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Study · Ex vivo tissue · rat · 1995

4 results

Oxytocin suppresses the GABAergic synaptic input in supraoptic neurones from the rat.

Brussaard AB

Advances in experimental medicine and biology1 Jan 1995Cited by 7 (Europe PMC)

PMID8713958 (opens in a new tab)PepBankPUB-08713958
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In rat supraoptic neurons, oxytocin strongly reduced the amplitude of GABAergic inhibitory synaptic currents in 73% of recordings.

    In plain wordsIn rat brain cells, oxytocin strongly reduced the inhibitory GABA signals in most recordings.

    Peptide
    Oxytocin
    Outcome
    DecreaseAmplitude of GABAergic IPSCs in SON neurons
    Study

    ratn: not reported in source

    Supraoptic nucleus slices, patch clamp
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Measurements

    Recordings with reduced IPSC amplitude
    73%
    SON neurons

    Source sentences

    Summary
    Application of oxytocin during such recordings, strongly reduced the amplitude of the IPSCs in 73% of the recordings.
    1 context sentence
    Summary · context
    In situ patch clamp recordings from individual neurons of the SON were performed.
  2. 02LabEx vivo tissueMechanism

    In rat supraoptic neurons, the oxytocin-induced reduction of inhibitory currents was completely reversed by washing.

    In plain wordsIn rat brain cells, the effect of oxytocin on inhibitory signals went away completely after washing.

    Peptide
    Oxytocin
    Outcome
    DecreaseReversibility of the oxytocin effect on IPSCs
    Study

    ratn: not reported in source

    Supraoptic nucleus slices, patch clamp
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    completely reversed by washing
    1 context sentence
    Summary · context
    In situ patch clamp recordings from individual neurons of the SON were performed.
  3. 03LabEx vivo tissueMechanism

    In rat supraoptic neurons, a specific oxytocin receptor antagonist blocked the oxytocin-induced reduction of inhibitory currents.

    In plain wordsIn rat brain cells, a drug that blocks oxytocin receptors stopped oxytocin from reducing inhibitory signals.

    Peptide
    Oxytocin
    Outcome
    DecreaseBlock of the oxytocin effect by an oxytocin receptor antagonist
    Study

    ratn: not reported in source

    Supraoptic nucleus slices, patch clamp
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    blocked by a specific oxytocin receptor antagonist
    1 context sentence
    Summary · context
    In situ patch clamp recordings from individual neurons of the SON were performed.
  4. 04LabEx vivo tissueMechanism

    In rat supraoptic neurons, the oxytocin-induced reduction of inhibitory currents was seen in slices from both female and male animals.

    In plain wordsIn rat brain slices, oxytocin reduced inhibitory signals in both females and males.

    Peptide
    Oxytocin
    Outcome
    DecreaseOxytocin effect on IPSCs in slices from female and male animals
    Study

    ratn: not reported in source

    Supraoptic nucleus slices, patch clamp
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    observed in slices from both female and from male animals
    1 context sentence
    Summary · context
    In situ patch clamp recordings from individual neurons of the SON were performed.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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