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Study · Animal study (in vivo) · rat · 1995

1 result

Prolyl-leucyl-glycinamide, thyrotropin-releasing hormone and beta-endorphin-(10-16), like antidepressants, antagonize melatonin-induced behavioural changes in rats.

Hatta K, Wolterink G, Van Ree JM

European journal of pharmacology1 Sept 1995Cited by 6 (Europe PMC)

PMID8666016 (opens in a new tab)DOI10.1016/0014-2999(95)00473-x (opens in a new tab)PepBankPUB-08666016
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, PLG counteracted melatonin-induced behavioral changes as effectively as beta-endorphin-(10-16).

    In plain wordsIn rats, PLG counteracted melatonin-induced behavior changes as effectively as beta-endorphin-(10-16).

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    No significant changeMelatonin-induced behavioral changes
    Study

    ratn: not reported in source

    Melatonin injection into nucleus accumbens
    Comparator
    beta-endorphin-(10-16)
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    Dose not stated · subcutaneousAs given in this study (rat).

    Source sentences

    Summary
    PLG and TRH were found to be as effective as beta-endorphin-(10-16) in counteracting the melatonin-induced behavioural changes.
    1 context sentence
    Summary · context
    In the present study the influence of subcutaneously administered prolyl-leucyl-glycinamide (PLG) and thyrotropin-releasing hormone (TRH) on the behavioural changes induced by melatonin administration in the nucleus accumbens were investigated and compared with that of beta-endorphin-(10-16).

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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