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Study · Animal study (in vivo) · mouse · 1996

8 results

Effects of a nonapeptide thymic hormone on intestinal intraepithelial lymphocytes in mice following administration of 5-fluorouracil.

Inagaki-Ohara K, Kobayashi N, Nishimura H, Sakai T, Matsumoto Y, Hiromatsu K, Awaya A, Yoshikai Y

Cellular immunology1 Jul 1996Cited by 17 (Europe PMC)

PMID8660834 (opens in a new tab)DOI10.1006/cimm.1996.0169 (opens in a new tab)PepBankPUB-08660834
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice after 5-FU administration, FTS significantly accelerated recovery of intestinal intraepithelial lymphocyte numbers.

    In plain wordsIn mice after 5-FU treatment, FTS accelerated recovery of intestinal immune cell numbers.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseIntestinal intraepithelial lymphocyte recovery
    Study

    mousen: not reported in source

    5-FU-treated mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    FTS treatment significantly accelerated the recovery in cell number of i-IELs after administration of 5-FU.
    1 context sentence
    Summary · context
    In this study, we investigated the effects of FTS on the kinetics of i-IELs in mice following a single administration of 5-fluorouracil (5-FU).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice after 5-FU administration, FTS-associated recovery mainly reflected a rapid increase in CD8 alpha alpha+ intraepithelial lymphocytes.

    In plain wordsIn mice after 5-FU treatment, FTS accelerated recovery mainly through an increase in CD8 alpha alpha+ intestinal immune cells.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseCD8 alpha alpha+ intraepithelial lymphocytes
    Study

    mousen: not reported in source

    5-FU-treated mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Flow cytometric analysis revealed that this accelerated recovery was mainly due to a rapid increase in CD8 alpha alpha+ i-IELs.
    2 context sentences
    Summary · context
    FTS treatment significantly accelerated the recovery in cell number of i-IELs after administration of 5-FU.
    Summary · context
    In this study, we investigated the effects of FTS on the kinetics of i-IELs in mice following a single administration of 5-fluorouracil (5-FU).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In adult thymectomized mice after 5-FU administration, FTS caused rapid recovery of CD8 alpha alpha+ intraepithelial lymphocytes.

    In plain wordsIn mice without a functional thymus, FTS accelerated recovery of CD8 alpha alpha+ intestinal immune cells after 5-FU.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseCD8 alpha alpha+ lymphocyte recovery after thymectomy
    Study

    mousen: not reported in source

    adult thymectomized mice after 5-FU
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Similar findings were also evident in adult thymectomized (ATX) mice, indicating that FTS treatment caused a rapid recovery of CD8 alpha alpha+ i-IELs following 5-FU administration in the absence of a functional thymus.
    1 context sentence
    Summary · context
    In this study, we investigated the effects of FTS on the kinetics of i-IELs in mice following a single administration of 5-fluorouracil (5-FU).
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice after 5-FU administration, FTS augmented interleukin-2 mRNA expression in intestinal intraepithelial lymphocytes.

    In plain wordsIn mice after 5-FU treatment, FTS increased interleukin-2 gene activity in intestinal immune cells.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseInterleukin-2 mRNA expression
    Study

    mousen: not reported in source

    5-FU-treated mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, expression levels of the mRNAs for interleukin-2, interferon-gamma, and transforming growth factor beta 1 in the i-IELs were augmented by FTS treatment.
    1 context sentence
    Summary · context
    In this study, we investigated the effects of FTS on the kinetics of i-IELs in mice following a single administration of 5-fluorouracil (5-FU).
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice after 5-FU administration, FTS augmented interferon-gamma mRNA expression in intestinal intraepithelial lymphocytes.

    In plain wordsIn mice after 5-FU treatment, FTS increased interferon-gamma gene activity in intestinal immune cells.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseInterferon-gamma mRNA expression
    Study

    mousen: not reported in source

    5-FU-treated mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, expression levels of the mRNAs for interleukin-2, interferon-gamma, and transforming growth factor beta 1 in the i-IELs were augmented by FTS treatment.
    1 context sentence
    Summary · context
    In this study, we investigated the effects of FTS on the kinetics of i-IELs in mice following a single administration of 5-fluorouracil (5-FU).
  6. 06AnimalAnimal study (in vivo)Mechanism

    In mice after 5-FU administration, FTS augmented transforming growth factor beta 1 mRNA expression in intestinal intraepithelial lymphocytes.

    In plain wordsIn mice after 5-FU treatment, FTS increased transforming growth factor beta 1 gene activity in intestinal immune cells.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseTransforming growth factor beta 1 mRNA expression
    Study

    mousen: not reported in source

    5-FU-treated mice
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, expression levels of the mRNAs for interleukin-2, interferon-gamma, and transforming growth factor beta 1 in the i-IELs were augmented by FTS treatment.
    1 context sentence
    Summary · context
    In this study, we investigated the effects of FTS on the kinetics of i-IELs in mice following a single administration of 5-fluorouracil (5-FU).
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In mice, FTS protected against 5-FU-induced lethal toxicity.

    In plain wordsIn mice, FTS protected against lethal toxicity from 5-FU.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    Decrease5-FU-induced lethal toxicity
    Study

    mousen: not reported in source

    5-FU-treated mice
    Outcome group
    Mortality · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    FTS treatment protected mice from 5-FU-induced lethal toxicity, accompanied with an inhibition of the translocation of Enterobacteriaceae.
    1 context sentence
    Summary · context
    In this study, we investigated the effects of FTS on the kinetics of i-IELs in mice following a single administration of 5-fluorouracil (5-FU).
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In mice after 5-FU administration, FTS inhibited Enterobacteriaceae translocation.

    In plain wordsIn mice after 5-FU treatment, FTS reduced movement of Enterobacteriaceae from the intestine.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseEnterobacteriaceae translocation
    Study

    mousen: not reported in source

    5-FU-treated mice
    Outcome group
    Infection and antimicrobial activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Notably, FTS treatment protected mice from 5-FU-induced lethal toxicity, accompanied with an inhibition of the translocation of Enterobacteriaceae.
    1 context sentence
    Summary · context
    In this study, we investigated the effects of FTS on the kinetics of i-IELs in mice following a single administration of 5-fluorouracil (5-FU).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

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