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Study · Animal study (in vivo) · mouse and rat · 1996

2 results

Oxytocin and oxytocin-analogue F314 inhibit cell proliferation and tumor growth of rat and mouse mammary carcinomas.

Cassoni P, Sapino A, Papotti M, Bussolati G

International journal of cancer1 Jun 1996Cited by 42 (Europe PMC)

PMID8647655 (opens in a new tab)DOI10.1002/(sici)1097-0215(19960611)66:6<817::aid-ijc18>3.0.co;2-# (opens in a new tab)PepBankPUB-08647655
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In animals with mouse mammary, mouse colon or rat mammary carcinoma xenografts, oxytocin and the analog F314 each inhibited tumor growth.

    In plain wordsIn mice and rats with transplanted tumors, oxytocin and a related analog slowed tumor growth.

    Peptide
    Oxytocin
    Outcome
    DecreaseTumor growth of xenografts
    Study

    mouse and ratn: not reported in source

    xenografts of TS/A, C26 and D-R3230AC tumors
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both cell proliferation and tumor growth were inhibited by OT and F314.
    2 context sentences
    Summary · context
    In all cases, proliferation was previously assessed by cell counting in cultured cell lines, whereas tumor growth was checked by serial measures of tumor volume and by evaluation of tumor weight at the end of the experiment.
    Summary · context
    The effects of oxytocin (OT) and the OT-analogue F314 were investigated an xenografts of mouse mammary and colon carcinomas (TS/A and C26 tumors) and of rat mammary carcinoma (D-R3230AC).
  2. 02LabIn vitro (cells)Efficacy outcome

    In cultured mouse and rat carcinoma cell lines, oxytocin and the analog F314 each inhibited cell proliferation.

    In plain wordsIn lab-grown mouse and rat tumor cells, oxytocin and a related analog slowed cell growth.

    Peptide
    Oxytocin
    Outcome
    DecreaseCell proliferation of mammary and colon carcinoma cell lines
    Study

    mouse and ratn: not reported in source

    cultured cell lines of TS/A, C26 and D-R3230AC tumors
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both cell proliferation and tumor growth were inhibited by OT and F314.
    2 context sentences
    Summary · context
    In all cases, proliferation was previously assessed by cell counting in cultured cell lines, whereas tumor growth was checked by serial measures of tumor volume and by evaluation of tumor weight at the end of the experiment.
    Summary · context
    The effects of oxytocin (OT) and the OT-analogue F314 were investigated an xenografts of mouse mammary and colon carcinomas (TS/A and C26 tumors) and of rat mammary carcinoma (D-R3230AC).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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