Exogenous oxytocin decreases interestrous interval of cyclic gilts.

Prince BC, Mirando MA, Becker WC, Hostetler CE

Journal of animal science1 Dec 1995Cited by 5 (Europe PMC)

PMID8655444DOI10.2527/1995.73123681xPepBankPUB-08655444

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In cyclic gilts, intravenous oxytocin injections once per day shortened the interestrous interval to 19.9 d versus 20.8 d with vehicle.
In plain wordsIn female pigs, oxytocin injected into a vein once a day shortened the time between heats compared with vehicle.
Peptide
Oxytocin
Outcome
DecreaseInterestrous interval, Exp. 1 (i.v. injections once per day)
Study
pign: not reported in source
Cyclic gilts
Comparator
Vehicle or control injections
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
20 USP units (20 IU), once per day · intravenous · d 10, 12, 14 and 16 after estrusAs given in this study (pig).
Measurements
Interestrous interval, oxytocin
19.9 d
Exp. 1
Interestrous interval, control
20.8 d
Exp. 1
Source sentences
Summary
i.v. injections of 20 USP units (equivalent to 20 IU) of OT, once/day via an ear vein on d 10, 12, 14, and 16 after estrus, decreased (P < .01) interestrous interval (19.9 +/- .2 d) compared with vehicle-injected control gilts (20.8 +/- .2 d)
1 context sentence(design, population, supporting numbers)
Summary · context
Oxytocin (OT) stimulates pulsatile secretion of uterine PGF2 alpha in ruminants, but the role of OT in regulation of the estrous cycle of pigs is not clear. four experiments were performed to examine the effect of exogenous OT on interestrous interval of intact cyclic and hysterectomized gilts.
Report a problemFND-0865544401
02AnimalAnimal study (in vivo)Efficacy outcome
In cyclic gilts, intravenous oxytocin did not change the ovulation rate at the next estrus (12.1 versus 12.0 corpora lutea).
In plain wordsIn female pigs, oxytocin into a vein did not change how many eggs were released at the next heat compared with vehicle.
Peptide
Oxytocin
Outcome
No significant changeOvulation rate, Exp. 1
Study
pign: not reported in source
Cyclic gilts
Comparator
Vehicle or control injections
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
20 USP units (20 IU), once per day · intravenous · d 10, 12, 14 and 16 after estrusAs given in this study (pig).
Measurements
Corpora lutea, oxytocin
12.1 count
Exp. 1
Corpora lutea, control
12 count
Exp. 1
Source sentences
Summary
without affecting ovulation rate (12.1 vs. 12.0 +/- .7 corpora lutea; OT vs control gilts)
1 context sentence(design, population, supporting numbers)
Summary · context
Oxytocin (OT) stimulates pulsatile secretion of uterine PGF2 alpha in ruminants, but the role of OT in regulation of the estrous cycle of pigs is not clear. four experiments were performed to examine the effect of exogenous OT on interestrous interval of intact cyclic and hysterectomized gilts.
Report a problemFND-0865544402
03AnimalAnimal study (in vivo)Efficacy outcome
In cyclic gilts, twice-daily intravenous oxytocin infusions did not change the interestrous interval (20.6 d versus 20.4 d in controls).
In plain wordsIn female pigs, oxytocin infused into a vein twice a day did not change the time between heats compared with controls.
Peptide
Oxytocin
Outcome
No significant changeInterestrous interval, Exp. 2 (i.v. infusions twice per day)
Study
pign: not reported in source
Cyclic gilts
Comparator
Control gilts
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
20 USP units, twice per day · intravenous · d 10 to 16 after estrusAs given in this study (pig).
Measurements
Interestrous interval, oxytocin
20.6 d
Exp. 2
Interestrous interval, control
20.4 d
Exp. 2
Source sentences
Summary
i.v. infusions of 20 USP units of OT, twice/day via an indwelling jugular catheter on d 10 to 16 after estrus, did not alter interestrous interval (20.6 +/- .3 d) compared with control gilts (20.4 +/- .3 d).
1 context sentence(design, population, supporting numbers)
Summary · context
Oxytocin (OT) stimulates pulsatile secretion of uterine PGF2 alpha in ruminants, but the role of OT in regulation of the estrous cycle of pigs is not clear. four experiments were performed to examine the effect of exogenous OT on interestrous interval of intact cyclic and hysterectomized gilts.
Report a problemFND-0865544403
04AnimalAnimal study (in vivo)Efficacy outcome
In cyclic gilts, jugular plasma progesterone on d 9 to 21 after estrus did not differ between oxytocin and control groups.
In plain wordsIn female pigs, blood progesterone did not differ between oxytocin-treated pigs and controls.
Peptide
Oxytocin
Outcome
No significant changePlasma progesterone, Exp. 2
Study
pign: not reported in source
Cyclic gilts
Comparator
Control gilts
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
20 USP units, twice per day · intravenous · d 10 to 16 after estrusAs given in this study (pig).
Source sentences
Summary
Concentrations of progesterone in jugular vein plasma did not differ between treatment groups on d 9 to 21 after estrus.
1 context sentence(design, population, supporting numbers)
Summary · context
Oxytocin (OT) stimulates pulsatile secretion of uterine PGF2 alpha in ruminants, but the role of OT in regulation of the estrous cycle of pigs is not clear. four experiments were performed to examine the effect of exogenous OT on interestrous interval of intact cyclic and hysterectomized gilts.
Report a problemFND-0865544404
05AnimalAnimal study (in vivo)Efficacy outcome
In cyclic gilts, twice-daily intramuscular oxytocin shortened the interestrous interval to 20.6 d versus 22.3 d in controls.
In plain wordsIn female pigs, oxytocin injected into muscle twice a day shortened the time between heats compared with controls.
Peptide
Oxytocin
Outcome
DecreaseInterestrous interval, Exp. 3 (i.m. injections twice per day)
Study
pign: not reported in source
Cyclic gilts
Comparator
Control gilts
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
20 USP units, twice per day · intramuscular · d 10 to 16 after estrusAs given in this study (pig).
Measurements
Interestrous interval, oxytocin
20.6 d
Exp. 3
Interestrous interval, control
22.3 d
Exp. 3
Source sentences
Summary
i.m. injections of 20 USP units of OT, twice/day on d 10 to 16 after estrus, decreased (P < .05) interestrous interval (20.6 +/- .4 d) compared with control gilts (22.3 +/- .4 d).
1 context sentence(design, population, supporting numbers)
Summary · context
Oxytocin (OT) stimulates pulsatile secretion of uterine PGF2 alpha in ruminants, but the role of OT in regulation of the estrous cycle of pigs is not clear. four experiments were performed to examine the effect of exogenous OT on interestrous interval of intact cyclic and hysterectomized gilts.
Report a problemFND-0865544405
06AnimalAnimal study (in vivo)Efficacy outcome
In uterine-intact gilts, twice-daily intramuscular oxytocin shortened the interestrous interval to 20.7 d versus 21.8 d with control injections.
In plain wordsIn female pigs with a uterus, oxytocin injected into muscle twice a day shortened the time between heats compared with control injections.
Peptide
Oxytocin
Outcome
DecreaseInterestrous interval, Exp. 4 (i.m. injections, uterine-intact gilts)
Study
pign: not reported in source
Cyclic gilts
Comparator
Control injections
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
20 USP units, twice per day · intramuscular · d 10 to 16 after estrusAs given in this study (pig).
Measurements
Interestrous interval, oxytocin
20.7 d
Exp. 4
Interestrous interval, control
21.8 d
Exp. 4
Source sentences
Summary
i.m. injections of 20 USP units of OT, twice/day on d 10 to 16 after estrus, decreased (P < .05) interestrous interval (20.7 +/- .3 d) compared with control injections in uterine-intact gilts (21.8 +/- .3 d).
1 context sentence(design, population, supporting numbers)
Summary · context
Oxytocin (OT) stimulates pulsatile secretion of uterine PGF2 alpha in ruminants, but the role of OT in regulation of the estrous cycle of pigs is not clear. four experiments were performed to examine the effect of exogenous OT on interestrous interval of intact cyclic and hysterectomized gilts.
Report a problemFND-0865544406
07AnimalAnimal study (in vivo)Efficacy outcome
In hysterectomized gilts, no animal returned to estrus by d 28 with either oxytocin or control injections.
In plain wordsIn female pigs without a uterus, no pig returned to heat, whether given oxytocin or control injections.
Peptide
Oxytocin
Outcome
No significant changeReturn to estrus in hysterectomized gilts
Study
pign: not reported in source
Cyclic gilts
Comparator
Control injections
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · d 10 to 16 after estrusAs given in this study (pig).
Source sentences
Summary
None of the gilts hysterectomized on d 7 and treated on d 10 to 16 after estrus with either OT or control injections returned to estrus by d 28, and all had increased plasma progesterone on d 21 to 27.
1 context sentence(design, population, supporting numbers)
Summary · context
Oxytocin (OT) stimulates pulsatile secretion of uterine PGF2 alpha in ruminants, but the role of OT in regulation of the estrous cycle of pigs is not clear. four experiments were performed to examine the effect of exogenous OT on interestrous interval of intact cyclic and hysterectomized gilts.
Report a problemFND-0865544407
08AnimalAnimal study (in vivo)Efficacy outcome
In hysterectomized gilts, the mean weight of individual corpora lutea did not differ between oxytocin and control groups (502 versus 449 mg).
In plain wordsIn female pigs without a uterus, oxytocin did not change the weight of the corpora lutea compared with controls.
Peptide
Oxytocin
Outcome
No significant changeWeight of individual corpora lutea in hysterectomized gilts
Study
pign: not reported in source
Cyclic gilts
Comparator
Control gilts
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · d 10 to 16 after estrusAs given in this study (pig).
Measurements
Mean individual corpus luteum weight, oxytocin
502 mg
hysterectomized
Mean individual corpus luteum weight, control
449 mg
hysterectomized
Source sentences
Summary
Mean weight of individual corpora lutea (502 vs 449 +/- 28 mg
1 context sentence(design, population, supporting numbers)
Summary · context
Oxytocin (OT) stimulates pulsatile secretion of uterine PGF2 alpha in ruminants, but the role of OT in regulation of the estrous cycle of pigs is not clear. four experiments were performed to examine the effect of exogenous OT on interestrous interval of intact cyclic and hysterectomized gilts.
Report a problemFND-0865544408
09AnimalAnimal study (in vivo)Efficacy outcome
In hysterectomized gilts, the total weight of corpora lutea did not differ between oxytocin and control groups (5,758 versus 5,126 mg).
In plain wordsIn female pigs without a uterus, oxytocin did not change the total weight of the corpora lutea compared with controls.
Peptide
Oxytocin
Outcome
No significant changeTotal weight of corpora lutea in hysterectomized gilts
Study
pign: not reported in source
Cyclic gilts
Comparator
Control gilts
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · d 10 to 16 after estrusAs given in this study (pig).
Measurements
Total corpora lutea weight, oxytocin
5758 mg
hysterectomized
Total corpora lutea weight, control
5126 mg
hysterectomized
Source sentences
Summary
total weight of corpora lutea (5,758 vs. 5,126 +/- 298 mg
1 context sentence(design, population, supporting numbers)
Summary · context
Oxytocin (OT) stimulates pulsatile secretion of uterine PGF2 alpha in ruminants, but the role of OT in regulation of the estrous cycle of pigs is not clear. four experiments were performed to examine the effect of exogenous OT on interestrous interval of intact cyclic and hysterectomized gilts.
Report a problemFND-0865544409

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PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:53 UTC
First added · source update from Europe PMC

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