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Study · Animal study (in vivo) · pig · 1995

8 results

A proposed role for oxytocin in regulation of endometrial prostaglandin F2 alpha secretion during luteolysis in swine.

Mirando MA, Prince BC, Tysseling KA, Carnahan KG, Ludwig TE, Hoagland TA, Crain RC

Advances in experimental medicine and biology1 Jan 1995Cited by 15 (Europe PMC)

PMID8713996 (opens in a new tab)PepBankPUB-08713996
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In cyclic gilts, exogenous OT given in late diestrus (days 10-16) shortened the interestrous interval in three of four experiments.

    In plain wordsIn pigs, oxytocin given late in the cycle shortened the time between heats in three of four experiments.

    Peptide
    Oxytocin
    Outcome
    DecreaseInterestrous interval
    Study

    pign: not reported in source

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Exogenous OT administered to cyclic gilts during late diestrus (days 10-16) decreased interestrous interval in three of four experiments.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In hysterectomized gilts, OT did not promote corpus luteum regression, so its effect depended on the uterus.

    In plain wordsIn pigs without a womb, oxytocin did not trigger regression of the corpus luteum.

    Peptide
    Oxytocin
    Outcome
    No significant changeCorpus luteum regression in hysterectomized gilts
    Study

    pign: not reported in source

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, OT did not promote CL regression in hysterectomized gilts indicating that the effect of OT was uterine-dependent.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In cyclic gilts, circulating 13,14-dihydro-15-keto PGF2 alpha increased 10 min after intravenous OT injection on days 14 and 16.

    In plain wordsIn cycling pigs, an oxytocin injection into a vein raised blood levels of a prostaglandin breakdown product within 10 minutes.

    Peptide
    Oxytocin
    Outcome
    IncreaseCirculating PGF2 alpha metabolite after OT in cyclic gilts
    Study

    pign: not reported in source

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · intravenousAs given in this study (pig).

    Source sentences

    Summary
    Circulating concentrations of 13,14-dihydro-15-keto PGF2 alpha (the major stable metabolite of PGF2 alpha) were increased (p < 0.01) 10 min after i.v. injection of OT on days 14 and 16 in cyclic gilts and on days 10-16 in pregnant gilts, but the magnitude of the response to OT on all days in pregnan…
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In pregnant gilts, circulating 13,14-dihydro-15-keto PGF2 alpha increased after intravenous OT injection on days 10-16.

    In plain wordsIn pregnant pigs, an oxytocin injection into a vein raised blood levels of a prostaglandin breakdown product.

    Peptide
    Oxytocin
    Outcome
    IncreaseCirculating PGF2 alpha metabolite after OT in pregnant gilts
    Study

    pign: not reported in source

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · intravenousAs given in this study (pig).

    Source sentences

    Summary
    Circulating concentrations of 13,14-dihydro-15-keto PGF2 alpha (the major stable metabolite of PGF2 alpha) were increased (p < 0.01) 10 min after i.v. injection of OT on days 14 and 16 in cyclic gilts and on days 10-16 in pregnant gilts, but the magnitude of the response to OT on all days in pregnan…
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    The rise in circulating PGF2 alpha metabolite after OT was markedly smaller in pregnant gilts than in cyclic gilts.

    In plain wordsIn pigs, the prostaglandin response to oxytocin was much smaller in pregnant pigs than in cycling pigs.

    Peptide
    Oxytocin
    Outcome
    DecreasePGF2 alpha metabolite response to OT, pregnant versus cyclic gilts
    Study

    pign: not reported in source

    Comparator
    Cyclic gilts
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · intravenousAs given in this study (pig).

    Source sentences

    Summary
    Circulating concentrations of 13,14-dihydro-15-keto PGF2 alpha (the major stable metabolite of PGF2 alpha) were increased (p < 0.01) 10 min after i.v. injection of OT on days 14 and 16 in cyclic gilts and on days 10-16 in pregnant gilts, but the magnitude of the response to OT on all days in pregnan…
  6. 06LabEx vivo tissueMechanism

    In pig endometrium, IP3 increased within 30 seconds after OT treatment and preceded the rise in PGF2 alpha release.

    In plain wordsIn pig womb lining, oxytocin raised a messenger molecule within 30 seconds, before prostaglandin release rose.

    Peptide
    Oxytocin
    Outcome
    IncreaseEndometrial IP3 after OT
    Study

    pign: not reported in source

    Pig endometrium
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Endometrial IP3 was increased within 30 seconds after OT treatment and preceded the increase in PGF2 alpha release stimulated by OT.
  7. 07LabEx vivo tissueMechanism

    In pig endometrium, oxytocin receptor density correlated with OT-stimulated PI hydrolysis (r = 0.83) and with OT-stimulated PGF2 alpha secretion (r = 0.87).

    In plain wordsIn pig womb lining, tissue with more oxytocin receptors responded more strongly to oxytocin.

    Peptide
    Oxytocin
    Outcome
    Not applicableEndometrial OTR density versus OT-stimulated PI hydrolysis and PGF2 alpha secretion
    Study

    pign: not reported in source

    Pig endometrium
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Density of OTR was correlated with OT-stimulated PI hydrolysis (r = 0.83, p < 0.05) and PGF2 alpha secretion (r = 0.87, p < 0.10).

Studies that did not test the peptide alone1

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 08LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In pig endometrium, 100 nM OT plus 100 nM lysine-vasopressin stimulated PI hydrolysis more than 100-200 nM OT or lysine-vasopressin alone.

    In plain wordsIn pig womb lining, oxytocin and lysine-vasopressin together stimulated more PI hydrolysis than either one alone.

    Peptide
    Oxytocin
    Outcome
    IncreasePI hydrolysis with OT plus lysine-vasopressin
    Study

    pign: not reported in source

    Pig endometrium
    Comparator
    OT or lysine-vasopressin alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Distinct receptors for OT and lysine-vasopressin on pig endometrium were confirmed by treatment with 100 nM OT + 100 nM lysine-vasopressin which stimulated PI hydrolysis more than 100-200 nM OT or lysine-vasopressin alone.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:53 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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