[The characteristics of the anxiolytic action of taftsin and its analog TP-7 on behavior and serotonin metabolism in the brain of rats with chronic deprivation of serotoninergic system activity].

Seredenin SB, Semenova TP, Kozlovskaia MM, Medvinskaia NI, Nezovibat'ko VN

Eksperimental'naia i klinicheskaia farmakologiia1 Nov 1995

PMID8704608PepBankPUB-08704608

Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with chronic serotonergic deprivation, intracutaneous TP-7 (Selank) weakened the perception of stress situations, as did taftcine.
In plain wordsIn rats with low brain serotonin, Selank weakened the perception of stress. Taftcine did the same.
Peptide
Selank
Outcome
DecreasePerception of stress situations
Study
ratn = 95
rats with chronic deprivation of serotonergic activity (neonatal 5,7-dihydroxytriptamine)
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
300 micrograms/kg · intracutaneousAs given in this study (rat).
Source sentences
Summary
weakening perception of stress situations
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of taftcine (Thr-Lys-Pro-Arg) and its analog TP-7 (Thr-Lys-Pro-Arg-Pro-Gly-Pro) on rat behavior and serotonin brain exchange was studied in 95 adult male Wistar rats neonatally administered with 5,7-dihydroxytriptamine.
Report a problemFND-0870460801
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with chronic serotonergic deprivation, TP-7 (Selank) increased the stability of investigation behavior, as did taftcine.
In plain wordsIn rats with low brain serotonin, Selank made exploring behaviour more stable. Taftcine did the same.
Peptide
Selank
Outcome
IncreaseStability of investigation behavior
Study
ratn = 95
rats with chronic deprivation of serotonergic activity (neonatal 5,7-dihydroxytriptamine)
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
300 micrograms/kg · intracutaneousAs given in this study (rat).
Source sentences
Summary
an increase in stability of investigation behavior
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of taftcine (Thr-Lys-Pro-Arg) and its analog TP-7 (Thr-Lys-Pro-Arg-Pro-Gly-Pro) on rat behavior and serotonin brain exchange was studied in 95 adult male Wistar rats neonatally administered with 5,7-dihydroxytriptamine.
Report a problemFND-0870460802
03AnimalAnimal study (in vivo)Mechanism
In rats with chronic serotonergic deprivation, TP-7 (Selank) normalized the serotonin level in the brain, as did taftcine.
In plain wordsIn rats with low brain serotonin, Selank brought brain serotonin back to normal. Taftcine did the same.
Peptide
Selank
Outcome
Direction not reportedBrain serotonin level
Study
ratn = 95
rats with chronic deprivation of serotonergic activity (neonatal 5,7-dihydroxytriptamine)
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
300 micrograms/kg · intracutaneousAs given in this study (rat).
Source sentences
Summary
normalization of serotonin level in the brain
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of taftcine (Thr-Lys-Pro-Arg) and its analog TP-7 (Thr-Lys-Pro-Arg-Pro-Gly-Pro) on rat behavior and serotonin brain exchange was studied in 95 adult male Wistar rats neonatally administered with 5,7-dihydroxytriptamine.
Report a problemFND-0870460803
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with chronic serotonergic deprivation, the anxiolytic activity of TP-7 (Selank) was more pronounced than that of taftcine.
In plain wordsIn rats with low brain serotonin, Selank reduced anxiety more strongly than taftcine.
Peptide
Selank
Outcome
IncreaseAnxiolytic activity compared with taftcine
Study
ratn = 95
rats with chronic deprivation of serotonergic activity (neonatal 5,7-dihydroxytriptamine)
Comparator
Taftcine
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
Dose not stated
Source sentences
Summary
Anxiolytic and psychostimulant activities of TP-7 are more pronounced than those of tafcine.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of taftcine (Thr-Lys-Pro-Arg) and its analog TP-7 (Thr-Lys-Pro-Arg-Pro-Gly-Pro) on rat behavior and serotonin brain exchange was studied in 95 adult male Wistar rats neonatally administered with 5,7-dihydroxytriptamine.
Report a problemFND-0870460804
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with chronic serotonergic deprivation, the psychostimulant activity of TP-7 (Selank) was more pronounced than that of taftcine.
In plain wordsIn rats with low brain serotonin, Selank had a stronger stimulating effect than taftcine.
Peptide
Selank
Outcome
IncreasePsychostimulant activity compared with taftcine
Study
ratn = 95
rats with chronic deprivation of serotonergic activity (neonatal 5,7-dihydroxytriptamine)
Comparator
Taftcine
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
Dose not stated
Source sentences
Summary
Anxiolytic and psychostimulant activities of TP-7 are more pronounced than those of tafcine.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of taftcine (Thr-Lys-Pro-Arg) and its analog TP-7 (Thr-Lys-Pro-Arg-Pro-Gly-Pro) on rat behavior and serotonin brain exchange was studied in 95 adult male Wistar rats neonatally administered with 5,7-dihydroxytriptamine.
Report a problemFND-0870460805

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 17:28 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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