Oxytocin transgenic mice.

Murphy D, Ho MY

Advances in experimental medicine and biology1 Jan 1995Cited by 6 (Europe PMC)

PMID8713953PepBankPUB-08713953

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01AnimalEndogenous levelAnimal study (in vivo)Other
In mice, 7 days of salt-loading increased endogenous oxytocin RNA in the supraoptic nucleus.
In plain wordsIn mice, a week of salt-loading raised the body's own oxytocin RNA in a brain area called the supraoptic nucleus.
Peptide
Oxytocin
Outcome
IncreaseEndogenous OT RNA in the SON after salt-loading
Study
mousen: not reported in source
Transgenic mice
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
In parallel with the response of the endogenous murine OT RNA, 7 days of salt-loading resulted in a significant increase in the level of transgene RNA in the SON.
1 context sentence(design, population, supporting numbers)
Summary · context
We have compared the expression patterns in transgenic mice of bovine oxytocin constructs consisting of the 0.9 kilobase pair (kbp) structural gene flanked by varying lengths of upstream and downstream sequences.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0871395301
02AnimalEndogenous levelAnimal study (in vivo)Other
In mice, endogenous oxytocin RNA in the paraventricular nucleus did not respond significantly to salt-loading.
In plain wordsIn mice, salt-loading did not significantly change the body's own oxytocin RNA in the paraventricular nucleus.
Peptide
Oxytocin
Outcome
No significant changeEndogenous OT RNA in the PVN after salt-loading
Study
mousen: not reported in source
Transgenic mice
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
In the PVN, neither the endogenous OT RNA nor the transgene RNA responded significantly to salt-loading.
1 context sentence(design, population, supporting numbers)
Summary · context
We have compared the expression patterns in transgenic mice of bovine oxytocin constructs consisting of the 0.9 kilobase pair (kbp) structural gene flanked by varying lengths of upstream and downstream sequences.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0871395302

Studies that did not test the peptide alone6

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

03AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Other
In transgenic mice, 7 days of salt-loading significantly increased bovine oxytocin transgene RNA in the supraoptic nucleus.
In plain wordsIn mice carrying a bovine oxytocin gene, salt-loading raised the transgene RNA in the supraoptic nucleus.
Peptide
Oxytocin
Outcome
IncreaseTransgene RNA in the SON after salt-loading
Study
mousen: not reported in source
Transgenic mice
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
In parallel with the response of the endogenous murine OT RNA, 7 days of salt-loading resulted in a significant increase in the level of transgene RNA in the SON.
1 context sentence(design, population, supporting numbers)
Summary · context
We have compared the expression patterns in transgenic mice of bovine oxytocin constructs consisting of the 0.9 kilobase pair (kbp) structural gene flanked by varying lengths of upstream and downstream sequences.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0871395303
04AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Other
In transgenic mice, bovine oxytocin transgene RNA in the paraventricular nucleus did not respond significantly to salt-loading.
In plain wordsIn mice carrying a bovine oxytocin gene, salt-loading did not significantly change the transgene RNA in the paraventricular nucleus.
Peptide
Oxytocin
Outcome
No significant changeTransgene RNA in the PVN after salt-loading
Study
mousen: not reported in source
Transgenic mice
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
In the PVN, neither the endogenous OT RNA nor the transgene RNA responded significantly to salt-loading.
1 context sentence(design, population, supporting numbers)
Summary · context
We have compared the expression patterns in transgenic mice of bovine oxytocin constructs consisting of the 0.9 kilobase pair (kbp) structural gene flanked by varying lengths of upstream and downstream sequences.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0871395304
05AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In transgenic mice, the bOT3.5 oxytocin construct was expressed in the hypothalamus, unlike the bOT construct.
In plain wordsIn mice, one bovine oxytocin gene construct was active in the hypothalamus, but another was not.
Peptide
Oxytocin
Outcome
Not applicableHypothalamic expression of the bOT3.5 construct
Study
mousen: not reported in source
Transgenic mice
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
bOT3.5, which consists of 0.6 kbp of upstream sequences and 1.9 kbp of downstream sequences, retains testis and lung expression, but, surprisingly, is also expressed in the hypothalamus.
1 context sentence(design, population, supporting numbers)
Summary · context
We have compared the expression patterns in transgenic mice of bovine oxytocin constructs consisting of the 0.9 kilobase pair (kbp) structural gene flanked by varying lengths of upstream and downstream sequences.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0871395305
06AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Other
No transgenic founders were identified among over 200 offspring from eggs injected with construct bOT6.5.
In plain wordsIn mice, no offspring carried the bOT6.5 oxytocin gene construct, although over 200 offspring were born.
Peptide
Oxytocin
Outcome
Not applicableTransgenic founders with construct bOT6.5
Study
mousen: not reported in source
Transgenic mice
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
Over 200 offspring were derived from fertilized one-cell mouse eggs injected with construct bOT6.5, which consists of 3 kbp of upstream sequences and 2.6 kbp of downstream sequences. However, no transgenic founders were identified.
1 context sentence(design, population, supporting numbers)
Summary · context
We have compared the expression patterns in transgenic mice of bovine oxytocin constructs consisting of the 0.9 kilobase pair (kbp) structural gene flanked by varying lengths of upstream and downstream sequences.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0871395306
07AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Other
In transgenic mice, hypothalamic transgene RNA levels were elevated during late pregnancy and lactation.
In plain wordsIn mice carrying a bovine oxytocin gene, transgene RNA in the hypothalamus was higher in late pregnancy and lactation.
Peptide
Oxytocin
Outcome
IncreaseHypothalamic transgene RNA in late pregnancy and lactation
Study
mousen: not reported in source
Transgenic mice
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
Transgene RNA levels in the hypothalamus have also been shown to be elevated during late pregnancy and lactation.
1 context sentence(design, population, supporting numbers)
Summary · context
We have compared the expression patterns in transgenic mice of bovine oxytocin constructs consisting of the 0.9 kilobase pair (kbp) structural gene flanked by varying lengths of upstream and downstream sequences.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0871395307
08AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism
In transgenic mice, in situ hybridisation showed bOT3.5 expression in the supraoptic and paraventricular nuclei but not in the suprachiasmatic nucleus.
In plain wordsIn mice carrying a bovine oxytocin gene construct, the construct was active in two brain areas but not in a third.
Peptide
Oxytocin
Outcome
Not applicableHypothalamic distribution of bOT3.5 expression
Study
mousen: not reported in source
Transgenic mice
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
Within the hypothalamus, in situ hybridisation analysis has revealed expression of bOT3.5 in the supraoptic nucleus (SON) and paraventricular nucleus (PVN), but not in the suprachiasmatic nucleus (SCN).
1 context sentence(design, population, supporting numbers)
Summary · context
We have compared the expression patterns in transgenic mice of bovine oxytocin constructs consisting of the 0.9 kilobase pair (kbp) structural gene flanked by varying lengths of upstream and downstream sequences.
In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.
Report a problemFND-0871395308

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:53 UTC
First added · source update from Europe PMC

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