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Study · Measured the body's own peptide · 1996

3 results

IL-1, ICAM-1, LFA-3, and hydrocortisone differentially regulate cytokine secretion by human fetal thymic epithelial cells.

Shu S, Naylor P, Touraine JL, Hadden JW

Thymus1 Jan 1996Cited by 8 (Europe PMC)

PMID8728354 (opens in a new tab)PepBankPUB-08728354
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01LabEndogenous levelIn vitro (cells)Other

    Human fetal thymic epithelial cells secreted thymosin alpha‑1 constitutively.

    In plain wordsHuman fetal thymus cells in the lab made and released the body's own thymosin alpha‑1 without any stimulus.

    Peptide
    Thymosin alpha-1
    Outcome
    Not applicableConstitutive thymosin alpha 1 secretion
    Study

    humann: not reported in source

    human fetal thymic epithelial cells
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    TEC secreted constitutively IL-6, IL-8, fibronectin and thymosin alpha 1 but not GM-CSF of LIF.
    2 context sentences
    Summary · context
    Human fetal thymic epithelial cells (TEC) were cultured under serum-free conditions.
    Summary · context
    The TEC were analyzed for the secretion of 14C-labelled peptides and of IL-3, IL-6 IL-7, IL-8, GM-CSF, LIF, fibronectin and thymosin alpha 1 by ELISA tests.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  2. 02LabEndogenous levelIn vitro (cells)Other

    In human fetal thymic epithelial cells, none of the stimulants (IL-1, anti-ICAM-1, anti-LFA-3) augmented constitutive thymosin alpha‑1 secretion.

    In plain wordsIn human thymus cells in the lab, the stimulants tested did not raise the body's own thymosin alpha‑1 release.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeThymosin alpha 1 secretion after IL-1, anti-ICAM-1 or anti-LFA-3
    Study

    humann: not reported in source

    human fetal thymic epithelial cells
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    None of the stimulants augmented the constitutive secretion of fibronectin or thymosin alpha 1 and HC inhibited thymosin alpha 1 secretion.
    3 context sentences
    Summary · context
    Stimulants included recombinant IL-1 and monoclonal antibodies to the surface adhesion molecules ICAM-1 and LAF-3.
    Summary · context
    Human fetal thymic epithelial cells (TEC) were cultured under serum-free conditions.
    Summary · context
    The TEC were analyzed for the secretion of 14C-labelled peptides and of IL-3, IL-6 IL-7, IL-8, GM-CSF, LIF, fibronectin and thymosin alpha 1 by ELISA tests.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  3. 03LabEndogenous levelIn vitro (cells)Other

    In human fetal thymic epithelial cells, hydrocortisone inhibited thymosin alpha‑1 secretion.

    In plain wordsIn human thymus cells in the lab, hydrocortisone lowered the release of the body's own thymosin alpha‑1.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseThymosin alpha 1 secretion with hydrocortisone
    Study

    humann: not reported in source

    human fetal thymic epithelial cells
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    None of the stimulants augmented the constitutive secretion of fibronectin or thymosin alpha 1 and HC inhibited thymosin alpha 1 secretion.
    3 context sentences
    Summary · context
    In addition, hydrocortisone (2.7 x 10(-7) M) was used to dissect secretion patterns.
    Summary · context
    Human fetal thymic epithelial cells (TEC) were cultured under serum-free conditions.
    Summary · context
    The TEC were analyzed for the secretion of 14C-labelled peptides and of IL-3, IL-6 IL-7, IL-8, GM-CSF, LIF, fibronectin and thymosin alpha 1 by ELISA tests.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

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