Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptides (PACAP27) and PACAP38) protect CD4+CD8+ thymocytes from glucocorticoid-induced apoptosis.

Delgado M, Garrido E, Martinez C, Leceta J, Gomariz RP

Blood1 Jun 1996Cited by 39 (Europe PMC)

PMID8652828DOI10.1182/blood.v87.12.5152.bloodjournal87125152PepBankPUB-08652828

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Activity measurement
In rat thymocytes in vitro, VIP significantly inhibited the DNA fragmentation that is characteristic of glucocorticoid-induced apoptosis.
In plain wordsIn cells, VIP reduced a sign of steroid-induced cell death in rat thymus cells.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseDexamethasone-induced DNA fragmentation
Study
ratn: not reported in source
thymocytes in vitro
Outcome group
Immune response · Immune and inflammation
Studied dose
10(-13) to 10(-6) mol/LAs given in this study (rat).
Source sentences
Summary
The results show that VIP and both PACAPs inhibit significantly and in a similar way the DNA fragmentation characteristic of glucocorticoid-induced apoptosis and increase the cell survival of thymocytes, with a maximal effect observed at 10(-8) to 10(-9) mol/L.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, the effects of vasoactive intestinal peptide (VIP) and the pituitary adenylate cyclase-activating polypeptides, PACAP27 and PACAP38, in a concentration range from 10(-13) to 10(-6) mol/L were studied in vitro on the spontaneous and dexamethasone (DEX)-induced apoptosis in rat thymocytes.
Report a problemFND-0865282801
02LabIn vitro (cells)Activity measurement
In rat thymocytes in vitro, VIP increased the survival of thymocytes exposed to dexamethasone.
In plain wordsIn cells, VIP increased the survival of rat thymus cells exposed to a steroid.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseThymocyte survival
Study
ratn: not reported in source
thymocytes in vitro
Outcome group
Immune response · Immune and inflammation
Studied dose
10(-13) to 10(-6) mol/LAs given in this study (rat).
Source sentences
Summary
The results show that VIP and both PACAPs inhibit significantly and in a similar way the DNA fragmentation characteristic of glucocorticoid-induced apoptosis and increase the cell survival of thymocytes, with a maximal effect observed at 10(-8) to 10(-9) mol/L.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, the effects of vasoactive intestinal peptide (VIP) and the pituitary adenylate cyclase-activating polypeptides, PACAP27 and PACAP38, in a concentration range from 10(-13) to 10(-6) mol/L were studied in vitro on the spontaneous and dexamethasone (DEX)-induced apoptosis in rat thymocytes.
Report a problemFND-0865282802
03LabIn vitro (cells)Mechanism
In rat thymocytes, a VIP-receptor antagonist partly reversed the inhibition of dexamethasone-induced apoptosis by VIP, which points to a VIP1-receptor mediated response.
In plain wordsIn cells, a VIP-receptor blocker partly undid the protective effect of VIP, which suggests that VIP acts through its own receptor.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableReversal of VIP effect by VIP-receptor antagonist
Study
ratn: not reported in source
thymocytes in vitro
Outcome group
Immune response · Immune and inflammation
Studied dose
10(-13) to 10(-6) mol/LAs given in this study (rat).
Source sentences
Summary
This study showed the ability of the VIP-receptor (VIP-R) antagonist [N-Ac-Tyr1,D-Phe2]-GRF(1-29) amide to partially reverse the inhibitory effect of VIP and both PACAPs on DEX-induced apoptosis, providing evidence for a specific VIP1-R-mediated response and supporting the involvement of a single re…
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, the effects of vasoactive intestinal peptide (VIP) and the pituitary adenylate cyclase-activating polypeptides, PACAP27 and PACAP38, in a concentration range from 10(-13) to 10(-6) mol/L were studied in vitro on the spontaneous and dexamethasone (DEX)-induced apoptosis in rat thymocytes.
Report a problemFND-0865282803
04LabIn vitro (cells)Activity measurement
In rat thymocytes, VIP protected mainly CD4+CD8+ thymocytes from glucocorticoid-induced apoptosis.
In plain wordsIn cells, VIP mainly protected one type of rat thymus cell from steroid-induced cell death.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseProtection of CD4+CD8+ thymocytes from apoptosis
Study
ratn: not reported in source
thymocytes in vitro
Outcome group
Immune response · Immune and inflammation
Studied dose
10(-13) to 10(-6) mol/LAs given in this study (rat).
Source sentences
Summary
Phenotypic analysis showed that VIP, PACAP27, and PACAP38 protect predominantly CD4+CD8+ thymocytes from glucocorticoid-induced apoptosis.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present study, the effects of vasoactive intestinal peptide (VIP) and the pituitary adenylate cyclase-activating polypeptides, PACAP27 and PACAP38, in a concentration range from 10(-13) to 10(-6) mol/L were studied in vitro on the spontaneous and dexamethasone (DEX)-induced apoptosis in rat thymocytes.
Report a problemFND-0865282804

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

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