from 218 +/- 80 to 193 +/- 82 nmol/l (P = 0.002) and that of the excitatory acid aspartate had increased from 233 +/- 81 to 313 +/- 116 nmol/l (P = 0.032).
    2 context sentences
    Summary · context
    In a double-blind, placebo-controlled 21-month trial with a cross-over design, with each treatment period lasting for 9 months, we investigated the long-term effect of GH on the cerebrospinal fluid (CSF) concentrations of some brain neurotransmitters and thyroid hormones of importance for mood and cognition.
    Summary · context
    Twenty-four patients with documented GH deficiency acquired in adult life took part.
  4. 04HumanNon-randomized trialEfficacy outcome

    In adults with acquired GH deficiency, rhGH had no observed effect on CSF 5-hydroxyindoleacetic acid, 3-methoxy-4-hydroxyphenyl glycol, glutamate, glycine, or beta-endorphin.

    In plain wordsIn adults with acquired GH deficiency, CSF serotonin and noradrenaline metabolites, glutamate, glycine, and beta-endorphin showed no observed change after rhGH.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant changeCSF monoamine metabolites, glutamate, glycine, and beta-endorphin
    Study

    n = 24

    Outcome group
    Neurotransmitters and neurotrophic factors · Nervous system and cognition
    Studied dose
    Dose not stated · 9 monthsAs given in this study (human).

    Source sentences

    Summary
    No effects were observed on the concentrations of 5-hydroxyindoleacetic acid (the serotonin metabolite) and of 3-methoxy-4-hydroxyphenyl glycol (the noradrenaline metabolite), or on those of glutamate, glycine and beta-endorphin.
    2 context sentences
    Summary · context
    In a double-blind, placebo-controlled 21-month trial with a cross-over design, with each treatment period lasting for 9 months, we investigated the long-term effect of GH on the cerebrospinal fluid (CSF) concentrations of some brain neurotransmitters and thyroid hormones of importance for mood and cognition.
    Summary · context
    Twenty-four patients with documented GH deficiency acquired in adult life took part.
  5. 05HumanNon-randomized trialEfficacy outcome

    In adults with acquired GH deficiency, rhGH reduced CSF free T4 from 19.8 +/- 6.1 to 16.6 +/- 5.7 nmol/l (P = 0.0002).

    In plain wordsIn adults with acquired GH deficiency, free T4 decreased in cerebrospinal fluid after rhGH treatment.

    Peptide
    HGH (somatotropin)
    Outcome
    DecreaseCSF free T4
    Study

    n = 24

    Outcome group
    Thyroid function · Endocrine and hormones
    Studied dose
    Dose not stated · 9 monthsAs given in this study (human).

    Measurements

    CSF free T4
    19.8 nmol/l
    before
    CSF free T4
    16.6 nmol/l
    after rhGH

    Source sentences

    Summary
    However, both CSF and serum levels of free T4 decreased, from 19.8 +/- 6.1 to 16.6 +/- 5.7 nmol/l (P = 0.0002) and 17.0 +/- 5.0 to 13.7 +/- 4.3 nmol/l (P = 0.0001), respectively.
    2 context sentences
    Summary · context
    In a double-blind, placebo-controlled 21-month trial with a cross-over design, with each treatment period lasting for 9 months, we investigated the long-term effect of GH on the cerebrospinal fluid (CSF) concentrations of some brain neurotransmitters and thyroid hormones of importance for mood and cognition.
    Summary · context
    Twenty-four patients with documented GH deficiency acquired in adult life took part.
  6. 06HumanNon-randomized trialEfficacy outcome

    In adults with acquired GH deficiency, rhGH reduced serum free T4 from 17.0 +/- 5.0 to 13.7 +/- 4.3 nmol/l (P = 0.0001).

    In plain wordsIn adults with acquired GH deficiency, serum free T4 decreased after rhGH treatment.

    Peptide
    HGH (somatotropin)
    Outcome
    DecreaseSerum free T4
    Study

    n = 24

    Outcome group
    Thyroid function · Endocrine and hormones
    Studied dose
    Dose not stated · 9 monthsAs given in this study (human).

    Measurements

    Serum free T4
    17 nmol/l
    before
    Serum free T4
    13.7 nmol/l
    after rhGH

    Source sentences

    Summary
    However, both CSF and serum levels of free T4 decreased, from 19.8 +/- 6.1 to 16.6 +/- 5.7 nmol/l (P = 0.0002) and 17.0 +/- 5.0 to 13.7 +/- 4.3 nmol/l (P = 0.0001), respectively.
    2 context sentences
    Summary · context
    In a double-blind, placebo-controlled 21-month trial with a cross-over design, with each treatment period lasting for 9 months, we investigated the long-term effect of GH on the cerebrospinal fluid (CSF) concentrations of some brain neurotransmitters and thyroid hormones of importance for mood and cognition.
    Summary · context
    Twenty-four patients with documented GH deficiency acquired in adult life took part.
  7. 07HumanNon-randomized trialEfficacy outcome

    In adults with acquired GH deficiency, serum total T3 increased from 1.41 to 1.53 nmol/l after rhGH (P = 0.01).

    In plain wordsIn adults with acquired GH deficiency, serum total T3 increased after rhGH treatment.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseSerum total T3
    Study

    n = 24

    Outcome group
    Thyroid function · Endocrine and hormones
    Studied dose
    Dose not stated · 9 monthsAs given in this study (human).

    Measurements

    Serum total T3
    1.41 nmol/l
    before
    Serum total T3
    1.53 nmol/l
    after rhGH

    Source sentences

    Summary
    The concentration of total T3 was not measurable in CSF but increased in serum from 1.41 to 1.53 nmol/l (P = 0.01).
    2 context sentences
    Summary · context
    In a double-blind, placebo-controlled 21-month trial with a cross-over design, with each treatment period lasting for 9 months, we investigated the long-term effect of GH on the cerebrospinal fluid (CSF) concentrations of some brain neurotransmitters and thyroid hormones of importance for mood and cognition.
    Summary · context
    Twenty-four patients with documented GH deficiency acquired in adult life took part.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

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