Inhibition of cellular proliferation and modulation of insulin-like growth factor binding proteins by retinoids in a bovine mammary epithelial cell line.

Woodward TL, Turner JD, Hung HT, Zhao X

Journal of cellular physiology1 Jun 1996Cited by 28 (Europe PMC)

PMID8655603DOI10.1002/(sici)1097-4652(199606)167:3<488::aid-jcp13>3.0.co;2-0PepBankPUB-08655603

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

2 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Mechanism
In bovine mammary cells, des(1‑3) IGF-I treatment produced detectable IGFBP-3 in conditioned medium.
In plain wordsIn cells, des(1‑3) IGF-I treatment produced detectable IGFBP-3 in the culture medium.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
IncreaseIGFBP-3 in conditioned medium
Study
bovinen: not reported in source
MAC-T mammary epithelial cells
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
Treatment with insulin or des(1-3) IGF-I resulted in the appearance of IGFBP-3 in conditioned media and on the cell surface.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we have characterized the inhibition of MAC-T (a nontransformed bovine mammary epithelial cell line) cellular proliferation by retinoids and their role in regulating insulin-like growth factor binding proteins (IGFBPs).
Report a problemFND-0865560302
02LabIn vitro (cells)Mechanism
In bovine mammary cells, des(1‑3) IGF-I treatment produced detectable IGFBP-3 on the cell surface.
In plain wordsIn cells, des(1‑3) IGF-I treatment produced detectable IGFBP-3 on the cell surface.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
IncreaseCell-surface IGFBP-3
Study
bovinen: not reported in source
MAC-T mammary epithelial cells
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
Treatment with insulin or des(1-3) IGF-I resulted in the appearance of IGFBP-3 in conditioned media and on the cell surface.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we have characterized the inhibition of MAC-T (a nontransformed bovine mammary epithelial cell line) cellular proliferation by retinoids and their role in regulating insulin-like growth factor binding proteins (IGFBPs).
Report a problemFND-0865560303

Studies that did not test the peptide alone3

In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking IGF-1 DES (des(1-3)IGF-I).

03LabNot a test of IGF-1 DES (des(1-3)IGF-I) aloneIn vitro (cells)Activity measurement
In bovine mammary cells, retinoic acid inhibited thymidine incorporation less effectively under des(1‑3) IGF-I stimulation than under IGF-I or serum stimulation.
In plain wordsIn cells, retinoic acid inhibited thymidine incorporation less with des(1‑3) IGF-I stimulation than with IGF-I or serum stimulation.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
DecreaseRetinoic acid inhibition of thymidine incorporation
Study
bovinen: not reported in source
MAC-T mammary epithelial cells
Comparator
IGF-I- or serum-stimulated cells
Outcome group
Receptor activity and mechanism · Pharmacology
Source sentences
Summary
Retinoic acid was less effective in inhibiting thymidine incorporation when cells were stimulated with insulin, des(1-3) IGF-I, or Long(R3) IGF-I when compared to cells stimulated with native IGF-I or serum.
1 context sentence(design, population, supporting numbers)
Summary · context
Here, we have characterized the inhibition of MAC-T (a nontransformed bovine mammary epithelial cell line) cellular proliferation by retinoids and their role in regulating insulin-like growth factor binding proteins (IGFBPs).
In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).
Report a problemFND-0865560301
04LabNot a test of IGF-1 DES (des(1-3)IGF-I) aloneIn vitro (cells)Mechanism
In bovine mammary cells treated with insulin or des(1‑3) IGF-I, retinoic acid reduced IGFBP-3 in conditioned medium.
In plain wordsIn cells treated with insulin or des(1‑3) IGF-I, retinoic acid reduced IGFBP-3 in the culture medium.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
DecreaseRetinoic acid reduction of medium IGFBP-3
Study
bovinen: not reported in source
MAC-T mammary epithelial cells
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
However, RA significantly reduced IGFBP-3 levels in conditioned media and eliminated IGFBP-3 associated with the plasma membrane.
2 context sentences(design, population, supporting numbers)
Summary · context
Treatment with insulin or des(1-3) IGF-I resulted in the appearance of IGFBP-3 in conditioned media and on the cell surface.
Summary · context
Here, we have characterized the inhibition of MAC-T (a nontransformed bovine mammary epithelial cell line) cellular proliferation by retinoids and their role in regulating insulin-like growth factor binding proteins (IGFBPs).
In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).
Report a problemFND-0865560304
05LabNot a test of IGF-1 DES (des(1-3)IGF-I) aloneIn vitro (cells)Mechanism
In bovine mammary cells treated with insulin or des(1‑3) IGF-I, retinoic acid eliminated membrane-associated IGFBP-3.
In plain wordsIn cells treated with insulin or des(1‑3) IGF-I, retinoic acid eliminated membrane-associated IGFBP-3.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
DecreaseRetinoic acid removal of membrane IGFBP-3
Study
bovinen: not reported in source
MAC-T mammary epithelial cells
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Source sentences
Summary
However, RA significantly reduced IGFBP-3 levels in conditioned media and eliminated IGFBP-3 associated with the plasma membrane.
2 context sentences(design, population, supporting numbers)
Summary · context
Treatment with insulin or des(1-3) IGF-I resulted in the appearance of IGFBP-3 in conditioned media and on the cell surface.
Summary · context
Here, we have characterized the inhibition of MAC-T (a nontransformed bovine mammary epithelial cell line) cellular proliferation by retinoids and their role in regulating insulin-like growth factor binding proteins (IGFBPs).
In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).
Report a problemFND-0865560305

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 4Current
21 Oct 2026, 15:58 UTC
Study results updated
Versions 2 to 3
21 Oct 2026, 13:52 UTC
The same notice was added 2 times, first on 21 Oct 2026, 12:50 UTC. The status did not change between them.
Study data updated · source update from Europe PMC
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Inhibition of cellular proliferation and modulation of insulin-like growth factor binding proteins by retinoids in a bovine mammary epithelial cell line.

Summary

Results from this study5

Studies that did not test the peptide alone3

Version history

Subjects

Publication types

MeSH terms