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Study · Not a test of the peptide alone · 1995

3 results

Identification of agonist binding sites of vasopressin and oxytocin receptors.

Mouillac B, Chini B, Balestre MN, Jard S, Barberis C, Manning M, Tribollet E, Trumpp-Kallmeyer S, Hoflack J, Elands J

Advances in experimental medicine and biology1 Jan 1995Cited by 20 (Europe PMC)

PMID8713980 (opens in a new tab)PepBankPUB-08713980
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01LabNot a test of Oxytocin aloneOther designMechanism

    In a model of the rat V1a vasopressin receptor with mutagenesis results, the hormone was docked in a pocket buried in the transmembrane core of the receptor.

    In plain wordsIn lab and computer tests on a vasopressin receptor model, the hormone was placed in a pocket deep inside the receptor.

    Peptide
    Oxytocin
    Outcome
    Not applicableLocation of the hormone binding pocket in the receptor
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    The present model and experimental results led us to conclude that the hormone is docked in a pocket completely buried in the transmembrane core of the receptor.
    1 context sentence
    Summary · context
    Therefore, we have constructed a computer-generated 3 dimensional model of the rat V1a vasopressin receptor subtype which allowed us to propose residues likely to be involved in agonist binding.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02LabNot a test of Oxytocin aloneOther designMechanism

    Large polar residues, such as glutamine and lysine, in several transmembrane regions are involved in the binding of the neurohypophysial hormone.

    In plain wordsIn lab tests, certain large polar amino acids in the receptor were involved in binding the hormone.

    Peptide
    Oxytocin
    Outcome
    Not applicableResidues involved in neurohypophysial hormone binding
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    Large polar residues, such as glutamine and lysine, located in transmembrane regions 2,3,4 and 6 are involved in the binding of the neurohypophysial hormone.
    1 context sentence
    Summary · context
    Therefore, we have constructed a computer-generated 3 dimensional model of the rat V1a vasopressin receptor subtype which allowed us to propose residues likely to be involved in agonist binding.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  3. 03LabNot a test of Oxytocin aloneOther designMechanism

    The mutated residues are highly conserved in vasopressin and oxytocin receptors, which suggests that the agonist binding site is similar in all members of the receptor family.

    In plain wordsIn lab tests, the sites where the hormone binds looked similar across the vasopressin and oxytocin receptor family.

    Peptide
    Oxytocin
    Outcome
    Not applicableSimilarity of agonist binding sites across the receptor family
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Pharmacology

    Source sentences

    Summary
    Since all the mutated residues are highly conserved in AVP and OT receptors, we propose that the agonist binding site is similar in all members of the receptor family; only minor changes were found in antagonist potencies, suggesting that agonist and antagonist binding sites do not completely overlap.
    1 context sentence
    Summary · context
    Therefore, we have constructed a computer-generated 3 dimensional model of the rat V1a vasopressin receptor subtype which allowed us to propose residues likely to be involved in agonist binding.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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