Immunotherapy with natural interleukins and/or thymosin alpha 1 potently augments T-lymphocyte responses of hydrocortisone-treated aged mice.

Hadden JW, Saha A, Sosa M, Hadden EM

International journal of immunopharmacology1 Oct 1995Cited by 25 (Europe PMC)

PMID8707447DOI10.1016/0192-0561(95)00069-ePepBankPUB-08707447

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In hydrocortisone-treated aged mice, thymosin alpha‑1 treatment augmented thymocyte and splenocyte in vitro responses to interleukins.
In plain wordsIn aged mice made immunodeficient, thymosin alpha‑1 raised the response of thymus and spleen cells to interleukins.
Peptide
Thymosin alpha-1
Outcome
IncreaseThymocyte and splenocyte in vitro response to interleukins
Study
mousen: not reported in source
Hydrocortisone-treated aged mice
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated · injection · five daily injectionsAs given in this study (mouse).
Source sentences
Summary
Both NCM and T alpha 1 in vivo treatment augmented thymocyte and splenocyte in vitro responses to both interleukins and mitogens.
1 context sentence(design, population, supporting numbers)
Summary · context
In an effort to determine the effectiveness of such agents in an immunotherapeutic strategy, we employed aged mice in a hydrocortisone treatment model to generate an immunodeficient state and to study its reconstitution.
Report a problemFND-0870744701
02AnimalAnimal study (in vivo)Efficacy outcome
In hydrocortisone-treated aged mice, thymosin alpha‑1 treatment augmented thymocyte and splenocyte in vitro responses to mitogens.
In plain wordsIn aged mice made immunodeficient, thymosin alpha‑1 raised the response of thymus and spleen cells to mitogens.
Peptide
Thymosin alpha-1
Outcome
IncreaseThymocyte and splenocyte in vitro response to mitogens
Study
mousen: not reported in source
Hydrocortisone-treated aged mice
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated · injection · five daily injectionsAs given in this study (mouse).
Source sentences
Summary
Both NCM and T alpha 1 in vivo treatment augmented thymocyte and splenocyte in vitro responses to both interleukins and mitogens.
1 context sentence(design, population, supporting numbers)
Summary · context
In an effort to determine the effectiveness of such agents in an immunotherapeutic strategy, we employed aged mice in a hydrocortisone treatment model to generate an immunodeficient state and to study its reconstitution.
Report a problemFND-0870744702
03AnimalAnimal study (in vivo)Efficacy outcome
In hydrocortisone-treated aged mice, thymosin alpha‑1 alone did not augment spleen weight.
In plain wordsIn aged mice made immunodeficient, thymosin alpha‑1 alone did not raise spleen weight.
Peptide
Thymosin alpha-1
Outcome
No significant changeSpleen weight
Study
mousen: not reported in source
Hydrocortisone-treated aged mice
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated · injection · five daily injectionsAs given in this study (mouse).
Source sentences
Summary
Of all the treatments, only NCM plus T alpha 1 augmented spleen weight; none augmented thymus weight.
1 context sentence(design, population, supporting numbers)
Summary · context
In an effort to determine the effectiveness of such agents in an immunotherapeutic strategy, we employed aged mice in a hydrocortisone treatment model to generate an immunodeficient state and to study its reconstitution.
Report a problemFND-0870744703
04AnimalAnimal study (in vivo)Efficacy outcome
In hydrocortisone-treated aged mice, thymosin alpha‑1 alone did not augment thymus weight.
In plain wordsIn aged mice made immunodeficient, thymosin alpha‑1 alone did not raise thymus weight.
Peptide
Thymosin alpha-1
Outcome
No significant changeThymus weight
Study
mousen: not reported in source
Hydrocortisone-treated aged mice
Outcome group
Immune response · Immune and inflammation
Studied dose
Dose not stated · injection · five daily injectionsAs given in this study (mouse).
Source sentences
Summary
Of all the treatments, only NCM plus T alpha 1 augmented spleen weight; none augmented thymus weight.
1 context sentence(design, population, supporting numbers)
Summary · context
In an effort to determine the effectiveness of such agents in an immunotherapeutic strategy, we employed aged mice in a hydrocortisone treatment model to generate an immunodeficient state and to study its reconstitution.
Report a problemFND-0870744704

Studies that did not test the peptide alone4

In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin alpha-1.

05AnimalNot a test of Thymosin alpha-1 aloneAnimal study (in vivo)Efficacy outcome
In hydrocortisone-treated aged mice, the combination of a natural cytokine mixture plus thymosin alpha‑1 augmented spleen weight.
In plain wordsIn aged mice made immunodeficient, a mix of natural cytokines plus thymosin alpha‑1 raised spleen weight.
Peptide
Thymosin alpha-1
Outcome
IncreaseSpleen weight with NCM plus T alpha 1
Study
mousen: not reported in source
Hydrocortisone-treated aged mice
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
Of all the treatments, only NCM plus T alpha 1 augmented spleen weight; none augmented thymus weight.
1 context sentence(design, population, supporting numbers)
Summary · context
In an effort to determine the effectiveness of such agents in an immunotherapeutic strategy, we employed aged mice in a hydrocortisone treatment model to generate an immunodeficient state and to study its reconstitution.
In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.
Report a problemFND-0870744705
06AnimalNot a test of Thymosin alpha-1 aloneAnimal study (in vivo)Efficacy outcome
In hydrocortisone-treated aged mice, a natural cytokine mixture plus thymosin alpha‑1 significantly increased spleen CD4 positive T-cell numbers.
In plain wordsIn aged mice made immunodeficient, a mix of natural cytokines plus thymosin alpha‑1 raised spleen CD4 T-cell numbers.
Peptide
Thymosin alpha-1
Outcome
IncreaseSpleen CD4 T-cell numbers with NCM plus T alpha 1
Study
mousen: not reported in source
Hydrocortisone-treated aged mice
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
Surface marker analyses of T-lymphocytes and subsets indicate that treatment of mice with NCM plus T alpha 1 increased spleen T-cell numbers of both CD4 and CD8 positive cells significantly.
1 context sentence(design, population, supporting numbers)
Summary · context
In an effort to determine the effectiveness of such agents in an immunotherapeutic strategy, we employed aged mice in a hydrocortisone treatment model to generate an immunodeficient state and to study its reconstitution.
In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.
Report a problemFND-0870744706
07AnimalNot a test of Thymosin alpha-1 aloneAnimal study (in vivo)Efficacy outcome
In hydrocortisone-treated aged mice, a natural cytokine mixture plus thymosin alpha‑1 significantly increased spleen CD8 positive T-cell numbers.
In plain wordsIn aged mice made immunodeficient, a mix of natural cytokines plus thymosin alpha‑1 raised spleen CD8 T-cell numbers.
Peptide
Thymosin alpha-1
Outcome
IncreaseSpleen CD8 T-cell numbers with NCM plus T alpha 1
Study
mousen: not reported in source
Hydrocortisone-treated aged mice
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
Surface marker analyses of T-lymphocytes and subsets indicate that treatment of mice with NCM plus T alpha 1 increased spleen T-cell numbers of both CD4 and CD8 positive cells significantly.
1 context sentence(design, population, supporting numbers)
Summary · context
In an effort to determine the effectiveness of such agents in an immunotherapeutic strategy, we employed aged mice in a hydrocortisone treatment model to generate an immunodeficient state and to study its reconstitution.
In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.
Report a problemFND-0870744707
08AnimalNot a test of Thymosin alpha-1 aloneAnimal study (in vivo)Efficacy outcome
In hydrocortisone-treated aged mice, a natural cytokine mixture plus thymosin alpha‑1 did not augment thymus weight.
In plain wordsIn aged mice made immunodeficient, a mix of natural cytokines plus thymosin alpha‑1 did not raise thymus weight.
Peptide
Thymosin alpha-1
Outcome
No significant changeThymus weight with NCM plus T alpha 1
Study
mousen: not reported in source
Hydrocortisone-treated aged mice
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
Of all the treatments, only NCM plus T alpha 1 augmented spleen weight; none augmented thymus weight.
In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.
Report a problemFND-0870744708

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
10 Oct 2026, 08:55 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 03:02 UTC
First added · source update from Europe PMC

Subjects

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