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Study · Measured the body's own peptide · 1995

6 results

Gonadal steroid regulation of oxytocin and oxytocin receptor gene expression.

Zingg HH, Rozen F, Breton C, Larcher A, Neculcea J, Chu K, Russo C, Arslan A

Advances in experimental medicine and biology1 Jan 1995Cited by 42 (Europe PMC)

PMID8713994 (opens in a new tab)PepBankPUB-08713994
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Natural levels measured6

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In rats at term, the uterine epithelium is a major site of the body's own oxytocin gene expression.

    In plain wordsIn rats at term, the lining of the womb makes a large amount of the body's own oxytocin.

    Peptide
    Oxytocin
    Outcome
    Not applicableUterine epithelium as site of OT gene expression at term
    Study

    ratn: not reported in source

    Rat uterus
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    By Northern blot analysis and in situ hybridization, we have determined that, at term, the rat uterine epithelium represents a major site of oxytocin (OT) gene expression.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In rats, uterine OT mRNA levels increased more than 150-fold during pregnancy.

    In plain wordsIn rats, the body's own oxytocin messenger RNA in the womb rose by more than 150 times during pregnancy.

    Peptide
    Oxytocin
    Outcome
    IncreaseUterine OT mRNA level during pregnancy
    Study

    ratn: not reported in source

    Rat uterus
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Measurements

    OT mRNA increase
    > 150 fold
    rat uterus, pregnancy

    Source sentences

    Summary
    OT mRNA levels increase > 150-fold during pregnancy

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In rats at term, uterine OT mRNA exceeded hypothalamic OT mRNA by a factor of 70.

    In plain wordsIn rats at term, the womb held about 70 times more of the body's own oxytocin messenger RNA than the hypothalamus.

    Peptide
    Oxytocin
    Outcome
    Not applicableUterine versus hypothalamic OT mRNA at term
    Study

    ratn: not reported in source

    Rat uterus
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Measurements

    Uterine to hypothalamic OT mRNA ratio
    70 factor
    rat, term

    Source sentences

    Summary
    at term, exceed hypothalamic OT mRNA by a factor of 70.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  4. 04AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In rat uterine epithelial cells, OT immunoreactivity was localized to transport vesicles in the apical compartment.

    In plain wordsIn rats, the body's own oxytocin was found in transport vesicles at the top of womb lining cells.

    Peptide
    Oxytocin
    Outcome
    Not applicableSubcellular location of OT immunoreactivity in uterine epithelium
    Study

    ratn: not reported in source

    Rat uterus
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    By cryoultramicroscopy, OT immunoreactivity was localized to transport vesicles in the apical compartment of uterine epithelial cells.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  5. 05AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In rats in vivo, estrogens strongly induced uterine OT gene expression.

    In plain wordsIn rats, the hormone estrogen strongly raised the womb's own oxytocin gene activity.

    Peptide
    Oxytocin
    Outcome
    IncreaseEstrogen effect on uterine OT gene expression
    Study

    ratn: not reported in source

    Rat uterus
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Estrogens (E) act as a strong inducer of uterine OT gene expression in vivo

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  6. 06AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In rats, the estrogen-induced rise in uterine OT gene expression was potentiated 7-fold by concomitant progesterone.

    In plain wordsIn rats, progesterone given with estrogen raised the womb's own oxytocin gene activity 7-fold more than estrogen alone.

    Peptide
    Oxytocin
    Outcome
    IncreaseProgesterone potentiation of estrogen-induced uterine OT gene expression
    Study

    ratn: not reported in source

    Rat uterus
    Comparator
    Estrogen alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Measurements

    Potentiation by progesterone
    7 fold
    rat uterus, with estrogen

    Source sentences

    Summary
    this effect is potentiated 7-fold by concomitant progesterone (P) administration.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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