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Study · Not a test of the peptide alone · 1993

3 results

Gonadal steroids have paradoxical effects on brain oxytocin receptors.

Insel TR, Young L, Witt DM, Crews D

Journal of neuroendocrinology1 Dec 1993Cited by 68 (Europe PMC)

PMID8680433 (opens in a new tab)DOI10.1111/j.1365-2826.1993.tb00531.x (opens in a new tab)PepBankPUB-08680433
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In male mice, the distribution of oxytocin receptors in the forebrain differed markedly from the pattern previously described in the rat, irrespective of steroid treatment.

    In plain wordsIn mice, oxytocin receptors sat in different forebrain places than previously described in rats.

    Peptide
    Oxytocin
    Outcome
    Not applicableOxytocin receptor distribution in mouse versus rat forebrain
    Study

    mousen: not reported in source

    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Irrespective of steroid treatment, the distribution of oxytocin receptors in mouse forebrain differed markedly from patterns previously described in the rat.
    1 context sentence
    Summary · context
    Three groups of male mice were compared: castrates treated with blank capsules, castrates treated with testosterone filled capsules, and intact males.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In male mice, oxytocin receptor binding in the ventromedial hypothalamus was about double in untreated castrates compared with intact males or testosterone-treated castrates.

    In plain wordsIn male mice, untreated castrates had about double the oxytocin receptor binding in one hypothalamic area compared with intact or testosterone-treated males.

    Peptide
    Oxytocin
    Outcome
    IncreaseOxytocin receptor binding in ventromedial hypothalamus
    Study

    mousen: not reported in source

    Comparator
    Intact males and testosterone-treated castrates
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    In the mouse ventromedial nucleus of the hypothalamus, binding in the untreated castrate males was approximately double that observed in either the intact or the testosterone-treated castrates.
    1 context sentence
    Summary · context
    Three groups of male mice were compared: castrates treated with blank capsules, castrates treated with testosterone filled capsules, and intact males.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  3. 03AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Mechanism

    In male mice, testosterone treatment increased oxytocin receptor binding in the intermediate zone of the lateral septum.

    In plain wordsIn male mice, testosterone treatment increased oxytocin receptor binding in one part of the lateral septum.

    Peptide
    Oxytocin
    Outcome
    IncreaseOxytocin receptor binding in lateral septum
    Study

    mousen: not reported in source

    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    In other regions of the mouse brain, such as the intermediate zone of the lateral septum, binding to oxytocin receptors was increased with testosterone treatment.
    1 context sentence
    Summary · context
    Three groups of male mice were compared: castrates treated with blank capsules, castrates treated with testosterone filled capsules, and intact males.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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