In rats under hypokinetic stress, a single intraperitoneal injection of delta sleep-inducing peptide prevented the development of spontaneous epileptic activity.
In plain wordsIn rats under stress, one injection of delta sleep-inducing peptide prevented spontaneous epileptic activity.
- Outcome
- DecreaseSpontaneous epileptic activity under hypokinetic stress
- Study
ratn: not reported in source
- Outcome group
- Neuroprotection · Nervous system and cognition
- Studied dose
- 12 microns/100 g body weigh · intraperitoneal · single injectionAs given in this study (rat).
Source sentences
It was found, that a single intraperitoneal DSIP injection (12 microns/100 g body weigh, 1 h before placing the animals into the stress condition) prevented spontaneous epileptic activity development due to creation of optimal ratio between monoamines in brain structures.
1 context sentence(design, population, supporting numbers)
The DSIP influence on the rat cortex, thalamic and hypothalamic adrenaline, noradrenaline, DOPA, dopamine and serotonin level under normal, hypokinetic stress condition (1 h in duration) and experimental audiogenic epilepsy was studied.