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Study · In vitro (cells) · rat · 1996

4 results

Transcriptional and post-translational regulation of insulin-like growth factor-binding protein-5 in rat articular chondrocytes.

Matsumoto T, Gargosky SE, Oh Y, Rosenfeld RG

The Journal of endocrinology1 Feb 1996Cited by 18 (Europe PMC)

PMID8699150 (opens in a new tab)DOI10.1677/joe.0.1480355 (opens in a new tab)PepBankPUB-08699150
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In rat articular chondrocytes, Des(1‑3) IGF-I induced IGFBP-5 peptide.

    In plain wordsIn cells from rat cartilage, Des(1‑3) IGF-I increased IGFBP-5 peptide.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseIGFBP-5 peptide induction
    Study

    ratn: not reported in source

    Primary articular chondrocytes
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Des(1-3) IGF-I and [Gln6, Ala7, Tyr18, Leu19] IGF-II ([QAYL] IGF-II), which bind to the type 1 IGF receptor but not to IGFBPs, also induced IGFBP-5 peptide, although the increase was less than with IGF-I or IGF-II treatment of RAC.
    1 context sentence
    Summary · context
    The aim of this study was to assess the regulation of insulin-like growth factor-binding proteins (IGFBPs) by IGFs in primary cultures of rat articular chondrocytes (RAC).
  2. 02LabIn vitro (cells)Mechanism

    In rat articular chondrocytes, Des(1‑3) IGF-I induced less IGFBP-5 peptide than IGF-I.

    In plain wordsIn cells from rat cartilage, Des(1‑3) IGF-I increased IGFBP-5 peptide less than IGF-I.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    DecreaseIGFBP-5 peptide induction versus IGF-I
    Study

    ratn: not reported in source

    Primary articular chondrocytes
    Comparator
    IGF-I
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Des(1-3) IGF-I and [Gln6, Ala7, Tyr18, Leu19] IGF-II ([QAYL] IGF-II), which bind to the type 1 IGF receptor but not to IGFBPs, also induced IGFBP-5 peptide, although the increase was less than with IGF-I or IGF-II treatment of RAC.
    1 context sentence
    Summary · context
    The aim of this study was to assess the regulation of insulin-like growth factor-binding proteins (IGFBPs) by IGFs in primary cultures of rat articular chondrocytes (RAC).
  3. 03LabIn vitro (cells)Mechanism

    In rat articular chondrocytes, Des(1‑3) IGF-I induced less IGFBP-5 peptide than IGF-II.

    In plain wordsIn cells from rat cartilage, Des(1‑3) IGF-I increased IGFBP-5 peptide less than IGF-II.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    DecreaseIGFBP-5 peptide induction versus IGF-II
    Study

    ratn: not reported in source

    Primary articular chondrocytes
    Comparator
    IGF-II
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Des(1-3) IGF-I and [Gln6, Ala7, Tyr18, Leu19] IGF-II ([QAYL] IGF-II), which bind to the type 1 IGF receptor but not to IGFBPs, also induced IGFBP-5 peptide, although the increase was less than with IGF-I or IGF-II treatment of RAC.
    1 context sentence
    Summary · context
    The aim of this study was to assess the regulation of insulin-like growth factor-binding proteins (IGFBPs) by IGFs in primary cultures of rat articular chondrocytes (RAC).
  4. 04LabIn vitro (cells)Mechanism

    In rat articular chondrocytes, des(1‑3) IGF-I increased steady-state IGFBP-5 mRNA levels.

    In plain wordsIn cells from rat cartilage, des(1‑3) IGF-I increased IGFBP-5 mRNA levels.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseIGFBP-5 mRNA
    Study

    ratn: not reported in source

    Primary articular chondrocytes
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Northern blotting analysis showed that IGF-I, IGF-II and des(1-3) IGF-I treatment of RAC increased steady state levels of IGFBP-5 mRNA, suggesting that the IGF-mediated increase in IGFBP-5 is transcriptionally modulated.
    1 context sentence
    Summary · context
    The aim of this study was to assess the regulation of insulin-like growth factor-binding proteins (IGFBPs) by IGFs in primary cultures of rat articular chondrocytes (RAC).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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