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Study · In vitro (cells) · 1996

4 results

The role of IGFBP-3 in the regulation of IGFBP-4 proteolysis.

Donnelly MJ, Holly JM

The Journal of endocrinology1 Jun 1996Cited by 17 (Europe PMC)

PMID8691093 (opens in a new tab)DOI10.1677/joe.0.149r001 (opens in a new tab)PepBankPUB-08691093
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In cultured human dermal fibroblasts, IGF-I and its analogs (LR3 and Des[1-3]) induced a dose-dependent increase in proliferation.

    In plain wordsIn lab-grown human skin cells, IGF-I and its analogs, including LR3, increased cell growth in a dose-related way.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseFibroblast proliferation
    Study

    humann: not reported in source

    cultured human dermal fibroblasts
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    IGF-I and the analogs of IGF-I (LR3 and Des[1-3]) induced a dose dependent increase in both proliferation and IGFBP-3 production.
    1 context sentence
    Summary · context
    In the current study we have examined the regulation of IGFBP-4 protease produced by cultured human dermal fibroblasts.
  2. 02LabIn vitro (cells)Mechanism

    In cultured human dermal fibroblasts, IGF-I and its analogs (LR3 and Des[1-3]) induced a dose-dependent increase in IGFBP-3 production.

    In plain wordsIn lab-grown human skin cells, IGF-I and its analogs, including LR3, increased IGFBP-3 production in a dose-related way.

    Peptide
    IGF-1 LR3
    Outcome
    IncreaseIGFBP-3 production
    Study

    humann: not reported in source

    cultured human dermal fibroblasts
    Outcome group
    Receptor activity and mechanism · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    IGF-I and the analogs of IGF-I (LR3 and Des[1-3]) induced a dose dependent increase in both proliferation and IGFBP-3 production.
    1 context sentence
    Summary · context
    In the current study we have examined the regulation of IGFBP-4 protease produced by cultured human dermal fibroblasts.
  3. 03LabIn vitro (cells)Mechanism

    In cultured human dermal fibroblasts, IGFBP-4 proteolysis was not observed when cells were exposed to LR3, unlike Des[1-3].

    In plain wordsIn lab-grown human skin cells, LR3 did not cause IGFBP-4 breakdown, unlike Des[1-3].

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeIGFBP-4 proteolysis in cells exposed to LR3
    Study

    humann: not reported in source

    cultured human dermal fibroblasts
    Outcome group
    Receptor activity and mechanism · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    IGFBP-4 proteolysis was observed when cells were exposed to Des[1-3] (albeit at higher concentrations) but not with LR3.
    1 context sentence
    Summary · context
    In the current study we have examined the regulation of IGFBP-4 protease produced by cultured human dermal fibroblasts.
  4. 04LabIn vitro (cells)Mechanism

    In media from unexposed fibroblasts, LR3 did not induce IGFBP-4 proteolysis, unlike IGF-I.

    In plain wordsIn lab tests with media from skin cells, LR3 did not cause IGFBP-4 breakdown, unlike IGF-I.

    Peptide
    IGF-1 LR3
    Outcome
    No significant changeIGFBP-4 proteolysis in media from unexposed cells
    Study

    humann: not reported in source

    cultured human dermal fibroblasts
    Outcome group
    Receptor activity and mechanism · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Addition of IGF-I to media from cells unexposed to IGF induced IGFBP-4 proteolysis but this was not seen with LR3 which does not bind to IGFBP-3.
    1 context sentence
    Summary · context
    In the current study we have examined the regulation of IGFBP-4 protease produced by cultured human dermal fibroblasts.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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